Gefitinib CAS 184475-35-2 Purity > 99.5% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom ntawm Gefitinib (CAS: 184475-35-2) nrog cov khoom zoo.Ruifu Chemical tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, kev pabcuam zoo heev, me me thiab ntau ntau muaj.Yuav Gefitinib thiab intermediates,Please contact: alvin@ruifuchem.com
| Tshuaj npe | Gefitinib |
| Synonyms | Gefitinib Dawb Base;Iressa;ZD1839;ZD-1839;N-(3-Chloro-4-Fluorophenyl)-7-Methoxy-6-(3-Morpholinopropoxy)quinazolin-4-Amine;N-(3-Chloro-4-Fluorophenyl)-7-Methoxy-6-[3-(4-Morpholinyl)propoxy]-4-Quinazolinamine |
| Tshuag xwm txheej | Hauv Tshuag, Kev Lag Luam Ntau Lawm |
| CAS Nr | 184475-35-2 |
| Molecular Formula | C22H24ClFN4O3 |
| Molecular Luj | 446,91 g / mol |
| Melting Point | 194.0 txog 198.0 ℃ |
| Qhov ntom | 1.322 ± 0.06 g / cm3 |
| Dej Solubility | Insoluble hauv dej |
| Solubility | Soluble hauv DMSO |
| Cia Temp. | Chav ntsuas kub |
| Kev xa khoom | Ambient |
| COA & MSDS | Muaj |
| Keeb kwm | Shanghai, Suav |
| Hom | Ruifu Tshuaj |
| Cov khoom | Kev soj ntsuam Standards | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb rau Off-White Powder | Ua raws |
| Poob rau ziab | <0.50% | 0.13% |
| Residue ntawm Ignition | <0.20% | 0.06% |
| Ib leeg Impurity | <0.10% | 0.09% |
| Tag nrho cov impurities | <0.50% | 0.20% |
| Heavy Metals (Pb) | ≤10ppm | <10ppm |
| Purity / Analysis Method | > 99.5% (HPLC) | 99.80% |
| Infrared Spectrum | Raws li tus qauv | Ua raws |
| 1 H NMR Spectrum | Raws li tus qauv | Ua raws |
| Xaus | Cov khoom tau raug kuaj thiab ua raws li cov lus qhia tshwj xeeb | |
Pob:Fluorinated Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, lossis raws li cov neeg siv khoom xav tau.
Cia txias:Khaws lub thawv kaw kom nruj thiab khaws cia rau hauv qhov chaw txias, qhuav thiab zoo-ventilated warehouse kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.
Tsis siv rau tib neeg.Tsis siv rau hauv kev kuaj mob lossis kev kho mob.Rau kev tshawb fawb hauv vitro tsuas yog siv xwb.
Tsis muaj ib qho ntawm cov khoom yuav raug xa mus rau cov teb chaws uas qhov no tuaj yeem cuam tshuam nrog cov patents uas twb muaj lawm.Txawm li cas los xij lub luag haujlwm kawg yog nyob nrog Tus Neeg Yuav Khoom.
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
| Kev nyab xeeb piav qhia | 24/25 - Tsis txhob sib cuag nrog daim tawv nqaij thiab qhov muag. |
| HS Code | 29 349 999 ib |
Gefitinib (CAS: 184475-35-2) yog ib qho tshuaj tiv thaiv qog noj ntshav uas tsim los ntawm AstraZeneca, UK.Nws yog thawj cov tshuaj tiv thaiv molecular rau kev kho mob ntawm cov qog nqaij hlav tsis me me.Nws ua hauj lwm los ntawm kev xaiv inhibiting lub teeb liab transduction txoj kev ntawm epidermal loj hlob yam receptor tyrosine kinase (EGFR-TK).Epidermal growth factor (EGF) yog polypeptide nrog cov txheeb ze molecular loj ntawm 6.45 × 103, uas tuaj yeem ua ke nrog epidermal growth factor receptor (EGFR) ntawm lub hom phiaj cell membrane los tsim cov teebmeem lom.EGFR yog tyrosine kinase (TK) hom receptor.Thaum nws khi rau EGF, nws tuaj yeem txhawb nqa TK kev ua haujlwm hauv lub cev tau txais, uas ua rau autophosphorylation ntawm receptor tyrosine residues, muab kev faib tawm tsis tu ncua rau cov hlwb, ua rau cov cell proliferation thiab sib txawv.EGFR muaj ntau nyob rau hauv tib neeg cov ntaub so ntswg thiab yog heev qhia nyob rau hauv malignant qog.Los ntawm kev thaiv cov EGFR teeb liab txoj hauv kev ntawm lub xov tooj ntawm tes, gefitinib cuam tshuam cov qog loj hlob, metastasis thiab angiogenesis, thiab tuaj yeem ua rau apoptosis ntawm cov qog hlwb.Thaum Lub Yim Hli 2002, gefitinib tau ua lag luam thawj zaug hauv Nyij Pooj ua thawj kab kev kho mob rau cov qog nqaij hlav tsis me me hauv qab lub npe lag luam Iressa.Nyob rau lub Tsib Hlis 2003, US Food and Drug Administration tau pom zoo gefitinib ua tus thib peb-kab monotherapy rau cov neeg mob uas tsis yog-me me ntawm lub ntsws cancer uas tsis muaj txiaj ntsig nrog platinum-based anticancer tshuaj thiab docetaxel chemotherapy.Tam sim no, nws tau txais kev pom zoo los ntawm Australia, Nyiv, Argentina, Singapore thiab Kaus Lim Qab Teb rau kev kho mob qog noj ntshav uas tsis yog me me hauv lub ntsws.Thaum Lub Ob Hlis 28, 2005, Tuam Tshoj Food and Drug Administration tau pom zoo gefitinib rau kev kho mob hauv zos qib siab lossis metastatic non-small cell lung cancer (NSCLC) uas yav tas los tau txais kev kho mob.Tam sim no nws tsis tau pom zoo siv los ua thawj kab kev kho mob rau NSCLC siab heev.Thaum Lub Xya Hli 1, 2009, European Medicines Agency tau tso cai gefitinib rau thawj-kab, thib ob-kab thiab thib peb-kab kev kho mob ntawm cov neeg laus hauv zos lossis cov kab mob metastatic uas tsis yog mob qog noj ntshav me me nrog EGFR noob hloov hauv cov neeg laus.
