Imatinib Mesylate CAS 220127-57-1 Assay 98.0% ~ 102.0% Ph + CML API Hoobkas Zoo
Kev muag khoom lag luam Imatinib Mesylate thiab Cov Khoom Sib Txuas Txuas:
Imatinib Mesylate CAS NO: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS: 106261-49-8
| Tshuaj npe | Imatinib Mesylate (alpha form) |
| Synonyms | Imatinib Methanesulfonate;STI571 Mesylate;CGP-57148B |
| CAS Nr | 220127-57-1 |
| CAT Number | RF-API 19 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
| Molecular Formula | C30H35N7O4S |
| Molecular Luj | 589.71 ib |
| Shipping Condition | Nyob rau hauv Ambient Kub |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Dawb rau Off-White Crystalline Hmoov |
| Solubility | Yooj yim rau yaj hauv dej |
| HPLC Identification | Qauv spectrum lub ntsiab ncov lub sijhawm khaws cia ua raws li qhov ntawd |
| IR Identification | Infrared absorption spectrum ntawm cov qauv ua raws li cov qauv siv |
| Melting Point | 214.0 ~ 222.0 ℃ |
| Poob rau ziab | ≤0.50% |
| Residue ntawm Ignition | ≤0.10% |
| Hnyav Hlau | ≤ 20ppm |
| Yam khoom muaj feem | (1) impurity G: NMT 0.3% |
| (2) impurity B: NMT 0.3% | |
| (3) impurity C: NMT 0.3% | |
| (4) impurity D: NMT 0.3% | |
| (5) impurity A: NMT 0.3% | |
| (6) impurity H: NMT 0.3% | |
| (7) impurity F: NMT 0.3% | |
| (8) Impurity E: NMT 0.3% | |
| (9) Qhov loj tshaj ib qho impurity: NMT0.1% | |
| Residual Solvents | (1) Ethyl Acetate: NMT 5000ppm |
| (2) Methanol: NMT3000ppm | |
| (3) Dichloromethane: NMT 600ppm | |
| (4) Ethanol: NMT 5000ppm | |
| (5) Toluene: NMT 890ppm | |
| (6) Dimethyl Sulfoxide: NMT5000ppm | |
| HPLC Assay | 98.0% ~ 102.0% (C30H35N7SO4 xam rau ntawm Anhydrous Basis) |
| Test Standard | Enterprise Standard |
| Kev siv | API;Ph + CML |
Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.
Imatinib Mesylate (CAS 220127-57-1) yog ib qho me me molecule uas inhibits c-Abl protein-tyrosine kinase, kinase tshwj xeeb tseem ceeb rau kev loj hlob ntawm cov kab mob myelogenous leukemia (CML).Tshwj xeeb heev rau BCR-ABL, cov enzyme cuam tshuam nrog mob myelogenous leukemia (CML) thiab qee hom mob qog ntshav qog ntshav qog ntshav (TXHW).Nws yog ib qho muaj zog thiab xaiv v-Abl tyrosine kinase inhibitor (IC50 = 38 nM).Ib qho kev hloov pauv ntawm chromosomes 9 thiab 22 ua rau Philadelphia chromosome, uas tom qab ntawd ua rau Bcr-Abl fusion protein nrog aberrant kinase kev ua haujlwm uas txhawb nqa kev loj hlob sai ntawm tes.Imatinib mesylate khi rau qhov tseem ceeb kinase, txwv tsis pub CML ntsig txog kev loj hlob.Imatinib mesylate tau nthuav tawm ntxiv los inhibit PDGFR thiab tyrosine kinases txuam nrog c-Kit.
![4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS 106261-49-8 Imatinib Mesylate Intermediate High Purity](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)