L-4-Nitrophenylalanine Methyl Ester HCl CAS 17193-40-7 H-Phe(4-NO2)-Ome ·HCl Kev Ntsuas > 98.5% (HPLC) Hoobkas
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom thiab cov chaw muag khoom ntawm L-4-Nitrophenylalanine Methyl Ester HCl (H-Phe(4-NO2)-OMe·HCl) (CAS: 17193-40-7) nrog cov khoom zoo.Ruifu Chemical muab ntau cov amino acids thiab derivatives.Peb tuaj yeem muab kev xa khoom thoob ntiaj teb, me me thiab ntau qhov ntau.Yog tias koj xav tau L-4-Nitrophenylalanine Methyl Ester HCl,Please contact: alvin@ruifuchem.com
| Tshuaj npe | L-4-Nitrophenylalanine Methyl Ester HCl |
| Synonyms | H-Phe(4-NO2)-Ome·HCl;Hp-Nitro-Phe-Ome · HCl;L-Phe(4-NO2)-Ome·HCl;p-Nitro-L-Phe-Ome · HCl;L-4-NO2-Phe-Ome · HCl;L-4-Nitrophenylalanine Methyl Ester Hydrochloride;4-Nitro-L-Phenylalanine Methyl Ester Hydrochloride;p-Nitrophenylalanine Methyl Ester Hydrochloride;Methyl 4-Nitro-L-Phenylalaninate Hydrochloride;(S)-(+)-4-Nitrophenylalanine Methyl Ester Hydrochloride |
| Tshuag xwm txheej | Hauv Tshuag, Muaj Peev Xwm Ntau Lawm 20 Tons ib Hlis |
| CAS Nr | 17193-40-7 ib |
| Molecular Formula | C10H12N2O4 · HCl |
| Molecular Luj | 260.67 Nws |
| Melting Point | 225.0 ~ 235.0 ℃ |
| Cia Temp. | Muab ntim rau hauv Qhuav, Khaws ntawm Chav Kub |
| COA & MSDS | Muaj |
| Kev faib tawm | Amino Acids thiab Derivatives |
| Hom | Ruifu Tshuaj |
| Risk Statements | 22-43-36 : kuv | Hazard Class | 6.1 |
| Cov lus hais txog kev nyab xeeb | 22-36/37-24/25 ib | Packing Group | III |
| RIDADR | 2811 ib | HS Code | 2922491990 ib |
| WGK Germany | 3 |
| Cov khoom | Kev soj ntsuam Standards | Cov txiaj ntsig |
| Kev piav qhia | Off-White to Pale Yellow Powder | Ua raws |
| Kev txheeb xyuas los ntawm HPLC | Lub sijhawm khaws cia ntawm lub ncov loj hauv chromatogram ntawm qhov kev npaj xeem sib raug rau qhov hauv chromatogram ntawm qhov system haum praparation raws li tau txais hauv chromatographic purity thiab impurities los ntawm HPLC | Ua raws |
| Kev sib hloov tshwj xeeb [α]20/D | 20.0 ~ 24.0° C = 1, MeOH | + 22.4 ° C |
| Melting Point | 225.0 ~ 235.0 ℃ | 227.0 ~ 230.0 ℃ |
| Poob rau ziab | <0.50% (ntawm 105 ℃ rau 3 teev) | 0.23% |
| Residue ntawm Ignition | <0.10% | 0.06% |
| Assay / Analysis Method | > 98.5% (los ntawm HPLC) | 98.75% |
| Cov ntsiab lus Enantiomer | <0.15% (los ntawm HPLC) | 0.09% |
| 4-Nitro-L-Phenylalanine | <1.50% (los ntawm HPLC) | 0.91% |
| Tag nrho cov impurities | <1.50% (los ntawm HPLC) | 1.25% |
| Xaus | Cov khoom no los ntawm Kev Tshawb Fawb Pom Zoo nrog Cov Txheej Txheem Enterprise | |
| Txee lub neej | 24 Lub Hlis Nyob rau hauv nws cov Original Ntim yog khaws cia kom raug | |
| Kev siv tseem ceeb | Pharmaceutical Intermediates;Zolmitriptan nruab nrab | |
Pob: Fluorinated Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, lossis raws li cov neeg siv khoom xav tau.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias, qhuav thiab cua tshuab kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Method of Analysis L-4-Nitrophenylalanine Methyl Ester HCl (H-Phe(4-NO2)-Ome·HCl) (CAS: 17193-40-7)
Nqe lus piav qhia: Muab li 2 g ntawm cov qauv rau hauv ib lub tais huv si thiab qhuav thiab ua raws li cov qauv.Tshaj Qhia: Qhia qhov kev soj ntsuam
Kev Qhia Txog Tus Kheej: Sib piv lub sijhawm khaws cia ntawm lub ncov loj hauv chromatogram ntawm qhov kev sim npaj nrog lub sijhawm khaws cia ntawm lub ncov loj hauv chromatogram ntawm qhov system haum raws li tau txais hauv chromatographic purity los ntawm HPLC.
Poob ntawm Kev Qhuav: Qhuav lub khob-stoppered, ntiav hnyav lub raj mis ntawm 105 ± 2 ℃ rau 30 feeb.Cia nws txias rau chav sov hauv lub desciccator.Ntsuas qhov hnyav ntawm lub raj mis nrog stopper thiab sau qhov hnyav (W1).Hloov li 1 mus rau 2g raug ntsuas kom muaj nuj nqis ntawm cov tshuaj ntsuam xyuas rau hauv lub raj mis hnyav.Los ntawm maj mam, sab xis tuav, faib cov qauv kuaj kom sib npaug raws li qhov ua tau mus txog qhov tob txog 5 hli.Ntsuas lub raj mis uas hnyav thiab sau qhov hnyav (W2).Muab lub raj mis ntim rau hauv qhov cub kom qhuav, tshem tawm lub stopper thiab tawm hauv lub chamber.Qhuav cov qauv kuaj ntawm 105 ± 2 ℃ rau 3 teev.Thaum qhib lub chamber, kaw lub raj mis kom sai, thiab cia nws tuaj rau hauv chav tsev kub hauv lub desiccator.Ntsuas qhov hnyav ntawm lub raj mis nrog stopper thiab recoed qhov hnyav (W3).Xam qhov feem pua poob ntawm kev ziab ntawm cov qauv los ntawm kev siv cov qauv hauv qab no:
Kev suav poob ntawm kev ziab (% w / w) = (W2-W3) ÷ (W2-W1) x 100
Cov ntsiab lus Enantiomer los ntawm HPLC:
Tshuaj & Reagents:
n-Hexane AR qib
Methanol HPLC qib
Isopropyl cawv HPLC qib
Diethylamine AR qib
Cov Qauv: L-4-Nitrophenylalanine Methyl Ester HCl tus qauv;L-4-Nitrophenylalanine Methyl Ester HCl enantiomer tus qauv
Mobile Phase: Npaj ib homogeneous sib tov ntawm n-Hexane, Isopropyl cawv, Methanol thiab Diethylamine (65:20:15:0.1 v/v/v/v)
Kev npaj dawb: Hloov 2.5ml ntawm Methanol nyob rau hauv 10-ml volumetric hwj, dilute mus rau ntim nrog mobile theem thiab sib tov.
Kev npaj kom haum rau qhov system:
Qhov hnyav kom raug thiab hloov mus txog 5 mg txhua ntawm L-4-Nitrophenylalanine Methyl Ester HCl tus qauv thiab L-4-Nitrophenylalanine Methyl Ester HCl enantiomer tus qauv hauv 10-ml ntim ntim, yaj hauv li 2.5ml ntawm methanol, dilute rau ntim nrog txawb. theem thiab sib tov.
Kev npaj xeem:
Ntsuas kom raug thiab hloov mus txog 5 mg ntawm cov qauv hauv 10-mol volumetric hwj, yaj hauv li 2.5ml ntawm methanol, dilute mus rau ntim nrog cov theem mobile thiab sib tov.
Instrumental Parameters:
Cov cuab yeej: HPLC nruab nrog lub tshuab nqus, twj tso kua mis, UV ntes thiab kaw
Kem: ChiralPak-IC (4.6mm x 250mm) 5 μ los yog sib npaug
Flow tus nqi: 1.0 ml / min
Lub wavelength: 260nm
Txhaj ntim: 10 μL
Kem coven temp.: 25 ℃
Lub sijhawm ua haujlwm: 20 feeb
Txheej txheem
Txhaj cov kev daws teeb meem raws li tau hais hauv cov kab hauv qab no.Sau cov chromatograms thiab paub meej cov qauv:
Nqe lus piav qhia txog Kev Txhaj Tshuaj Tus lej ntawm Kev Txhaum Cai
Kev Npaj Tsis Muaj 1 Tsis muaj kev cuam tshuam lub ncov yuav tsum tau pom thaum lub sijhawm khaws cia ntawm L-4-Nitrophenylalanine Methyl Ester HCl lossis enantiomer.
Kev npaj tsim nyog 1 Kev daws teeb meem ntawm L-4-Nitrophenylalanine Methyl Ester HCl thiab enantiomer ncov yuav tsum tsis pub tsawg dua 2.0
Kev npaj xeem 1 Siv cov chromatogram los txiav txim cov ntsiab lus enantiomer hauv cov qauv.
Lub Sijhawm Retention Relative:
L-4-Nitrophenylalanine Methyl Ester HCl 1.0
Enantiomer Txog 1.11
Lub sijhawm khaws cia ntawm L-4-Nitrophenylalanine Methyl Ester HCl yog li 9.8 feeb.
Kev suav: Hauv chromatogram tau los ntawm kev sim npaj, tsis quav ntsej tag nrho cov peaks xav tias L-4-Nitrophenylalanine Methyl Ester HCl thiab Enantiomer.Tshaj tawm cov ntsiab lus enantiomer hauv cov qauv los ntawm txoj kev normalization cheeb tsam.
Chromatogrpahic Purity thiab Impurities los ntawm HPLC:
Tshuaj & Reagents:
Diammonium phosphate AR qib
Phosphoric acid AR qib
Methanol HPLC qib
Purified Dej
Cov qauv
L-4-Nitrophenylalanine Methyl Ester HCl tus qauv
4-Nitro-L-Phenylalanine monohydrate tus qauv
Mobile Phase-A
Dissolve 6.6 g ntawm Diammonium phosphate nyob rau hauv 1000ml ntawm purified dej.Kho cov pH ntawm cov tshuaj no rau 6.0 nrog Phosphoric acid.Lim thiab degas.Ua ntej ntsuas pH ntawm kev daws, ntsuas pH ntsuas pH nrog tus qauv tsis haum tshuaj pH 4.01 THIAB 7.00.
Mobile Phase-B
Methanol HPLC qib
Kev Npaj Ua Haujlwm Zoo
Qhov hnyav kom raug thiab hloov mus txog 25 mg txhua ntawm L-4-Nitrophenylalanine Methyl Ester HCl tus qauv thiab 4-Nitro-L-Phenylalanine monohydrate tus qauv hauv 50-ml ntim ntim, yaj hauv thiab dilute rau ntim nrog methanol thiab sib tov.
Kev Npaj Xeem:
Ntsuas kom raug thiab hloov mus txog 25 mg qauv hauv 50-ml ntim ntim, yaj hauv thiab dilute rau ntim nrog methanol thiab sib tov.
Instrumental Parameters:
Cov cuab yeej: HPLC nruab nrog lub tshuab nqus, twj tso kua mis, UV ntes thiab kaw
Kem: XTerra RP-18 (4.6mm x 150mm) 5 μ los yog sib npaug
Flow tus nqi: 1.0 ml / min
Lub wavelength: 265nm
Txhaj ntim: 20 μL
Kem coven temp.: 25 ℃
Lub sijhawm ua haujlwm: 45 feeb
Gradient Program
Sijhawm (min) Txawb Phase-A % Txawb Phase-B %
0.0190 10
156040 ib
354060 ib
40 3565 ib
4190 10 ib
459010 ib
Txheej txheem:
Txhaj cov kev daws teeb meem raws li tau hais hauv cov kab hauv qab no.Sau cov chromatograms thiab paub meej cov qauv:
Kev Npaj Tsis Muaj 1 Tsis muaj kev cuam tshuam lub ncov yuav tsum tau pom thaum lub sijhawm khaws cia ntawm L-4-Nitrophenylalanine Methyl Ester HCl.
Kev npaj tsim nyog 1 Tailing yam rau L-4-Nitrophenylalanine Methyl Ester HCl ncov yuav tsum tsis pub tsawg tshaj 2.0
Kev npaj kuaj 1 Siv cov chromatogram kuaj los txiav txim siab chromatographic purity thiab impurities.
Lub Sijhawm Retention Relative:
L-4-Nitrophenylalanine Methyl Ester HCl 1.0 (lub sij hawm tuav txog 11.4 feeb)
4-Nitro-L-Phenylalanine Txog 0.4
Toluene Txog 2.3
Kev suav:
Hauv chromatogram tau los ntawm kev sim npaj, tom qab kho qhov khoob, tsis quav ntsej lub ncov vim toluene.Qhia txog chromatographic purity, 4-Nitro-L-Phenylalanine cov ntsiab lus thiab tag nrho cov impurities nyob rau hauv cov qauv los ntawm cheeb tsam normalization txoj kev.
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L-4-Nitrophenylalanine Methyl Ester HCl (H-Phe(4-NO2)-Ome·HCl) (CAS: 17193-40-7) yog ib qho nruab nrab hauv kev sib xyaw ntawm ntau yam tshuaj sib xyaw.L-4-Nitrophenylalanine Methyl Ester HCl tuaj yeem siv rau kev npaj ntawm Matijing-Su derivatives ua cov tshuaj tiv thaiv HBV muaj zog.L-4-Nitrophenylalanine Methyl Ester HCl tuaj yeem siv los ua cov tshuaj nruab nrab ntawm Zolmitriptan (CAS: 139264-17-8).Zolmitriptan yog ib qho kev xaiv serotonin receptor agonist ntawm 1B thiab 1D subtypes.Nws yog tsuas yog siv rau kev kho mob ntawm migraine tawm tsam nrog lossis tsis muaj aura thiab mob taub hau.Zolmitriptan siv cov txiaj ntsig los ntawm kev khi rau tib neeg 5-HT1Band 5-HT1Dreceptors, ua rau cov hlab ntsha cranial constriction thiab tso tawm ntawm kev hnov mob neuropeptides los ntawm cov hlab ntsha xaus hauv trigeminal system.
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