Inosine CAS 58-63-9 Assay 98.0 ~ 102.0% Hoobkas Zoo

Inosine (CAS: 58-63-9) ChP2020 Test Method
Inosine - KEV NTSEEG
Cov ntsiab lus ntawm C10H12N4O5 yuav tsum nyob nruab nrab ntawm 98.0% thiab 102.0% xam ntawm cov khoom qhuav.
Inosine - Cim Cov khoom no yog dawb crystalline hmoov;Tsis hnov ​​tsw.Cov khoom no yog me ntsis soluble hauv dej, insoluble hauv ethanol, thiab soluble hauv dilute hydrochloric acid thiab sodium hydroxide tov.
Inosine - IDENTIFICATION
1. Siv cov tshuaj 0.01% ntawm cov khoom no, ntxiv cov ntim sib npaug ntawm 3, 5-dihydroxytoluene tov ( noj 3, 5-dihydroxytoluene thiab ferric chloride 0.lg, ntxiv hydrochloric acid ua 100ml), sib tov zoo, tom qab ntawd cua sov hauv dej da dej li 10 feeb, pom xim ntsuab.
2. Nyob rau hauv chromatogram sau tseg nyob rau hauv cov ntsiab lus kev txiav txim cov khoom, lub sij hawm tuav ntawm lub ntsiab ncov ntawm cov tshuaj ntsuam xyuas yuav tsum tau raws li lub sij hawm tuav ntawm lub ntsiab ncov ntawm cov ntaub ntawv siv.
3. Lub infrared absorption spectrum ntawm cov khoom no yuav tsum ua raws li cov kev tswj hwm (Spectrum teeb 605).
Inosine - Kev tsom xam
Transmittance ntawm kev daws teeb meem
Noj 0.5g ntawm cov khoom no, ntxiv 50ml dej kom yaj, raws li UV-pom spectrophotometry (Txoj cai lij choj 0401), txiav txim siab qhov kev xa tawm ntawm 430nm wavelength, tsis tsawg dua 98.0%.(rau txhaj tshuaj)
Yam khoom muaj feem
Noj cov khoom no, ntxiv dej kom yaj thiab dilute los ua cov tshuaj uas muaj 0.5mg ib 1ml raws li kev sim tshuaj;Siv 1ml rau kev ntsuas qhov tseeb, muab tso rau hauv 100ml ntsuas lub khob, dilute nws nrog dej mus rau qhov ntsuas, raws li kev tswj kev daws teeb meem.Raws li cov xwm txheej chromatographic nyob rau hauv cov ntsiab lus kev txiav txim siab, 20 u1 ntawm kev ntsuas kev daws teeb meem thiab kev tswj kev daws teeb meem feem ntau raug txhaj rau hauv cov kua chromatograph, thiab chromatogram raug kaw rau 2 zaug ntawm lub sijhawm tuav ntawm lub ntsiab ncov.Yog hais tias muaj impurity peaks nyob rau hauv lub chromatogram ntawm cov tshuaj ntsuam xyuas, cov sum ntawm txhua impurity ncov cheeb tsam yuav tsum tsis txhob ntau tshaj lub ntsiab ncov cheeb tsam ntawm kev tswj cov tshuaj (1.0%).
Poob rau ziab
Noj cov khoom no, qhuav mus tas li qhov hnyav ntawm 105 ° C, qhov hnyav poob yuav tsum tsis pub tshaj 1.0% (Txoj cai 0831).
Residue ntawm Ignition (Sulfated)
Tsis ntau tshaj 0.1% (rau kev txhaj tshuaj), lossis tsis ntau tshaj 0.2% (rau kev siv qhov ncauj) (Txoj cai 0841).
Hnyav Hlau
Noj cov khoom no 1.0g, tshuaj xyuas raws li txoj cai (Cov Ntsiab Cai 0821 thib ob txoj cai), uas muaj cov hlau hnyav yuav tsum tsis pub tshaj 10 feem ntawm ib lab.
Mob toxicity
Noj cov khoom no, ntxiv cov tshuaj sodium chloride kom yaj thiab dilute cov tshuaj uas muaj inosine 10mg ib 1ml, xyuas raws li txoj cai (Txoj cai 1141), yuav tsum ua raws li cov kev cai.(rau txhaj tshuaj)
Inosine - Kev txiav txim siab txog cov ntsiab lus
Ntsuas los ntawm High Performance Liquid Chromatography (General 0512).
Chromatographic tej yam kev mob thiab system haum xeem silica gel bonded nrog kaum yim alkyl silane tau siv los ua tus muab tub lim;Methanol-dej (10:90) tau siv los ua lub sijhawm txawb;Kev kuaj pom wavelength yog 248nm.Noj li 10mg ntawm inosine siv, ntxiv 1 mol / L hydrochloric acid tov (1ml), tshav kub hauv dej da dej ntawm 80 ℃ rau 10 feeb, cia nws txias, ntxiv 1ml ntawm 1 mol / L sodium hydroxide tov, ntxiv dej rau 50ml, 20u1 txhaj tshuaj kua chromatograph, kho lub chromatographic system, kev sib cais degree ntawm inosine ncov thiab nyob ib sab impurity ncov yuav tsum tau raws li qhov yuav tsum tau, tus naj npawb ntawm theoretical phaj raws li inosine ncov xam tsis tsawg tshaj li 2000.
Assay
Siv cov khoom tsim nyog ntawm cov khoom no, ua kom raug hnyav, ntxiv dej kom yaj thiab ua kom muaj nuj nqis los ua cov tshuaj uas muaj li 20ug ib lml, co nws, thiab siv nws los ua cov tshuaj ntsuam xyuas, A 20ul txhaj tshuaj kua chromatograph raug ntsuas kom raug thiab cov chromatogram tau sau tseg.Tus nqi tsim nyog ntawm inosine siv tau raug ntsuas raug ntsuas thiab txiav txim siab los ntawm tib txoj kev, thiab thaj chaw ncov raug xam raws li tus qauv txheej txheem sab nraud.
Inosine - Qeb
Cell metabolism txhim kho cov tshuaj.
Inosine - Cia
Lub teeb shielding, kaw ruaj khov.
Pharmaceuticals: (1) Inosine Oral Solution (2) Inosine Tablets (3) Inosine Txhaj (4) Inosine Capsules (5) Inosine thiab Glucose Txhaj (6) Inosine thiab Sodium Chloride Txhaj (7) Inosine txhaj