Irbesartan CAS 138402-11-6 Purity > 99.0% (HPLC) API Hoobkas Antihypertensive
Chaw tsim khoom, siab purity, coj mus muag ntau lawm
| Tshuaj npe | Irbesartan |
| Synonyms | BMS-186295;SR-47436;Aprovel;Avapro;2-Butyl-3-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en- 4-ib;2-Butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one |
| CAS Nr | 138402-11-6 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
| Molecular Formula | C25H28N6O |
| Molecular Luj | 428.54 ib |
| Qhov ntom | 1.30 ± 0.10g / cm3 |
| Solubility hauv dej | Insoluble hauv dej |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Yam ntxwv | Dawb rau Off-White Crystalline Powder, me ntsis soluble hauv cawv thiab hauv methylene chloride, xyaum insoluble hauv dej |
| Kev txheeb xyuas Infrared Absorption | IR spectrum yog raws li cov spectrum tau nrog Irbesartan RS |
| Kev txheeb xyuas 2 | Lub sijhawm khaws cia ntawm lub ncov loj hauv chromatogram ntawm qhov kev ntsuam xyuas sib haum rau Irbesartan RS |
| Purity / Analysis Method | > 99.5% (HPLC) |
| Dej | <0.50% |
| Hnyav Hlau | <0.002% |
| Residue ntawm Ignition | <0.10% |
| Yam khoom muaj feem | (los ntawm HPLC) |
| USP impurity A | <0.20% |
| Tej yam uas tsis pom tseeb | <0.10% |
| Tag nrho cov impurities | <0.50% |
| Organic VolatileImpurities | Ua tau raws li cov cai ntawm USP |
| Residual Azide | <10ppm |
| Residual Solvents | (Los ntawm GC) |
| Ethanol | <5000ppm |
| Toluene | <890ppm |
| Dichloromethane | <3000ppm |
| N, N-Dimethylformamide | <880ppm |
| T-Butyl Methyl Ether | <5000ppm |
| Assay | 98.0 ~ 102.0% (xws li anhydrous hauv paus) |
| Test Standard | Enterprise Standard;USP Txuj |
| Kev siv | API;Antihypertensive;Rau kev kho mob ntshav siab |
Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo
Irbesartan (CAS: C) yog angiotensin II receptor antagonist siv rau kev kho mob ntshav siab.Irbesartan tau tsim los ntawm Sanofi Research (tam sim no ib feem ntawm Sanofi-Aventis).Nws tau koom ua lag luam los ntawm Sanofi-Aventis thiab Bristol-Myers Squibb nyob rau hauv lub npe lag luam Aprovel, Karvea, thiab Avapro.Irbesartan yog siv los kho cov ntshav siab.Avapro tau tsim tawm hauv Tebchaws Yelemees, UK thiab Asmeskas rau kev kub siab.Raws li nrog tag nrho cov angiotensin II receptor antagonists, irbesartan yog qhia rau kev kho mob ntshav siab.Irbesartan kuj tseem tuaj yeem ncua kev mob ntshav qab zib nephropathy thiab tseem qhia txog kev txo qis kev mob raum hauv cov neeg mob ntshav qab zib hom 2, ntshav siab thiab microalbuminuria (> 30 mg / 24 teev) lossis proteinuria.Irbesartan tseem tuaj yeem txo cov hluav taws xob hloov kho ntawm myocardium, yog li txo qis kev tuag ntawm cov neeg mob ntshav siab, nws yog cov tshuaj zoo tshaj plaws rau kev kho mob ntshav siab thiab kab mob plawv.
