LCZ696 Intermediate CAS 1426129-50-1 Purity ≥98.0% (HPLC) thiab ≥99.0% Hoobkas High Purity
Kev Lag Luam Kev Lag Luam LCZ696 (CAS: 936623-90-4) Cov Neeg Nruab Nrab:
(R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1
(R,E)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S)-ethyl 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (hemicalcium ntsev) CAS: 1369773-39-6
UA-377;Sacubitril CAS: 149709-62-6
LCZ696;Entresto;Sacubitril sib tov nrog Valsartan CAS: 936623-90-4
| Tshuaj npe | (R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate |
| Synonyms | LCZ696 Intermediate |
| CAS Nr | 1426129-50-1 |
| CAT Number | Qauv: RF-PI169 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale nce mus txog pua pua ntawm Kilograms |
| Molecular Formula | C20H25NO3 |
| Molecular Luj | 327.42 ib |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Dawb rau Off-White Powder |
| Purity / Analysis Method | ≥98.0% (HPLC) |
| Enantiomeric Tshaj | Tus nqi: ≥99.0% |
| Moisture (KF) | ≤ 1.0% |
| Yam khoom muaj feem A | ≤1.0% (RRT=0.5) A=(R)-3-([1,1'-biphenyl]-4-yl)-2-aminopropan-1-ol |
| Yam khoom muaj feem B | ≤1.0% (RRT = 0.85) B = Triphenylphosphine oxide |
| Lwm Yam | ≤ 1.0% |
| Tag nrho cov impurities | ≤ 2.0% |
| Test Standard | Enterprise Standard |
| Kev siv | Intermediate ntawm LCZ696 (CAS: 936623-90-4) hauv kev kho HFrEF |
Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.
Chaw tsim tshuaj paus nrog High Purity thiab ruaj khov zoo
Kev Lag Luam Kev Lag Luam LCZ696 (CAS: 936623-90-4) Cov Neeg Nruab Nrab:
(R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1
(R,E)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S)-ethyl 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (hemicalcium ntsev) CAS: 1369773-39-6
UA-377;Sacubitril CAS: 149709-62-6
LCZ696;Entresto;Sacubitril sib tov nrog Valsartan CAS: 936623-90-4
LCZ696 yog ib qho kev sim tshuaj uas tsim los ntawm Novartis Pharmaceutical ntawm Tebchaws Meskas rau kev kho cov neeg mob plawv tsis ua hauj lwm nrog txo Ejection Fraction (HFrEF).Lub plawv tsis ua hauj lwm yog ib yam kab mob uas yuav ua rau lub neej.Tus neeg mob lub plawv tsis tuaj yeem tso ntshav txaus los muab lub cev, thiab tshwm sim cov tsos mob ntawm kev ua tsis taus pa, qaug zog thiab ua kua dej maj mam, tom qab ntawd maj mam nce, cuam tshuam rau lub neej zoo.LCZ696 tuaj yeem txhim kho lub cev tiv thaiv lub plawv tsis ua haujlwm, nrog rau nce qib ntawm natriuretic peptides thiab lwm yam endogenous vasoactive peptides, thiab inhibit renin-angiotensin-aldosterone system (RAAS).LCZ696 tau ua ke nrog Novartis's Hypertension Medication (Divan, generic lub npe: valsartan) thiab cov tshuaj sim AHU-377.AHU377 thaiv cov txheej txheem ntawm ob lub peptides lub luag haujlwm rau txo cov ntshav siab.Diovan txhim kho vasodilatation thiab txhawb lub cev kom tshem tawm sodium thiab dej.
