Histamine Dihydrochloride CAS 56-92-8 Assay 98.5 ~ 101.0% (Titration) Hoobkas
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom thiab cov chaw muag khoom ntawm Histamine Dihydrochloride (CAS: 56-92-8) nrog cov khoom zoo.Cov khoom nyoosL-Histidine (H-His-OH) (CAS: 71-00-1)Peb tuaj yeem muab kev xa khoom thoob ntiaj teb, me me thiab ntau qhov ntau.Yog tias koj txaus siab rau Histamine Dihydrochloride,Please contact: alvin@ruifuchem.com
| Tshuaj npe | Histamine Dihydrochloride |
| Synonyms | Histamine 2 HCl;Histamine DiHCl;2-(4-Imidazolyl) ethylamine Dihydrochloride;2-(1H-Imidazol-4-yl) ethylamine Dihydrochloride;2-(1H-Imidazol-4-yl) ethylamine Dihydrochloride;1H-Imidazole-4-ethanamine Dihydrochloride;Ceplene;Peremin |
| Tshuag xwm txheej | Hauv Tshuag, Muaj Peev Xwm Ntau Lawm 20 Tons ib Hlis |
| CAS Nr | 56-92-8 |
| Molecular Formula | C5H9N3 · 2 HCl |
| Molecular Luj | 184.06 Nws |
| Melting Point | 247.0 ~ 249.0 ℃ (lit.) |
| Qhov ntom | 1.14 |
| rhiab heev | Hygroscopic |
| Dej Solubility | Ua tiav Soluble hauv dej, Yuav luag Transparency |
| Solubility | Soluble hauv Methanol, Soluble hauv Ethanol, Insoluble hauv Ether |
| Cia Temp. | Muab ntim rau hauv Qhuav, Khaws ntawm Chav Kub |
| COA & MSDS | Muaj |
| Hom | Ruifu Tshuaj |
| Hazard Codes | Xn, xis | RTECS | MS 1575000 |
| Risk Statements | 36/37/38-42/43-42-22 ib | F | 1-8-9 |
| Cov lus hais txog kev nyab xeeb | 22-26-36/37/39-45-37-36/37 ib | TSCA | Yog lawm |
| RIDADR | ib 3335 | Hazard Class | Irritant |
| WGK Germany | 2 | HS Code | 293390099 ib |
| Cov khoom | Kev soj ntsuam Standards | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb Crystals los yog Crystalline Hmoov | Ua raws |
| Kev txheeb xyuas | Infrared Absorption Spectrum yog tsim | Ua raws |
| Qhov tshwm sim ntawm kev daws teeb meem | Ntshiab | Hla |
| Histidine (TLC) | Tsis raug ntes | Ua raws |
| Sulfate (SO4) | ≤ 0.020% | <0.020% |
| Hlau (Fe) | ≤10ppm | <10ppm |
| Heavy Metals (Pb) | ≤10ppm | <10ppm |
| Arsenic (As2O3) | ≤10ppm | <10ppm |
| Poob rau ziab | ≤0.50% | 0.24% |
| Sulfated tshauv | ≤ 0.20% | 0.06% |
| Assay | 98.5-101.0% (los ntawm Titration) | 99.36% |
| Tus nqi pH | 2.85 txog 3.60 (10% aq. Solution) | 3.16 |
| Xaus | Ua raws li tus qauv ntawm AJI97, EP9.0 | |
| Kev siv tseem ceeb | Amino Acids;Khoom noj khoom haus additives;Pharmaceutical Intermediates | |
Raw Materials thiab Solvents koom nrog hauv cov txheej txheem Synthesis
Cov ntaub ntawv raw:
L-Histidine (H-His-OH) CAS 71-00-1
Tom ntej: Acetophenone CAS 98-86-2
Hydrochloric Acid CAS 7647-01-0
Cov kuab tshuaj
Diethylene Glycol CAS 111-46-6
Ethanol CAS 64-17-5
Isopropyl cawv CAS 67-63-0
Dej
Histamine Dihydrochloride (CAS: 56-92-8) EP9.0 VolumeⅡTest Method
DEFINITION
Histamine dihydrochloride muaj tsis tsawg dua 98.5 feem pua thiab tsis ntau tshaj qhov sib npaug ntawm 101.0 feem pua ntawm 2-(1H-imidazol-4-yl) ethan-1-amine dihydrochloride, xam nrog rau cov khoom qhuav.
CEEB TOOM
Ib qho dawb los yog yuav luag dawb, crystalline hmoov los yog tsis muaj xim muaju, hygroscopic, soluble hauv dej, soluble hauv cawv.
IDENTIFICATION
Kev txheeb xyuas thawj zaug: A, D.
Kev qhia thib ob: B, C, D
A. Tshawb xyuas los ntawm infrared absorption spectrophotometry (2.2.24), piv nrog cov spectrum tau nrog histamine dihydrochloride CRS.Tshawb xyuas raws li cov discs npaj siv 1 mg ntawm cov khoom.
B. Tshawb xyuas cov chromatograms uas tau txais hauv kev sim rau histidine.Qhov chaw tseem ceeb hauv chromatogram tau txais nrog cov tshuaj ntsuam xyuas (b) zoo ib yam hauv txoj hauj lwm, xim thiab qhov loj me rau qhov chaw tseem ceeb hauv chromatogram tau nrog kev siv tshuaj (a).
C. Dissolve 0.1 g hauv 7 mL dej R thiab ntxiv 3 mL ntawm ib 200 g / L tov ntawm sodium hydroxide R. Dissolve 50mg ntawm sulfanilic acid R nyob rau hauv ib tug sib tov ntawm 0.1 mL ntawm hydrochloric acid R thiab 10 mL dej R thiab ntxiv 0.1 mL ntawm sodium nitrite tov R. Ntxiv cov tshuaj thib ob rau thawj zaug thiab sib tov.Cov xim liab yog tsim.
D. Nws muab cov tshuaj tiv thaiv (a) ntawm chlorides (2.3.1).
KEV KAWM
Kev daws S. Dissolve 0.5g hauv dej tsis muaj carbon dioxide R npaj los ntawm cov dej distilled R thiab dilute mus rau 10 mL nrog tib cov kuab tshuaj.
Qhov tshwm sim ntawm kev daws teeb meem.Kev daws S yog qhov tseeb (2.2.1) thiab tsis muaj xim ntau dua li siv tshuaj Y7 (2.2.2, Txoj Kev II).
pH (2.2.3).pH ntawm kev daws S yog 2.85 txog 3.60.
Histidine.Tshawb xyuas los ntawm nyias txheej chromatography (2.2.27), siv TLC silica gel G phaj R.
Test daws (a).Dissolve 0.5g ntawm cov tshuaj yuav tsum tau soj ntsuam nyob rau hauv dej R thiab dilute mus rau 10 mL nrog tib hnyav.
Test daws (b).Dilute 2 mL ntawm cov tshuaj ntsuam xyuas (a) mus rau 10 mL nrog dej R.
Kev daws teeb meem (a).Dissolve 0.1 g ntawm histamine dihydrochloride CRS hauv dej R thiab dilute mus rau 10 mL nrog tib cov kuab tshuaj.
Kev daws teeb meem (b).Dissolve 50 mg ntawm histidine monohydrochloride R hauv dej R thiab dilute rau 100 mL nrog tib cov kuab tshuaj.
Kev daws teeb meem (c).Sib tov 1 mL ntawm kev tshuaj ntsuam (a) thiab 1 mL ntawm kev siv tshuaj (b).
Siv rau lub phaj 1 μL ntawm kev xeem tshuaj (a), 1 μL ntawm kev ntsuas tshuaj (b), 1 μL ntawm kev siv tshuaj (a), 1 μL ntawm kev siv tshuaj (b) thiab 2 μL ntawm kev siv tshuaj (c).Tsim ib txoj kev ntawm 15cm siv ib qho sib tov ntawm 5volumes ntawm concentrated ammonia R, 20 ntim dej R thiab 75 ntim ntawm acetonitrile R. Qhuav lub phaj nyob rau hauv ib tug tam sim no ntawm huab cua.Rov ua txoj kev loj hlob nyob rau hauv tib txoj kev, qhuav lub phaj nyob rau hauv ib tug curren ntawm huab cua thiab tshuaj tsuag nrog ninhydrin tov R1.Kub lub phaj ntawm 110 ° C rau 10 min.Txhua qhov chaw sib raug rau histidine hauv chromatogram tau nrog cov tshuaj ntsuam xyuas (a) tsis yog khaus ntau dua li qhov chaw hauv chromatogram tau nrog kev siv tshuaj (b) (1 feem pua).Qhov kev ntsuam xyuas tsis siv tau tshwj tsis yog tias cov chromatogram tau txais nrog kev siv tshuaj (c) qhia 2 qhov sib cais kom meej.
Sulfates (2.4.13).3mL ntawm kev daws S diluted rau 15 mL nrog dej distilled R ua raws li kev txwv kev sim rau sulfates (0.1 feem pua).
Poob ntawm ziab (2.2.32).Tsis pub ntau tshaj 0.5 feem pua, txiav txim siab ntawm 0.20 g los ntawm ziab hauv qhov cub ntawm 105 ° C.
Sulfated tshauv (2.4.14).Tsis ntau tshaj 0.1 feem pua, txiav txim siab ntawm 0.5 g.
QHIA
Dissolve 0.080 g nyob rau hauv ib tug sib tov ntawm 5.0 mL ntawm 0.01 M hydrochloric acid thiab 50 mL cawv R. Ua ib tug potentiometric titration (2.2.20), siv 0.1 M sodium hydroxide.Nyeem qhov ntim ntxiv ntawm thawj thiab thib peb cov ntsiab lus ntawm inflexion.
1 mL ntawm 0.1 M sodium hydroxide yog sib npaug rau 9.203 mg ntawm C5H11Cl2N3.
KHOOM
Khaws rau hauv ib lub thawv airtight, tiv thaiv los ntawm lub teeb.
Pob: Fluorinated Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, lossis raws li cov neeg siv khoom xav tau.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias, qhuav thiab cua tshuab kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
Daim ntawv thov ntawm Histamine Dihydrochloride (CAS: 56-92-8)
1. Histamine Dihydrochloride tau pom tias ua kom muaj nitric oxide synthetase thiab inhibit los yog inhibit lub cim ntawm reactive oxygen hom (ROS).Inhibition ntawm ROS los ntawm Histamine Dihydrochloride tso cai ua kom T hlwb thiab NK hlwb los ntawm IL-2.Hauv cov qauv nas, histamine dihydrochloride suppressed ROS tsim los ntawm Kupffer hlwb los ntawm H2 histamine receptor.Nws yog lub zog vasodilator thiab endogenous histamine receptor agonist.
2. Histamine Dihydrochloride (lub npe lag luam Ceplene) yog ntsev ntawm Histamine uas yog siv los ua tshuaj rau kev tiv thaiv kev rov qab los ntawm cov neeg mob uas tau kuaj pom tias mob myeloid leukemia (AML).
Nws yog FDA pom zoo cov khoom muaj txiaj ntsig rau kev siv tshuaj pleev ib ce thiab muaj nyob rau hauv cov khoom xws li Australian Dream Cream, uas yog siv rau kev kho mob ib ntus ntawm qhov mob me thiab mob ntawm cov leeg thiab pob qij txha cuam tshuam nrog kev mob caj dab, mob nraub qaum yooj yim, bruises, sprains, thiab hom kab mob.
3. Histamine Dihydrochloride yog siv rau kev tshem tawm thiab tiv thaiv kev rov qab los ntawm cov neeg laus uas mob ntshav qab zib mellitus (AML) tom qab kev kho thawj zaug.Cov tshuaj txo qis cov pa oxygen pawg los ntawm autophagocytes, inhibits nicotinamide adenine dichemicalbo phosphate oxidase thiab tiv thaiv interleukin-2 los ntawm activating NK hlwb thiab T hlwb.Kev txhaj tshuaj Histamine Dihydrochloride tau pom zoo raws li nws qhov kev tso tawm tiav ua ke nrog interleukin-2 txo qis kev rov qab los ntawm cov neeg mob AML.
