Ketorolac Tromethamine CAS 74103-07-4 Purity > 99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom thiab cov chaw muag khoom ntawm Ketorolac Tromethamine Salt (CAS: 74103-07-4) nrog cov khoom zoo.Peb tuaj yeem muab COA, xa khoom thoob ntiaj teb, me me thiab ntau ntau.Yog tias koj txaus siab rau cov khoom no, thov xa cov ncauj lus kom ntxaws suav nrog CAS naj npawb, cov khoom npe, kom muaj nuj nqis rau peb.Please contact: alvin@ruifuchem.com
| Tshuaj npe | Ketorolac Tromethamine |
| Synonyms | Ketorolac Tris ntsev;Ketorolac (Tromethamine ntsev);rac Ketorolac Tromethamine ntsev;Toradol;(±)-5-Benzoyl-2,3-Dihydro-1H-Pyrrolizine-1-Carboxylic Acid Tris ntsev;(±)-Form Tromethamine ntsev |
| CAS Nr | 74103-07-4 ib |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, Commercially Manufactured |
| Molecular Formula | C15H13NO3 · C4H11NO3 |
| Molecular Luj | 376.41 ib |
| Melting Point | 160.0 ~ 161.0 ℃ |
| Boiling Point | 493.2 ℃ ntawm 760 mmHg |
| rhiab heev | Hygroscopic.Lub teeb Sensitive |
| lw max | 322nm (MeOH) (lit.) |
| COA & MSDS | Muaj |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Dawb rau Off-White Crystalline Hmoov |
| pH | 5.7-6.7 Nws |
| Melting Point | 160.0 ~ 161.0 ℃ |
| Purity / Analysis Method | > 99.0% (HPLC) |
| Assay / Analysis Method | 98.5 ~ 101.5% (Xam rau ntawm Kev Qhuab Qhia) |
| Poob rau ziab | <0.50% |
| Residue ntawm Ignition | <0.10% |
| Heavy Metals (Pb) | ≤ 20ppm |
| Yam khoom muaj feem | |
| Qhov tsis zoo RRT0.54 | <0.50% |
| Kev tsis ncaj ncees RRT0.66 | <0.50% |
| Ketorolac 1-Keto Analog | <0.10% |
| Ketorolac 1-Hydroxy Analog | <0.10% |
| Lwm Yam Ib Leeg Impurity | <0.20% |
| Tag nrho cov impurities | <1.00% |
| Residual Solvents | |
| Dichloroethane | <50 ppm |
| Anhydrous Ethanol | <5000ppm |
| Microorganism txwv | |
| Cov kab mob | <1000cfu/g |
| Pwm thiab Pwm Tus Nqi | <100cfu/g |
| Escherichia.Coli | Tsis muaj |
| Cov kab mob endotoxin | <5EU/mg |
| Infrared Spectrum | Raws li tus qauv |
| Solubility hauv H2O | Colorless to Faint Yellow Clear (15 mg/ml) Pass |
| Test Standard | Enterprise Standard |
Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv lub thawv kaw nruj nreem.Khaws rau hauv qhov chaw txias, qhuav (2 ~ 8 ℃) thiab lub tsev tso cua txias kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
Ketorolac Tromethamine Salt (CAS: 74103-07-4) yog ib tug nonsteroidal antiinflammatory tus neeg sawv cev uas nthuav tawm analgesic thiab antipyretic kev ua si.Nws yog ib qho tsis xaiv COX inhibitor nrog IC50s ntawm 20 nM rau COX-1 thiab COX-2.Ketorolac Tromethamine Salt muaj txiaj ntsig zoo hauv kev tswj cov mob nruab nrab mus rau mob hnyav tom qab phais.Nws yog, txawm li cas los xij, thawj hom ntawm tus neeg sawv cev no yuav tsum tau tswj hwm los ntawm parenterally raws li kev kho mob thiab tshwj xeeb qhia rau kev txhaj tshuaj intramuscular.Ketorolac sawv cev rau lwm txoj hauv kev rau cov tshuaj narcotic analgesics vim nws tsis muaj peev xwm tsim txom.Nws yog siv feem ntau rau nws cov teebmeem analgesic rau kev kho mob luv luv ntawm mob me mus rau nruab nrab hauv dev thiab nas.Lub sijhawm ntawm cov nyhuv analgesic hauv dev yog li 8-12 teev, tab sis vim tias muaj kev pom zoo, muaj kev nyab xeeb NSAIDs rau dev, nws siv yog nug.Ib qho organoammonium ntsev uas tshwm sim los ntawm kev sib xyaw ntawm equimolar nqi ntawm ketorolac thiab tromethamine (tris).Nws muaj zog tsis-sedating analgesic thiab nruab nrab los tiv thaiv inflammatory.Nws yog siv nyob rau hauv kev tswj lub sij hawm luv luv ntawm kev mob tom qab phais, thiab nyob rau hauv lub qhov muag tee los txo cov ocular khaus txuam nrog raws caij nyoog allergic conjunctivitis.
Hazard Symbols T - Toxic
Risk Codes
R25 - Toxic yog nqos
R36/37/38 - Kab mob rau qhov muag, ua pa thiab tawv nqaij.
R23/24/25 - Toxic los ntawm kev nqus pa, tiv tauj nrog daim tawv nqaij thiab yog tias nqos.
Kev nyab xeeb piav qhia
S26 - Nyob rau hauv rooj plaub ntawm qhov muag, yaug tam sim ntawd nrog dej txaus thiab nrhiav kev kho mob.
S45 - Thaum muaj xwm txheej lossis yog tias koj tsis xis nyob, nrhiav kev kho mob tam sim ntawd (qhia daim ntawv lo thaum twg los tau.)
S36/37/39 - Hnav cov khaub ncaws tiv thaiv, hnab looj tes thiab tiv thaiv qhov muag / ntsej muag.
UN IDs UN 2811 6.1/PG 3
WGK Germany 3
RTECS UY7759900
HS Code 2933995500
Hazard Class 6.1(a)
Packing Group II
Ketorolac Tromethamine muaj tsis pub tsawg tshaj 98.5 feem pua thiab tsis ntau tshaj 101.5 feem pua ntawm C15H13NO3·C4H11NO3, xam rau ntawm qhuav hauv paus.
Ntim thiab khaws cia-Txuag hauv cov thawv nruj, lub teeb-tiv taus.Khaws ntawm 25 °, kev ncig ua si tso cai ntawm 15 ° thiab 30 °
USP Reference cov qauv <11>-
USP Ketorolac Tromethamine RS
Kev txheeb xyuas-
A: Infrared Absorption <197K>.
B: Ultraviolet Absorption <197U>-
Kev daws: 10 µg per mL
Medium: methanol.
C: Tromethamine test-Npaj tus qauv kev daws teeb meem ntawm USP Ketorolac Tromethamine RS hauv kev sib xyaw ntawm dichloromethane thiab methanol (2: 1) uas muaj 5 mg rau ib mL.Ib yam li ntawd, npaj ib qho kev sim tshuaj ntawm Ketorolac Tromethamine uas muaj 5 mg ib mL.Siv 40-µL ntim ntawm Standard tov thiab cov tshuaj ntsuam xyuas rau nyias txheej chromatographic phaj (saib Chromatography <621>) coated nrog 0.25-mm txheej ntawm chromatographic silica gel sib tov.Muab lub phaj tso rau hauv lub chromatographic chamber yav tas los sib npaug nrog cov sib xyaw ntawm dichloromethane, acetone, thiab glacial acetic acid (95: 5: 2).Kaw lub chamber, thiab tsim cov chromatogram kom txog thaum lub qhov hnyav pem hauv ntej tau txav mus txog peb feem plaub ntawm qhov ntev ntawm lub phaj.Tshem lub phaj ntawm lub chamber, thiab cia cov kuab tshuaj evaporate.Txau lub phaj nrog cov kua dej tshiab tshiab uas muaj 30 mg ntawm ninhydrin ib mL, thiab kub lub phaj ntawm li 150 ° rau 2 mus rau 5 feeb.Cov pob daj nrog cov paj yeeb rau cov ciam teb liab doog tsim ntawm lub phaj nyob rau hauv cov cheeb tsam uas siv cov tshuaj Standard thiab cov tshuaj ntsuam xyuas.
pH <791>: nruab nrab ntawm 5.7 thiab 6.7, hauv kev daws (1 ntawm 100).
Poob ntawm ziab <731>-Sry hauv lub tshuab nqus tsev ntawm 60 ° rau 3 teev: nws poob tsis ntau tshaj 0.5% ntawm nws qhov hnyav.
Residue ntawm ignition <281>: tsis ntau tshaj 0.1%.
Cov hlau hnyav, Txoj Kev II <231>: 0.002%.
Chromatographic purity-
Mobile theem, hnyav sib tov, Standard npaj, kev daws teeb meem, thiab Chromatographic system-Tom ntej raws li qhia nyob rau hauv Assay.
Test solution-Siv qhov Assay npaj.
Procedure-Chromatograph Test Solution raws li qhia rau Cov Txheej Txheem hauv Kev Ntsuas, tso cai rau cov chromatography txuas mus rau peb npaug ntawm lub sijhawm khaws cia ntawm ketorolac.Ntsuas cov lus teb ntawm tag nrho cov peaks.Xam cov feem pua ntawm txhua tus neeg tsis huv hauv ib feem ntawm Ketorolac Tromethamine coj los ntawm cov mis:
100rfi (ri / rs)
nyob rau hauv uas rfi yog cov lus teb ntawm txhua tus neeg impurity ncov txheeb ze ntawm ketorolac;ri yog lub ncov teb rau txhua impurity;thiab rs yog cov lej ntawm tag nrho cov lus teb ncov ntawm lub ncov impurity thiab lub ncov loj ketorolac.rfi qhov tseem ceeb yog 0.52 rau ketorolac 1-keto analog, 0.67 rau ketorolac 1-hydroxy analog, 2.2 rau lub ncov impurity muaj lub sij hawm tuav ntawm 0.54 txheeb ze ntawm ketorolac, thiab 0.91 rau lub impurity ncov ntawm ib tug txheeb ze tuav lub sij hawm. ua 0,66.Tsis pub ntau tshaj 0.1% ntawm ketorolac 1-keto analog lossis ntawm ketorolac 1-hydroxy analog yog pom;tsis pub ntau tshaj 0.5% ntawm lwm yam impurity pom;thiab tag nrho cov impurities tsis ntau tshaj 1.0%.
Assay-
Txawb theem-Dissolve 5.75 g ntawm monobasic ammonium phosphate hauv 1000 mL dej, thiab kho nrog phosphoric acid rau pH ntawm 3.0.Npaj ib qho dej lim thiab degassed sib tov ntawm cov tshuaj tsis haum no thiab tetrahydrofuran (70:30).Hloov kho yog tias tsim nyog (saib System Suitability hauv Chromatography <621>) kom ua tiav lub sijhawm khaws cia rau ketorolac li ntawm 8 txog 12 feeb.
Cov kuab tshuaj sib tov-Npaj cov dej sib tov thiab tetrahydrofuran (70:30).
Cov txheej txheem kev npaj-Quantitatively yaj ib qho hnyav hnyav ntawm USP Ketorolac Tromethamine RS nyob rau hauv cov kuab tshuaj sib tov kom tau txais ib qho kev daws teeb meem uas paub txog qhov concentration ntawm 0.4 mg ib mL.[CEEB TOOM- Tiv thaiv cov tshuaj no los ntawm lub teeb.]
Kev tshuaj ntsuam xyuas-Hloov txog 20 mg ntawm Ketorolac Tromethamine, ntsuas kom raug, mus rau 50-mL ntim ntim ntim, dilute nrog hnyav sib tov rau ntim, thiab sib tov.[CEEB TOOM- Tiv thaiv cov tshuaj no los ntawm lub teeb.]
Kev daws teeb meem - Hauv 250-mL sib cais sib tov 100 mL dej, 100 mL ntawm dichloromethane, 30 mg ntawm USP Ketorolac Tromethamine RS, thiab 1 mL ntawm 1 N hydrochloric acid.Ntxig lub stopper, co, thiab cia cov khaubncaws sab nraud povtseg cais.Hloov cov txheej qis dichloromethane mus rau lub khob iav borosilicate iav, thiab muab pov tseg rau saum txheej.Tshem tawm cov tshuaj dichloromethane kom ncaj qha tshav ntuj rau 10 mus rau 15 feeb.Hloov 1.0 mL ntawm cov tshuaj mus rau ib lub vial, evaporate nyob rau hauv ib tug tam sim no ntawm huab cua los yog nyob rau hauv ib tug kwj ntawm nitrogen kom qhuav, ntxiv 1.0 mL ntawm Solvent sib tov, thiab swirl kom yaj.[CEEB TOOM-Qhov kev daws teeb meem no yuav muab khaws cia rau hauv tub yees thiab siv ntev npaum li cov chromatogram tau txais raws li qhia rau Cov Txheej Txheem yog tsim los txheeb xyuas qhov siab tshaj plaws vim yog ketorolac 1-keto analog thiab ketorolac 1-hydroxy analog, thiab rau kev ntsuas kev daws teeb meem. ntawm ketorolac 1-keto analog thiab ketorolac.]
Chromatographic system (saib Chromatography <621>) - Cov kua chromatograph yog nruab nrog 313-nm detector thiab 4.6-mm × 25-cm kem uas muaj 5-µm packing L7 thiab khaws cia ntawm qhov kub thiab txias li ntawm 40 °.Tus nqi ntws yog li 1.5 mL ib feeb.Chromatograph qhov kev daws teeb meem, thiab sau cov lus teb ncov raws li tau hais tseg rau Cov Txheej Txheem: lub sijhawm khaws cov txheeb ze yog kwv yees li 0.63 rau ketoroac 1-hydroxy analog, 0.89 rau ketorolac 1-keto analog, thiab 1.0 rau ketorolac;thiab kev daws teeb meem, R, nruab nrab ntawm ketorolac 1-keto analog thiab ketorolac tsis tsawg dua 1.5.Chromatograph tus qauv kev npaj, thiab sau cov lus teb ncov raws li qhia rau Cov Txheej Txheem: cov kab ke kev ua haujlwm tsis tsawg dua 5500 daim phiaj theoretical;thiab tus txheeb ze tus qauv sib txawv rau replicate txhaj tshuaj tsis ntau tshaj 1.5%.
Cov txheej txheem-Kev txhaj tshuaj sib npaug (kwv yees li 10 µL) ntawm Cov Txheej Txheem Kev Npaj thiab Kev Ntsuas Kev Ntsuas rau hauv cov chromatograph, sau cov chromatograms, thiab ntsuas cov lus teb rau cov peaks loj.Xam qhov ntau, hauv mg, ntawm C15H13NO3·C4H11NO3 hauv ib feem ntawm Ketorolac Tromethamine noj los ntawm cov mis:
50C (rU / rS)
nyob rau hauv uas C yog qhov concentration, nyob rau hauv mg ib mL, ntawm USP Ketorolac Tromethamine RS nyob rau hauv tus txheej txheem npaj;thiab rU thiab rS yog cov lus teb ntawm ketorolac ncov uas tau txais los ntawm Assay npaj thiab Standard npaj, feem.
