Irinotecan Hydrochloride CAS 100286-90-6 Purity ≥99.0% (HPLC) API USP Standard High Purity
Chaw tsim tshuaj paus Supply Irinotecan thiab Related Intermediates:
Tom ntej: Irinotecan Hydrochloride CAS 100286-90-6
Irinotecan Dawb Base CAS: 97682-44-5
Tom ntej: Irinotecan Hydrochloride Trihydrate CAS 136572-09-3
Tom ntej: 7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
Tom ntej: 1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Tshuaj npe | Irinotecan Hydrochloride |
| Synonyms | Camptothecin II;CPT-II |
| CAS Nr | 100286-90-6 |
| CAT Number | RF-API 50 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
| Molecular Formula | C33H39ClN4O6 |
| Molecular Luj | 623.15 Nws |
| Melting Point | 250-256 ℃ (Lub Kaum Ob Hlis) |
| Kev cia khoom | Nyob rau hauv Ambient Kub |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Dawb los yog Off-White hmoov |
| Solubility | Soluble hauv dej thiab methanol, me ntsis soluble hauv chloroform, ethanol |
| Identification IR | Lub infrared absorption spectrum ntawm cov qauv xeem yuav tsum ua raws li tus qauv siv |
| Kev txheeb xyuas HPLC | Lub sijhawm khaws cia ntawm qhov tseem ceeb ncov ntawm cov qauv kev daws teeb meem yuav tsum sib haum nrog cov qauv siv. |
| Kev txheeb xyuas | Ua tau raws li qhov yuav tsum tau ua ntawm kev ntsuam xyuas rau Chloride Cov tshuaj tiv thaiv zoo |
| Moisture (KF) | 7.0% ~ 9.0% w/w |
| Residue ntawm Ignition | ≤0.10% |
| Hnyav Hlau | ≤ 20ppm |
| Irinotecan Hydrochloride Enantiomer | ≤0.10% (HPLC) |
| 7-Desethyl Irinotecan | ≤ 0.15% |
| Irinotecan Related Compound A | ≤ 0.15% |
| 11-Ethyl Irinotecan | ≤ 0.15% |
| Camptothecin | ≤ 0.15% |
| Irinotecan Related Compound B | ≤ 0.15% |
| 7-Ethylcanptothecin | ≤ 0.15% |
| 7,11-Diethyl-10-Hydroxy Camptothecin | ≤ 0.15% |
| Tej yam tsis meej tsis meej | ≤0.10% |
| Tag nrho cov impurities | ≤0.50% |
| Residual Solvents (GC) | |
| Methanol | ≤2000ppm |
| Acetone | ≤2000ppm |
| Dichloromethane | ≤ 500ppm |
| Peteoleum Ether: | ≤100ppm |
| Ethyl Acetate | ≤2000ppm |
| Benzene | ≤ 2 ppm |
| Cov kab mob endotoxins | ≤0.29 EU/mg Irinotecan |
| Microbial txwv | Tag nrho Aerobic Microbial suav: <1000 cfu/g |
| Pwm thiab Poov xab | <100 cfu/g |
| Purity / Analysis Method | ≥99.0% (HPLC, nyob rau hauv lub hauv paus anhydrous) |
| Test Standard | Teb Chaws Asmeskas Pharmacopeia (USP) Standard |
| Kev siv | Active Pharmaceutical Ingredients (API) |
Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.
lrinotecan hydrochloride (CAS 100286-90-6), semi-synthetic, dej soluble derivative ntawm lub hwj chim anticancer tus neeg sawv cev camptothecin, twb launched nyob rau hauv Nyiv rau kev kho mob ntawm lub ntsws, zes qe menyuam, thiab ncauj tsev menyuam.lrinotecan exerts nws antitumor kev ua los ntawm inhibition ntawm topoisomerase I, ib tug cellular enzyme uas koom nyob rau hauv kev tswj cov topographic qauv ntawm DNA thaum lub sij hawm tus txheej txheem ntawm kev txhais lus, transcription, thiab mitosis.lrinotecan tau dhau los ua de-esterification hauv vivo kom tau txais txiaj ntsig metabolite, SN-38, uas yog 1000-fold muaj zog dua li niam txiv.Kev sib xyaw ua ke ntawm irinotecan nrog rau lwm cov tshuaj tiv thaiv kab mob uas siv dav, cisplatin, tau raug tshaj tawm tias zoo tshaj rau tus neeg sawv cev ib leeg.Lrinotecan yog nyob rau hauv kev sim tshuaj rau plab hnyuv, lub mis, daim tawv nqaij, plab hnyuv siab raum, qog nqaij hlav pancreatic, mesothelioma thiab non-Hodgkin's lymphoma.
