Gemcitabine CAS 95058-81-4 Kev Ntsuas 98.0 ~ 102.0%
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom ntawm Gemcitabine (CAS: 95058-81-4) nrog cov khoom zoo.Ruifu Chemical tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, kev pabcuam zoo heev, me me thiab ntau ntau muaj.Yuav Gemcitabine,Please contact: alvin@ruifuchem.com
| Tshuaj npe | Gemcitabine |
| Synonyms | 2'-Deoxy-2',2'-Difluorocytidine;4-Amino-1-[3,3-Difluoro-4-Hydroxy-5-(Hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;dFDC;Gemzar (Lilly);LY-188011;dFdCyd;DDFC;2',2'-Difluoro-2'-deoxycytidine;2',2'-Difluorodeoxycytidine;Folfugem;GemLip;Gemcel;Gamcitabine |
| Tshuag xwm txheej | Hauv Tshuag, Muaj Peev Xwm Ntau Lawm 5 Tons |
| CAS Nr | 95058-81-4 |
| Related CAS | 122111-03-9 |
| Molecular Formula | C9H11F2N3O4 |
| Molecular Luj | 263.20 g / mol |
| Melting Point | 217.0 txog 222.0 ℃ |
| Qhov ntom | 1.84 ± 0.10g / cm3 |
| rhiab heev | Thaum tshav kub kub Sensitive |
| Dej Solubility | Xyaum Insoluble hauv dej |
| COA & MSDS | Muaj |
| Keeb kwm | Shanghai, Suav |
| Hom | Ruifu Tshuaj |
| Cov khoom | Specifications | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb los yog Yuav luag Dawb Crystalline Hmoov, Tsis muaj ntxhiab tsw | Ua raws |
| Cytosine | ≤0.10% | 0.002% |
| α-Isomer | ≤0.10% | 0.01% |
| Tus kheej impurity | ≤0.10% | 0.03% |
| Tag nrho cov impurities | ≤ 1.00% | 0.10% |
| Dej los ntawm Karl Fischer | ≤ 1.00% | 0.67% |
| Kev sib hloov tshwj xeeb | +68.0° ~ + 74.0° | +70.5 ° |
| Hnyav Hlau | ≤10ppm | <10ppm |
| Residue ntawm Ignition | ≤0.10% | 0.03% |
| Assay (los ntawm HPLC) | 98.0% ~ 102.0%. | 99.9% |
| Infrared Spectrum | Raws li tus qauv | Ua raws |
| 1 H NMR Spectrum | Raws li tus qauv | Ua raws |
| Xaus | Cov khoom tau raug kuaj thiab ua raws li cov lus qhia tshwj xeeb | |
Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws lub thawv kaw kom nruj thiab khaws cia rau hauv qhov chaw txias, qhuav thiab zoo-ventilated warehouse kom deb ntawm cov khoom tsis sib xws.Tsis txhob raug tshav ntuj ncaj qha, noo noo thiab kub heev.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
Risk Codes R21 - Ua phem rau ntawm daim tawv nqaij
R36/38 - Kab mob rau qhov muag thiab tawv nqaij.
R46 - Tej zaum yuav ua rau muaj kev puas tsuaj ntawm caj ces
R62 - Muaj peev xwm muaj feem cuam tshuam ntawm fertility
R63 - Muaj peev xwm tsim kev puas tsuaj rau tus menyuam hauv plab
Kev Nyab Xeeb Kev Nyab Xeeb S25 - Tsis txhob sib cuag nrog lub qhov muag.
S26 - Nyob rau hauv rooj plaub ntawm qhov muag, yaug tam sim ntawd nrog dej txaus thiab nrhiav kev kho mob.
S36/37 - Hnav cov khaub ncaws tiv thaiv thiab hnab looj tes tsim nyog.
S53 - Tsis txhob raug - tau txais cov lus qhia tshwj xeeb ua ntej siv.
HS Code 2934999091
Toxicity LD10 iv hauv nas: 200 mg/m2 (Abbruzzese)
Gemcitabine (CAS: 95058-81-4) yog ib qho tshuaj khomob uas siv los kho ntau hom mob qog noj ntshav.Qhov no suav nrog mob qog noj ntshav mis, mob qog noj ntshav tsis me me, mob qog noj ntshav pancreatic, mob qog noj ntshav zais zis, thiab mob qog noj ntshav biliary.Gemcitabine tau raug tshuaj xyuas rau kev siv hauv kev mob qog noj ntshav, thiab yog siv los sim hauv lymphomas thiab ntau yam qog nqaij hlav.Gemcitabine yog tswj hwm los ntawm txoj hlab ntshav, txij li nws feem ntau metabolized los ntawm txoj hnyuv.
Gemcitabine yog ib qho nucleotide analogue, uas belongs rau cov chav kawm ntawm kev tiv thaiv metabolic ntawm cov tshuaj tiv thaiv kab mob.Nws feem ntau ua rau DNA synthesis theem, uas yog, theem S.Raws li qee qhov xwm txheej, nws tuaj yeem tiv thaiv G1 theem ntawm kev nce mus rau theem S.Nws muaj cov yam ntxwv ntawm dav anticancer spectrum, tshwj xeeb mechanism ntawm kev txiav txim, tsis tshua muaj toxicity, tsis muaj cross-resistance rau lwm yam tshuaj kho mob thiab tsis muaj superposition ntawm toxicity.Chemicalbook, gemcitabine, tam sim no tau pom zoo siv nyob rau hauv ntau dua 90 lub teb chaws, ua nws thawj kab kev kho mob rau cov qog nqaij hlav qog nqaij hlav tsis me me thiab "tus qauv kub" rau kev mob qog noj ntshav pancreatic.
Xyoo 1999, CFDA tau pom zoo gemcitabine rau kev kho mob hauv zos qib siab lossis metastatic NSCLC, mob qog noj ntshav hauv zos lossis metastatic pancreatic cancer;Xyoo 2010, CChemicalbookFDA tau pom zoo gemcitabine ua ke nrog paclitaxel rau kev kho mob ntawm unresectable, lub zos recurrent los yog metastatic mis mob cancer uas tau rov tshwm sim tom qab adjuvant / neoadjuvant chemotherapy.
Gemcitabine yog ib qho dav-spectrum antimetabolite thiab deoxycytidine analogue nrog kev ua haujlwm antineoplastic.Raws li kev tswj hwm, gemcitabine hloov mus rau hauv cov metabolites nquag difluorodeoxycytidine diphosphate (dFdCDP) thiab difluorodeoxycytidine triphosphate (dFdCTP) los ntawm deoxycytidine kinase.dFdCTP sib tw nrog deoxycytidine triphosphate (dCTP) thiab muab tso rau hauv DNA.Qhov no xauv DNA polymerase yog li ua rau lub ntsej muag kaw thaum lub sij hawm DNA replication.Ntawm qhov tod tes, dFdCDP inhibits ribonucleotide reductase, yog li txo lub pas dej deoxynucleotide muaj rau DNA synthesis.Qhov txo qis hauv cov concentration ntawm intracellular ntawm dCTP potentiates kev koom ua ke ntawm dFdCTP rau hauv DNA.
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