Lesinurad (RDEA 594) CAS 878672-00-5 Purity > 99.5% (HPLC) Assay 98.0 ~ 102.0%
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom ntawm Lesinurad (RDEA 594) (CAS: 878672-00-5) nrog cov khoom zoo.Ruifu Chemical tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, kev pabcuam zoo heev, me me thiab ntau ntau muaj.Yuav Lesinurad thiab Intermediates,Please contact: alvin@ruifuchem.com
| Tshuaj npe | Lesinurad |
| Synonyms | 2-[[5-Bromo-4-(4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-Triazol-3-yl]thio]acetic acid;2-[[5-Bromo-4-(4-Cyclopropyl-1-Naphthalenyl)-4H-1,2,4-Triazol-3-yl]thio]-Acetic Acid;RDEA 594;RDEA-594;RDEA594;Zurampic |
| Tshuag xwm txheej | Hauv Tshuag, Kev Lag Luam Ntau Lawm |
| CAS Nr | 878672-00-5 |
| Molecular Formula | C17H14BrN3O2S |
| Molecular Luj | 404.28 g / mol |
| Melting Point | ≥171 ℃ (txog.) |
| Qhov ntom | 1.72 ± 0.10g / cm3 |
| COA & MSDS | Muaj |
| Keeb kwm | Shanghai, Suav |
| Hom | Ruifu Tshuaj |
| Cov khoom | Kev soj ntsuam Standards | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb rau Off-White Powder | Off-White hmoov |
| Kev txheeb xyuas | Lub sijhawm khaws cia ntawm qhov tseem ceeb ntawm cov qauv kev daws teeb meem sib haum rau cov qauv siv | Ua raws |
| Dej los ntawm Karl Fischer | <0.50% | 0.14% |
| Residue ntawm Ignition | <0.10% | 0.03% |
| Heavy Metals (Pb) | ≤10ppm | <10ppm |
| Yam khoom (HPLC) | ||
| Qhov loj tshaj ib leeg impurity | <0.20% | 0.07% |
| Tag nrho cov impurities | <1.00% | 0.24% |
| Purity / Analysis Method | > 99.5% (HPLC cheeb tsam) | 99.76% |
| Assay | 98.0 ~ 102.0% | 99.6% |
| Infrared Spectrum | Raws li tus qauv | Ua raws |
| NMR Spectrum | Raws li tus qauv | Ua raws |
| Xaus | Cov khoom tau raug kuaj thiab ua raws li cov lus qhia tshwj xeeb | |
Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws lub thawv kaw kom nruj thiab khaws cia rau hauv qhov chaw txias, qhuav (2 ~ 8 ℃) thiab lub tsev tso cua txias kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
Lesinurad (RDEA 594) (CAS: 878672-00-5) tau pom zoo los ntawm US Food and Drug Administration (FDA) thaum Lub Kaum Ob Hlis 22, 2015, thiab tom qab ntawd pom zoo los ntawm European Medicines Agency (EMA) thaum Lub Ob Hlis 18, 2016. Qhov sib xyaw ua ke tau tsim ua ntej los ntawm Ardea.AstraZeneca tau txais lub tuam txhab hauv xyoo 2012, uas nyob rau hauv lem tau txais cov khoom.Cov tshuaj lub npe lag luam yog Zurampic® hauv Tebchaws Meskas thiab European Union.Lesinurad yog lub ntiaj teb thawj zaug pom zoo urate reuptake transporter (URAT1) inhibitor, ua ke nrog xanthine oxidase inhibitors los kho hyperuricemia ntsig txog gout.
Lesinurad, lub npe lag luam Zurampic.Lesinurad ua ke nrog xanthine oxidase inhibitor (XOI) rau hyperuricemic gout syndrome.Nws cov txheej txheem ntawm kev ua haujlwm yog pab lub raum tso tawm uric acid, thiab nws ua haujlwm los ntawm inhibiting kev ua haujlwm ntawm cov neeg thauj khoom koom nrog hauv uric acid reabsorption hauv ob lub raum.
Lesinurad inhibits uric acid thauj kev ua si (IC50 = 3.36 μM) ntawm hURAT1 (tib neeg URAT1), uas yog ntau tshaj 20 npaug ntawm inhibitory nyhuv ntawm rURAT1 (rat URAT1) (IC50 = 74.84 μM).Lesinurad inhibit hURAT1 los ntawm kev sib cuam tshuam ntawm cov amino acid residue Phe365.
