H-Gly-Ome · HCl CAS 5680-79-5 Glycine Methyl Ester Hydrochloride Assay > 99.0%
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom ntawm Glycine Methyl Ester Hydrochloride (H-Gly-Ome·HCl) (CAS: 5680-79-5) nrog cov khoom zoo.Ruifu Chemical muab ntau cov amino acids thiab derivatives.Peb tuaj yeem muab kev xa khoom thoob ntiaj teb, me me thiab ntau qhov ntau.Yuav H-Gly-Ome ·HCl,Please contact: alvin@ruifuchem.com
Tshuaj npe | Glycine Methyl Ester Hydrochloride |
Synonyms | H-Gly-Ome · HCl;Gly-Ome · HCl;Methyl Glycinate Hydrochloride;Methyl Glycinate HCl;Aminoacetic Acid Methyl Ester Hydrochloride;Glycinate Methyl Ester Hydrochloride |
Tshuag xwm txheej | Hauv Tshuag, Muaj Peev Xwm Ntau Lawm 30 Tons ib Hlis |
CAS Nr | 5680-79-5 : kuv |
Molecular Formula | C3H7NO2 · HCl |
Molecular Luj | 125.55 g / mol |
Melting Point | 170.0 ~ 178.0 ℃ |
Qhov ntom | 1.000 |
rhiab heev | Moisture Sensitive |
Solubility hauv dej | Soluble hauv dej, Yuav luag Transparency |
Solubility | Soluble hauv Cawv |
Cia Temp. | Qhov chaw txias & qhuav (2 ~ 8 ℃) |
COA & MSDS | Muaj |
Qeb | Amino Acids thiab Derivatives |
Hom | Ruifu Tshuaj |
Cov lus hais txog kev nyab xeeb | S22 - Tsis txhob nqus plua plav.S24/25 - Tsis txhob sib cuag nrog daim tawv nqaij thiab qhov muag. | ||
WGK Germany | 3 | HS Code | 2922491990 ib |
Cov khoom | Kev soj ntsuam Standards | Cov txiaj ntsig |
Qhov tshwm sim | Dawb Crystalline hmoov | Ua raws |
Melting Point | 170.0 ~ 178.0 ℃ | 174.4 ℃ |
Poob rau ziab | ≤0.50% | 0.37% |
Hlawv Residue | ≤0.10% | <0.10% |
Sulfate (SO42-) | ≤ 0.020% | 0.013% |
Glycine Hydrochloride | ≤ 1.00% | 0.82% |
Heavy Metals (raws li Fe) | ≤10ppm | <10ppm |
Dawb Hydrochloric Acid | ≤ 0.20% | 0.162% |
H-Gly-Ome ·HCl Assay | > 99.0% (Titration los ntawm AgNO3) | 99.2% |
Loj Spectrum | Nyob rau hauv raws li tus qauv | Ua raws |
NMR Spectrum | Nyob rau hauv raws li tus qauv | Ua raws |
Tus nqi PH (15% Dej / 25 ℃) | 1.0 ~ 2.0 | Ua raws |
Xaus | Cov khoom tau raug kuaj & ua raws li cov specifications |
Pob: Fluorinated Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, lossis raws li cov neeg siv khoom xav tau.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov txias thiab qhuav (2 ~ 8 ℃) warehouse kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
1. Khoom: Cov khoom no yuav tsum yog cov hmoov dawb crystalline hmoov.
2. Assay:
1) Kev txiav txim siab ntawm Glycine Methyl Ester Hydrochloride kev soj ntsuam
1.1 Txoj kev
Nyob rau hauv acidic tej yam kev mob, tus qauv reacts nrog ib tug npaum li cas ntawm cov nyiaj nitrate, thiab cov nyiaj nitrate tshaj yog revertitrated nrog ammonium thiocyanate, xa mus rau ammonium ferric sulfate.
Raws li qhov taw qhia, tag nrho cov ntsiab lus chlorine tau txiav txim siab raws li qhov ntim ntawm cov qauv kev daws teeb meem, thiab tag nrho cov ntsiab lus chlorine raug rho tawm los ntawm cov ntsiab lus ntawm glycine hydrochloride kom tau txais Glycine Methyl Ester Hydrochloride cov ntsiab lus.
1.2 Reagents
Dibutyl phthalate;
Nitric acid daws: 2 + 3;
Silver nitrate txheem titration tov: c(AgNO3) = 0.1 mol/L
Ammonium thiocyanate txheem titration tov: c(NH4SCN) = 0.1 mol/L
Ammonium ferric sulfate (III) qhia kua: 80 g / L
1.3 Cov txheej txheem tsom xam
Qhov hnyav txog 0.5g qauv, raug rau 0.0001g.Muab tso rau hauv 250ml conical flask, yaj hauv 40ml dej, ntxiv 10 ml nitric acid tov, Ntxiv (50 ± 0.02) mL silver nitrate standard titration tov, 3mL ammonium ferric sulfate qhia tshuaj, 4mL dibutyl phthalate, thiab thiocyanate Ammonium standard titration tov yog titrated kom txog thaum cov tshuaj yog lub teeb xim av thiab tseem tsis muaj xim rau 30 s.
1.4 Cov txiaj ntsig suav
Qhov loj feem ntawm glycine methyl ester hydrochloric acid cov ntsiab lus w1, uas yog qhia raws li %, yog xam raws li Equation (1):
w1 = (c1V1-c2V2) * M/1000/m * 100-w2 * 1.126 formula (1)
Qhov twg:
V1: Ntim ntawm nyiaj nitrate txheem titration tov (ml)
V2: Ntim ntawm ammonium thiocyanate txheem titration tov noj los ntawm titration (ml)
c1: Tus nqi ntawm cov nyiaj nitrate txheem titration tov (mol/L)
c2: Tus nqi ntawm ammonium thiocyanate txheem titration tov (mol/L)
w2: Feem ntau (%) ntawm glycine hydrochloride cov ntsiab lus raws li tau txiav txim hauv Tshooj 4.2
M: Molar loj ntawm glycine methyl ester hydrochloride (g / mol)
1.126: Kev hloov pauv coefficient ntawm glycine hydrochloride rau Glycine methyl ester hydrochloride.
Tus lej ntsuas tus nqi ntawm ob qhov kev ntsuas qhov sib npaug tau raug coj los ua qhov ntsuas qhov ntsuas, thiab qhov sib txawv kiag li ntawm ob qhov kev ntsuas qhov sib npaug tsis ntau tshaj 0.05%.
2) Kev txiav txim siab ntawm glycine hydrochloride cov ntsiab lus
2.1 Method
Siv dimethyl daj ua qhov taw qhia, tus qauv tau titrated nrog sodium hydroxide tus qauv titrating tov, thiab lub ntim ntawm cov tshuaj tau titrated raws li kev noj ntawm sodium hydroxide tus qauv.
Xam cov ntsiab lus glycine hydrochloride.
2.2 Reagents
Txheem titration tov ntawm sodium hydroxide: c (NaOH) = 0.1mol / L
Dimethyl daj qhia kua: 10 g / L
2.3 Cov txheej txheem tsom xam
Qhov hnyav txog 5.0 g cov qauv kuaj, raug rau 0.0001g, rau hauv 200 ml beaker, yaj nrog 50ml dej, thiab ntxiv 5 tee ntawm dimethyl
Yellow indication kua, nrog sodium hydroxide standard titration tov titration kom txog rau thaum cov tshuaj los ntawm liab mus rau txiv kab ntxwv daj yog qhov kawg point.
2.4 Kev xam pom
Qhov loj feem w2 ntawm glycine hydrochloride cov ntsiab lus yog qhia raws li % thiab xam raws li qhov sib npaug (2):
w2 = (V/1000)cM/m * 100 formula (2)
Qhov twg:
V: Volume ntawm sodium hydroxide standard titration tov (mL)
c: Tus nqi ntawm sodium hydroxide standard titration tov concentration (mol / L)
M: Molar loj ntawm glycine hydrochloride (g / mol)
m: Qhov loj ntawm tus qauv (g)
Tus lej ntsuas tus nqi ntawm ob qhov kev ntsuas qhov sib npaug tau muab coj los ntsuas raws li qhov ntsuas tau, thiab qhov sib txawv kiag li ntawm ob qhov kev ntsuas qhov sib npaug tsis ntau tshaj 0.05%.
3. Melting point: Raws li tus txheej txheem ntawm melting point kev txiav txim (Suav Pharmacopoeia 2010 Appendix VIC), lub melting point range yog 172-178 ºC.
4. Kev ziab kom qhuav: nqa cov khoom no ntawm 105.0 ℃ thiab qhuav kom qhov hnyav tas li.Qhov hnyav poob yuav tsum tsis pub tshaj 0.5%.
5. Cia: Cov khoom no yuav tsum tau txias kom deb ntawm lub teeb.
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Glycine Methyl Ester Hydrochloride (H-Gly-Ome·HCl) (CAS: 5680-79-5) yog cov khoom siv raw rau cov tshuaj tua kab hauv tsev, pyrethroids, thiab cov khoom siv raw rau kev lag luam kws tshuaj.glycine methyl ester hydrochloride yog ib qho tseem ceeb nruab nrab ntawm kev npaj ntawm chrysanthemum acid thiab dichloro-Chrysanthemum acid, thiab kuj yog ib qho nruab nrab ntawm fungicide isourea.siv los ua tshuaj tua kab hauv tsev, pyrethroid raw cov ntaub ntawv thiab kev lag luam tshuaj raw cov ntaub ntawv siv hauv tshuaj, zaub mov, organic synthesis, thiab lwm yam.
Txoj kev tsim khoom yuav raug npaj siv glycine lossis chloroacetic acid ua cov khoom pib.Raws li tau piav qhia hauv qab no.Glycine raws li raw cov ntaub ntawv nrog qhuav hydrogen chloride roj rau hauv anhydrous ethanol, thawj zaug ua rau hydrogen chloride ethanol tov, thiab ces ntxiv glycine, cua sov thiab nplawm rau esterification, cov tshuaj tiv thaiv kub ntawm 80 ~ 85 ℃, tom qab glycine tau yaj tag, qhov sib tov tau nplawm rau ob peb feeb, thiab cov tshuaj tiv thaiv tau hloov mus rau lub lauj kaub crystallization thaum kub, txias kom crystallize, thiab lim kom tau glycine ethyl ester hydrochloride.Kev sib npaug ntawm cov tshuaj tiv thaiv: NH2CH2COOH C2H5O [HCl] → NH2CH2COOC2H5 · HCl kuj tuaj yeem ntxiv nrog glycine thiab anhydrous ethanol nyob rau hauv lub reactor nrog nplawm, rhuab mus rau 60 ℃, hydrogen chloride gas, hydrogen chloride yog dhau mus rau qhov kawg taw tes thaum lub reactant yog tag. thiab hydrogen chloride txuas ntxiv mus recrystallize.Cov tshuaj tiv thaiv yog pauv mus rau crystallization lauj kaub, thiab cov crystallization yog txias thaum stirring, lim, ntxuav nrog kiag li ethanol, glycine ethyl ester hydrochloride tau los ntawm ziab.Chloroacetic acid ua raw khoom rau chloroacetic acid, urotropine thiab anhydrous ethanol tau ntxiv rau lub reactor, ntawm 45 ℃ thaum tib neeg ammonia, pH = 8 ~ 8.5, tswj tus nqi ntawm ammonia, thiaj li yuav tswj cov tshuaj tiv thaiv kub ntawm 40 txog 65 ℃ Tom qab cov roj ammonia dhau lawm, cov tshuaj tiv thaiv tau khaws cia ntawm 65 ℃.Rau 1H, thiab tom qab ntawd qhov kub thiab txias tau qis rau 30 ℃, thiab cov tshuaj hydrogen chloride-anhydrous ethanol tau ntxiv cov tshuaj dropwise.Tom qab lub dropwise ntxiv, react ntawm 70 ℃ rau 2H, thiab ces lim ntawm 62 ~ 65 ℃ thaum kub kom cais ammonium chloride crystals.Cov lim dej yog muab tso rau hauv lub lauj kaub crystallization, txias rau 10 ℃, thiab nplawm, ntug crystallization, Crystal filtration, ziab rau glycine ethyl ester hydrochloride.Reaction Equation: ClCH2COOH NH3 [ethanol] → NH2CH2COOH[C2H5OH] → [HCl]NH2CH2COOH · HCl, methyl glycinate hydrochloride tuaj yeem tau los ntawm kev hloov ethanol nrog methanol.Reaction equation: NH2CH2COOH CH3OH[HCl] → NH2CH2COOCH3 · HCl
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