Irinotecan Hydrochloride Trihydrate CAS 136572-09-3 API Hoobkas High Purity
Chaw tsim tshuaj paus Supply Irinotecan thiab Related Intermediates:
Tom ntej: Irinotecan Hydrochloride CAS 100286-90-6
Irinotecan Dawb Base CAS: 97682-44-5
Tom ntej: Irinotecan Hydrochloride Trihydrate CAS 136572-09-3
Tom ntej: 7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
Tom ntej: 1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Tshuaj npe | Irinotecan Hydrochloride Trihydrate |
| Synonyms | Irinotecan HCl Trihydrate;CPT-11 Trihydrate;Tom ntej: Irinotecan HCL 3H2O |
| CAS Nr | 136572-09-3 |
| CAT Number | RF-API 52 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
| Molecular Formula | C33H38N4O6 · HCl · 3H2O |
| Molecular Luj | 677.20 ib |
| Melting Point | 250.0 ~ 256.0 ℃ (txog.) |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Lub teeb daj lossis daj crystalline hmoov |
| Assay (w/w) | 98.0% ~ 102.0%. |
| Purity (HPLC) | ≥99.5% |
| Solubility | Me ntsis soluble hauv dej, ethanol lossis chloroform, Xyaum Insoluble hauv acetone |
| Kev txheeb xyuas | los ntawm IR thiab HPLC, Conforms |
| Specific Optical Rotation | +60 ° ~ + 73 ° |
| Dej | 7.0% ~ 9.0%. |
| Residue ntawm Solvents | Ua raws li ICH Requirements |
| Residue ntawm Ignition | ≤ 0.20% |
| Chloride | 5.0% ~ 6.0% |
| Tus nqi pH | 3.0 ~ 5.0 |
| Hnyav Hlau | ≤ 20ppm |
| Tus kheej impurities | ≤0.10% |
| Tag nrho cov impurities | ≤0.50% |
| Kev cia khoom | Khaws ntawm 2-8 ° C, hauv cov thawv ntim thiab tiv thaiv los ntawm lub teeb thiab noo noo |
| Test Standard | Enterprise Standard |
| Kev siv | Active Pharmaceutical Ingredients (API) |
Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom thiab cov chaw muag khoom ntawm Irinotecan Hydrochloride Trihydrate (CAS: 136572-09-3) nrog cov khoom zoo.
Irinotecan Hydrochloride Trihydrate yog ib qho topoisomerase I inhibitor tsuas yog siv los kho mob qog noj ntshav thiab mob qog noj ntshav, tiv thaiv kev ntseeg ntawm DNA strand los ntawm kev khi rau topoisomerase I-DNA complex.lrinotecan hydrochloride, ib tug semi-synthetic, dej soluble derivative ntawm lub hwj chim anticancer tus neeg sawv cev camptothecin, twb launched nyob rau hauv Nyiv rau kev kho mob ntawm lub ntsws, zes qe menyuam, thiab ncauj tsev menyuam.lrinotecan exerts nws antitumor kev ua los ntawm inhibition ntawm topoisomerase I, ib tug cellular enzyme uas koom nyob rau hauv kev tswj cov topographic qauv ntawm DNA thaum lub sij hawm tus txheej txheem ntawm kev txhais lus, transcription, thiab mitosis.lrinotecan tau dhau los ua de-esterification hauv vivo kom tau txais txiaj ntsig metabolite, SN-38, uas yog 1000-fold muaj zog dua li niam txiv.Txawm hais tias tsis muaj tshuaj lom ntau dua li camptothecin, ntau tus neeg mob hauv kev sim tshuaj ntsuam xyuas pom muaj kev phiv ntawm leukopenia, raws plab, xeev siab, thiab alopecia.Kev sib xyaw ua ke ntawm irinotecan nrog rau lwm cov tshuaj tiv thaiv kab mob uas siv dav, cisplatin, tau raug tshaj tawm tias zoo tshaj rau tus neeg sawv cev ib leeg.Lrinotecan yog nyob rau hauv kev sim tshuaj rau plab hnyuv, lub mis, daim tawv nqaij, plab hnyuv siab raum, qog nqaij hlav pancreatic, mesothelioma thiab non-Hodgkin's lymphoma.
