Fmoc-Leu-OH CAS 35661-60-0 N-Fmoc-L-Leucine Purity > 99.0% (HPLC) Hoobkas
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom ntawm N-Fmoc-L-Leucine (Fmoc-Leu-OH) (CAS: 35661-60-0) nrog cov khoom zoo.Ruifu Chemical muab ntau cov amino acids.Peb tuaj yeem muab cov khoom xa tuaj thoob ntiaj teb, tus nqi sib tw, me me thiab ntau ntau muaj.Muas Fmoc-Leu-OH,Please e-mail: alvin@ruifuchem.com
| Tshuaj npe | N-Fmoc-L-Leucine |
| Synonyms | Fmoc-Leu-OH;Fmoc-L-Leu-OH;Fmoc-L-Leucine;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-Leucine;N-(9-Fluorenylmethoxycarbonyl)-L-Leucine |
| Tshuag xwm txheej | Hauv Tshuag, Muaj Peev Xwm Ntau Lawm rau Tons ib hlis |
| CAS Nr | 35661-60-0 |
| Molecular Formula | C21H23NO4 |
| Molecular Luj | 353.42 g / mol |
| Melting Point | 153.0 txog 160.0 ℃ |
| Qhov ntom | 1.207 ± 0.06 g / cm3 |
| rhiab heev | Hygroscopic |
| Solubility hauv Methanol | Yuav luag Transparency |
| Cia Temp. | Qhov chaw txias & qhuav (2 ~ 8 ℃) |
| COA & MSDS | Muaj |
| Qeb | Fmoc-Amino Acids |
| Hom | Ruifu Tshuaj |
| Cov khoom | Kev soj ntsuam Standards | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb hmoov | Dawb hmoov |
| Kev sib hloov tshwj xeeb [α]20/D | -25.0 ° ± 2.0 ° (C = 1 hauv DMF) | -24.6 ° |
| Melting Point | 153.0 txog 160.0 ℃ | 155.1 ℃ |
| TLC | ≥98.0% | > 98.0% |
| Optical Purity | <0.30% D-Enantiomer | Ua raws |
| Clarity of Solution | 0.3 gram hauv 2ml DMF Clear Solution | Ua raws |
| Kaiser Test | <0.05% | <0.05% |
| Dej los ntawm Karl Fischer | <0.50% | 0.12% |
| Poob rau ziab | ≤0.50% (60 ℃, 2h) | 0.15% |
| Fmoc-β-Ala-OH | <0.20% (HPLC) | Ua raws |
| Fmoc-β-Ala-Leu-OH | <0.10% (HPLC) | Ua raws |
| Fmoc-Leu-Leu-OH | <0.10% (HPLC) | Ua raws |
| Fmoc-Ile-OH | <0.10% (HPLC) | Ua raws |
| Assay Dawb Amino Acid | <0.20% (GC) | Ua raws |
| Ethyl Acetate | <0.50% (GC) | Ua raws |
| Purity / Analysis Method | > 99.0% (HPLC) | 99.85% |
| Loj Spectrum | Nyob rau hauv raws li tus qauv | Ua raws |
| NMR Spectrum | Nyob rau hauv raws li tus qauv | Ua raws |
| Xaus | Cov khoom tau raug kuaj & ua raws li cov specifications | |
Pob: Fluorinated Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, lossis raws li cov neeg siv khoom xav tau.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov txias thiab qhuav (2 ~ 8 ℃) warehouse kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Cov txheej txheem tshuaj xyuas
1. Kev tshwm sim
--Kev kuaj pom
2. Purity (HPLC)
2.1 Kev ntsuas
Kev ua haujlwm siab ua kua chromatography, PDA ntes.
Electronic analytical tshuav nyiaj li cas
2.2 Reagents
Acetonitrile (chromatographic qib), Trifluoroacetic acid (chromatographic qib)
2.3 Chromatographic tej yam kev mob
2.3.1 Kem: YMC-ODS-AM, 5μL, 250x4.6 mm
2.3.2 Kev Ntsuas wavelength: INC220nm
Tus nqi ntws: 1.0mL / min
Qauv loj: 10μL (reference)
Diluent: acetonitrile
Lub sijhawm sau cov ntaub ntawv: 25.00 min
2.4 Mobile theem npaj
Txawb theem A (0.1% trifluoroacetic acid dej): kom raug nqus 2.0ml trifluoroacetic acid, diluted nrog dej rau 2000ml, sib tov zoo, thiab degassing;
Txawb theem B (0.1% acetonitrile trifluoroacetic acid): kom raug nqus 2.0ml trifluoroacetic acid, diluted rau 2000ml nrog acetonitrile, sib tov thiab degassing;
Lub sij hawm (min) A% B%
0.00 90 10
13.00 10 90 Nws
18.00 10 90 Nws
18.019010 Nws
23.00 Nws
2.6 Kev npaj cov qauv kev daws teeb meem
Ntsuas thiab yaj 0.1g qauv nrog acetonitrile thiab dilute rau 100ml, co zoo rau kev siv, los yog tib lub concentration.Npaj ob qho piv txwv ua ke.
2.7 Kev txiav txim siab
Txheeb xyuas tus qauv raws li cov txheej txheem hauv qab no:
Ntau tshaj 1 txhaj tshuaj dawb paug
1 koob qauv tshuaj 1 #
1 koob qauv tshuaj 2 #
2.8 Cov txiaj ntsig suav
2.8.1 Txoj kev peak area normalization yog siv los xam HPLC purity los ntawm kev txiav tawm qhov chaw seem.
2.8.2 Tus txheeb ze sib txawv ntawm qhov purity ntawm ob koob yuav tsum tsis txhob ntau tshaj 1%
2.8.3 Yog tias cov txiaj ntsig ntawm ob qho kev txhaj tshuaj ua tau raws li qhov kev lees paub, qhov nruab nrab purity raug coj los ua qhov kawg tshwm sim.
3, Melting point - RY-1 melting point ntsuas
4. Poob ntawm txoj kev ntsuas kom qhuav
4.1 Cov cuab yeej:
Hluav taws xob thermostatic ziab qhov cub, 1/10,000 tshuav nyiaj li cas.
4.2 Cov txheej txheem:
Hauv ib lub raj mis uas hnyav hnyav nrog qhov hnyav tas li thiab lub qhov ncauj qhuav dhau, hnyav 1 gram (qhov tseeb rau 0.0001 gram) ntawm cov qauv.Cov qauv yuav tsum sib npaug zos rau hauv qab ntawm lub raj mis hnyav nrog lub thickness tsis pub tshaj 10 hli, muab tso rau hauv ib lub thermostatic hluav taws xob ziab qhov cub, qhuav ntawm 105 ~ 110 ℃ rau 3 teev, thiab ces txav mus rau hauv chav tsev kom qhuav kom txias. chav ntsuas kub rau qhov hnyav.
Kev suav: Poob ntawm ziab % = (M1-M2) ÷M × 100
Qhov twg: M1: qhov hnyav ntawm cov qauv thiab ntsuas lub raj mis ua ntej ziab, grams
M2: qhov hnyav ntawm cov qauv thiab ntsuas lub raj mis tom qab ziab, hauv grams
M: Qauv hnyav, grams
5. Kev sib hloov tshwj xeeb
- Kev sib hloov tshwj xeeb yog ntsuas raws li GB / T613-1988
Kev npaj ua qauv: 0.5000g qauv raug ntsuas kom raug thiab txav mus rau lub raj mis huv thiab qhuav 50ml, 20ml DMF tau ntxiv, lub raj mis tau capped thiab shaken kom yaj, thiab tom qab ntawd diluted mus rau qhov ntsuas nrog DMF.
Kuaj: Kho qhov xoom ntawm lub gyroscope ua ntej qhov kev xeem, tom qab ntawd thauj cov raj kuaj nrog cov qauv kev daws teeb meem, sau lub kaum sab xis tig, thiab suav cov kev sib hloov ntawm cov qauv nrog cov qauv hauv qab no.
[a]D20 = (r × 50) ÷ (L × W)
[a]D20: Kev sib hloov kho qhov muag tshwj xeeb ntawm 25 ℃ ntawm cov qauv kev daws teeb meem
r: Kev sib hloov kho qhov muag pom ntawm 20 ℃ rau cov qauv kev daws teeb meem
50: Ntim ntawm cov qauv npaj tov (ml)
w: Qauv hnyav (g)
L: Optical rotation tube ntev (dm)
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
Hazard Symbols Xi - Irritant
Risk Codes 36/37/38 - Irritating rau qhov muag, ua pa thiab tawv nqaij.
Safety Description S22 - Tsis txhob ua pa plua plav.
S24/25 - Tsis txhob sib cuag nrog daim tawv nqaij thiab qhov muag.
S36/37/39 - Hnav cov khaub ncaws tiv thaiv, hnab looj tes thiab tiv thaiv qhov muag / ntsej muag.
S27 - Tshem tawm tag nrho cov khaub ncaws tsis huv tam sim ntawd.
S26 - Nyob rau hauv rooj plaub ntawm qhov muag, yaug tam sim ntawd nrog dej txaus thiab nrhiav kev kho mob.
WGK Germany 3
HS Code 2922491990
N-Fmoc-L-Leucine (Fmoc-Leu-OH) (CAS: 35661-60-0) yog ib qho amino acid derivative uas tuaj yeem npaj los ntawm cov tshuaj tiv thaiv ntawm L-Leucine thiab 9-Fluorenomethoxycarbonyl Chloride.
Fmoc-amino acids, siv nyob rau hauv peptide synthesis, siv los ua cov organic synthesis intermediate, tshuaj intermediate, biochemical reagent lossis tshuaj reagent.
Fmoc-L-Leu-OH, yog ib qho amino acid derivative, siv nyob rau hauv peptide chemistry.Txheem lub tsev thaiv rau niaj hnub khoom theem peptide synthesis tom qab Fmoc-tactics.Nws kuj yog ib qho ntawm cov tshiab PPARγ ligands uas tuaj yeem qhib PPARγ hauv ntau txoj kev, uas txo cov kev sib txawv ntawm osteoclasts, thiab yog li cov hom phiaj kho mob ntshav qab zib zoo dua li cov tshuaj tiv thaiv kab mob.
Kev npaj 1.05g (0.008 mol) L-Leucine cov khoom yog yaj hauv 10% sodium carbonate tov, stirred kom tag nrho yaj glycine khoom, thiab 9-fluorene methoxycarbonyl chloride (2.10g, 0.008 mol) tov yaj nyob rau hauv toluene (2 ~ 205 ml) yog ntxiv dropwise ntawm 20 ~ 30 ℃, tee ntxiv rau 30 ~ 60 feeb, xaus lub dropwise ntxiv, do ntawm 20 ~ 30 ℃ rau 1 ~ 8 teev, ntxiv 30-200 ml dej rau dilute, thiab extract nrog n-butyl acetate (80 ml) kom tshem tawm ntau tshaj 9-fluorene methoxycarbonyl chloride, The tau aqueous theem yog acidified nrog concentrated hydrochloric acid rau PH = 0.5 ~ 3.5, thiab ces muab rho tawm nrog n-butyl acetate (80 ml), thiab cov roj theem tau yog ntxuav nrog dej kom tshem tawm hydrochloric acid, cov roj theem yog concentrated kom tshem tawm n-butyl acetate hnyav, dawb crystals tau precipitated, lim thiab qhuav kom tau 2.46g ntawm Nα-9-fluorene methoxycarbonyl-L-leucine, nrog ib tug yield ntawm 87.0 %.
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