H-Gly-Ome · HCl CAS 5680-79-5 Glycine Methyl Ester Hydrochloride Assay > 99.0%

1. Khoom: Cov khoom no yuav tsum yog cov hmoov dawb crystalline hmoov.
2. Assay:
1) Kev txiav txim siab ntawm Glycine Methyl Ester Hydrochloride kev soj ntsuam
1.1 Txoj kev
Nyob rau hauv acidic tej yam kev mob, tus qauv reacts nrog ib tug npaum li cas ntawm cov nyiaj nitrate, thiab cov nyiaj nitrate tshaj yog revertitrated nrog ammonium thiocyanate, xa mus rau ammonium ferric sulfate.
Raws li qhov taw qhia, tag nrho cov ntsiab lus chlorine tau txiav txim siab raws li qhov ntim ntawm cov qauv kev daws teeb meem, thiab tag nrho cov ntsiab lus chlorine raug rho tawm los ntawm cov ntsiab lus ntawm glycine hydrochloride kom tau txais Glycine Methyl Ester Hydrochloride cov ntsiab lus.
1.2 Reagents
Dibutyl phthalate;
Nitric acid daws: 2 + 3;
Silver nitrate txheem titration tov: c(AgNO3) = 0.1 mol/L
Ammonium thiocyanate txheem titration tov: c(NH4SCN) = 0.1 mol/L
Ammonium ferric sulfate (III) qhia kua: 80 g / L
1.3 Cov txheej txheem tsom xam
Qhov hnyav txog 0.5g qauv, raug rau 0.0001g.Muab tso rau hauv 250ml conical flask, yaj hauv 40ml dej, ntxiv 10 ml nitric acid tov, Ntxiv (50 ± 0.02) mL silver nitrate standard titration tov, 3mL ammonium ferric sulfate qhia tshuaj, 4mL dibutyl phthalate, thiab thiocyanate Ammonium standard titration tov yog titrated kom txog thaum cov tshuaj yog lub teeb xim av thiab tseem tsis muaj xim rau 30 s.
1.4 Cov txiaj ntsig suav
Qhov loj feem ntawm glycine methyl ester hydrochloric acid cov ntsiab lus w1, uas yog qhia raws li %, yog xam raws li Equation (1):
w1 = (c1V1-c2V2) * M/1000/m * 100-w2 * 1.126 formula (1)
Qhov twg:
V1: Ntim ntawm nyiaj nitrate txheem titration tov (ml)
V2: Ntim ntawm ammonium thiocyanate txheem titration tov noj los ntawm titration (ml)
c1: Tus nqi ntawm cov nyiaj nitrate txheem titration tov (mol/L)
c2: Tus nqi ntawm ammonium thiocyanate txheem titration tov (mol/L)
w2: Feem ntau (%) ntawm glycine hydrochloride cov ntsiab lus raws li tau txiav txim hauv Tshooj 4.2
M: Molar loj ntawm glycine methyl ester hydrochloride (g / mol)
1.126: Kev hloov pauv coefficient ntawm glycine hydrochloride rau Glycine methyl ester hydrochloride.
Tus lej ntsuas tus nqi ntawm ob qhov kev ntsuas qhov sib npaug tau raug coj los ua qhov ntsuas qhov ntsuas, thiab qhov sib txawv kiag li ntawm ob qhov kev ntsuas qhov sib npaug tsis ntau tshaj 0.05%.
2) Kev txiav txim siab ntawm glycine hydrochloride cov ntsiab lus
2.1 Method
Siv dimethyl daj ua qhov taw qhia, tus qauv tau titrated nrog sodium hydroxide tus qauv titrating tov, thiab lub ntim ntawm cov tshuaj tau titrated raws li kev noj ntawm sodium hydroxide tus qauv.
Xam cov ntsiab lus glycine hydrochloride.
2.2 Reagents
Txheem titration tov ntawm sodium hydroxide: c (NaOH) = 0.1mol / L
Dimethyl daj qhia kua: 10 g / L
2.3 Cov txheej txheem tsom xam
Qhov hnyav txog 5.0 g cov qauv kuaj, raug rau 0.0001g, rau hauv 200 ml beaker, yaj nrog 50ml dej, thiab ntxiv 5 tee ntawm dimethyl
Yellow indication kua, nrog sodium hydroxide standard titration tov titration kom txog rau thaum cov tshuaj los ntawm liab mus rau txiv kab ntxwv daj yog qhov kawg point.
2.4 Kev xam pom
Qhov loj feem w2 ntawm glycine hydrochloride cov ntsiab lus yog qhia raws li % thiab xam raws li qhov sib npaug (2):
w2 = (V/1000)cM/m * 100 formula (2)
Qhov twg:
V: Volume ntawm sodium hydroxide standard titration tov (mL)
c: Tus nqi ntawm sodium hydroxide standard titration tov concentration (mol / L)
M: Molar loj ntawm glycine hydrochloride (g / mol)
m: Qhov loj ntawm tus qauv (g)
Tus lej ntsuas tus nqi ntawm ob qhov kev ntsuas qhov sib npaug tau muab coj los ntsuas raws li qhov ntsuas tau, thiab qhov sib txawv kiag li ntawm ob qhov kev ntsuas qhov sib npaug tsis ntau tshaj 0.05%.
3. Melting point: Raws li tus txheej txheem ntawm melting point kev txiav txim (Suav Pharmacopoeia 2010 Appendix VIC), lub melting point range yog 172-178 ºC.
4. Kev ziab kom qhuav: nqa cov khoom no ntawm 105.0 ℃ thiab qhuav kom qhov hnyav tas li.Qhov hnyav poob yuav tsum tsis pub tshaj 0.5%.
5. Cia: Cov khoom no yuav tsum tau txias kom deb ntawm lub teeb.