N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Purity
Kev muag khoom lag luam Imatinib Mesylate thiab Cov Khoom Sib Txuas Txuas:
Imatinib Mesylate CAS NO: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS: 106261-49-8
| Tshuaj npe | N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea |
| Synonyms | Imatinib Mesylate Intermediate;2-(5-Amino-2-methylanilino)-4-(3-pyridyl)pyrimidine |
| CAS Nr | 152460-10-1 |
| CAT Number | Qauv: RF-PI230 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
| Molecular Formula | C16H15N5 |
| Molecular Luj | 277.32 Nws |
| Melting Point | 133.0-135.0 ℃ |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Lub teeb Txiv kab ntxwv rau daj hmoov rau Crystal |
| Purity / Analysis Method | ≥98.0% |
| Poob rau ziab | ≤0.50% |
| Residue ntawm ignition | ≤0.50% |
| Tag nrho cov impurities | ≤ 2.0% |
| Qhov siab tshaj plaws ib leeg impurity | ≤ 1.0% |
| Hnyav Hlau | ≤ 20ppm |
| Test Standard | Enterprise Standard |
| Kev siv | Intermediate ntawm Imatinib Mesylate (CAS: 220127-57-1) |
Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom thiab chaw muag khoom ntawm N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) nrog cov khoom zoo .
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) yog ib qho nruab nrab feem ntau hauv kev sib txuas ntawm Imatinib Mesylate (CAS: 220127-57-1) ) API.
Imatinib mesylate yog ib qho me me molecule uas inhibits c-Abl protein-tyrosine kinase, ib qho kinase tshwj xeeb rau kev loj hlob ntawm cov kab mob myelogenous leukemia (CML).Ib qho kev hloov pauv ntawm chromosomes 9 thiab 22 ua rau Philadelphia chromosome, uas tom qab ntawd ua rau Bcr-Abl fusion protein nrog aberrant kinase kev ua haujlwm uas txhawb nqa kev loj hlob sai ntawm tes.Imatinib mesylate khi rau qhov tseem ceeb kinase, txwv tsis pub CML ntsig txog kev loj hlob.Imatinib mesylate tau nthuav tawm ntxiv los inhibit PDGFR thiab tyrosine kinases txuam nrog c-Kit.Cov tshuaj uas muaj Imatinib mesylate tau siv los kho ntau yam qog noj ntshav.
Imatinib mesylate yog tyrosine kinase inhibitor.Tshwj xeeb heev rau BCR-ABL, cov enzyme cuam tshuam nrog mob myelogenous leukemia (CML) thiab qee hom mob qog ntshav qog ntshav qog ntshav (TXHW).Nws yog ib qho muaj zog thiab xaiv v-Abl tyrosine kinase inhibitor (IC50 = 38 nM).Kuj inhibits PDGFR thiab c-kit.Qhia txog kev xaiv rau v-Abl hla lub vaj huam sib luag ntawm lwm cov tyrosine thiab serine / threonine protein kinases.Selectively inhibits PDGF-stimulated kev loj hlob ntawm v-abl-transformed PB-3 hlwb thiab v-sis-transformed BALB/c 3T3 hlwb hauv vitro.Tso tawm cov teebmeem antitumor hauv cov nas uas muaj AMuLV lossis BABL/c 3T3 v-sis hlwb.Inhibits replication of SARS-CoV and MERS-CoV in vitro (EC50 values are 9.823 and 17.689 μM, respectively).
![4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS 106261-49-8 Imatinib Mesylate Intermediate High Purity](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)