Fulvestrant (ICI 182780) CAS 129453-61-8 API Hoobkas High Quality Featured duab

Fulvestrant (ICI 182780) CAS 129453-61-8 API Hoobkas Zoo

Lus piav qhia luv luv:

Lub npe: Fulvestrant (ICI 182780)

CAS: 129453-61-8 Nr

Cov tsos mob: Dawb rau Off-White Crystalline Hmoov

Kev ntsuam xyuas: 97.0% ~ 102.0% (ntawm qhuav hauv paus)

Fulvestrant yog siv los kho cov tshuaj hormone-rhiab heev mob qog noj ntshav hauv cov poj niam postmenopausal.

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Product Detail

Yam khoom

Khoom cim npe

Nqe lus piav qhia:

Chaw tsim tshuaj paus Supply nrog High Purity thiab ruaj khov zoo
Lub npe: Fulvestrant
CAS: 129453-61-8 Nr
Fulvestrant yog siv los kho cov tshuaj hormone-rhiab heev mob qog noj ntshav hauv cov poj niam postmenopausal.
API High Quality, Commercial Production

Chemical Properties:

Tshuaj npe	Fulvestrant
Synonyms	(7α,17β)-7-[9-[(4,4,5,5,5-Pentafluorpentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-3,17-diol;TIAB SA 182780
CAS Nr	129453-61-8
CAT Number	Tus Qauv Zauv: RF-API81
Tshuag xwm txheej	Nyob rau hauv Tshuag, ntau lawm Scale nce mus txog pua pua ntawm Kilograms
Molecular Formula	C32H47F5O3S
Molecular Luj	606.77 ib
Melting Point	104.0 ~ 106.0 ℃
Solubility	Soluble hauv Methanol, Ethanol;Insoluble hauv dej
Hom	Ruifu Tshuaj

Specifications:

Yam khoom	Specifications
Qhov tshwm sim	Dawb rau Off-White Crystalline Hmoov
Kev txheeb xyuas	Los ntawm IR, HPLC
Specific Optical Rotation	+108.0 ° rau + 115.0 °
Poob rau ziab	≤0.50%
Residue ntawm Ignition	≤0.10%
6-Keto-Fulvestrant	≤0.10%
6,7-Tswv Ntuj	≤0.10%
Fulvestrant Sulfone	≤ 0.20%
Fulvestrant Extended	≤ 0.30%
Fulvestrant Sterol Dimmer	≤ 0.80%
Txhua tus neeg tsis paub meej impurity	≤0.10%
Tag nrho cov impurities	≤ 1.0%
Fulvestrant A	42.0% ~ 48.0%.
Fulvestrant B	52.0% ~ 58.0%.
DMF	≤620ppm
Hnyav Hlau	≤10ppm
Assay	97.0% ~ 102.0% (ntawm qhuav hauv paus)
Cia	Khaws cia rau hauv lub thawv kaw zoo uas tiv thaiv lub teeb kom txias ntawm 2 ~ 8 ℃
Test Standard	Teb Chaws Asmeskas Pharmacopoeia (USP) Standard
Kev siv	Estrogen Receptor Antagonist

Pob & Cia:

Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.

Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.

Qhov zoo:

FAQ:

Daim ntawv thov:

Fulvestrant (ICI-182780) CAS 129453-61-8, yog ib qho tshuaj txhaj rau cov leeg nqaij tsim los ntawm lub tuam txhab AstraZeneca thiab yog siv los kho cov tshuaj hormone-rhiab heev ntawm lub mis mob cancer hauv cov poj niam postmenopausal.Fulvestrant yog tib cov tshuaj antiestrogen uas tuaj yeem siv dav hauv kev kho mob tom qab kev kho tamoxifen tsis ua tiav.Cov tshuaj no yog ib hom kev kho mob endocrine, yog li nws yuav tsis ua rau muaj kev cuam tshuam tsis zoo uas feem ntau pom hauv cov kws khomob, muab kev ua raws li tus neeg mob zoo.Ntau qhov kev sim tshuaj tau pom tias 250mg Fulvestrant yog qhov ua tau zoo thiab muaj kev nyab xeeb tsis tu ncua raws li kab thib ob ntawm kev kho mob qog noj ntshav siab.Fulvestrant yog ib qho hluavtaws Estrogen Receptor (ER) antagonist nrog IC50 ntawm 0.94 nM hauv kev kuaj tsis muaj xov tooj ntawm tes.Fulvestrant kuj induces autophagy thiab apoptosis thiab muaj antitumor kev ua.