Lopinavir CAS 192725-17-0 API Anti-HIV HIV Protease Inhibitor COVID-19 High Purity Featured Duab

Lopinavir CAS 192725-17-0 API Anti-HIV HIV Protease Inhibitor COVID-19 Siab Purity

Lus piav qhia luv luv:

Lub npe tshuaj: Lopinavir

CAS: 192725-17-0 Nr

Tsos: Dawb rau Tawm Dawb Hmoov

Kev ntsuam xyuas (HPLC): 98.0% ~ 102.0%

Selective Peptidomimetic HIV-1 Protease Inhibitor

API High Quality, Commercial Production

Inquiry: alvin@ruifuchem.com

Xa email rau peb

Product Detail

Yam khoom

Khoom cim npe

Nqe lus piav qhia:

Chaw tsim tshuaj paus Supply nrog High Purity thiab ruaj khov zoo
Lub npe tshuaj: Lopinavir
CAS: 192725-17-0 Nr
Tus muaj peev xwm, xaiv Peptidomimetic HIV-1 Protease Inhibitor
Cov khoom lag luam tshawb fawb txog COVID-19
API High Quality, Commercial Production

Chemical Properties:

Tshuaj npe	Lopinavir
Synonyms	LPV;ABT-378;Kaletra
CAS Nr	192725-17-0
CAT Number	RF-API 73
Tshuag xwm txheej	Nyob rau hauv Tshuag, ntau lawm Scale nce mus txog pua pua ntawm Kilograms
Molecular Formula	C37H48N4O5
Molecular Luj	628.81 ib
Kev Cia Lub Sij Hawm Ntev	Khaws lub sijhawm ntev ntawm 2-8 ℃
Hom	Ruifu Tshuaj

Specifications:

Yam khoom	Specifications
Qhov tshwm sim	Dawb rau Off-White Powder
Solubility	Dawb Soluble hauv Methanol thiab hauv Ethanol, Soluble hauv 2-Propanol
Identification IR	Infrared absorption spectrum ntawm cov qauv xeem yog concordant nrog spectrum ntawm kev siv tus qauv
Kev txheeb xyuas HPLC	Lub sijhawm khaws cia ntawm cov qauv xeem sib raug raws li tus qauv siv
Cov ntsiab lus dej (los ntawm KF)	≤ 4.0%
Specific Optical Rotation	-22.0 ° rau -26.0 °
Residue ntawm Ignition	≤ 0.20%
Hnyav Hlau	≤ 20ppm
Melting Point	124.0 txog 127.0 ℃
Sulfated tshauv	≤ 0.20%
Residual Solvent (Ethanol)	≤0.50%
Yam khoom muaj feem	(HPLC, cheeb tsam%)
impurity 1
Qhov tsis zoo B (RRT = 0.07)	≤ 0.20%
Impurity I (RRT = 1.10)	≤ 0.20%
Lwm yam impurity	≤0.10%
impurity 2	Lwm Tus Neeg Tsis Pom Zoo ≤0.10%
Tag nrho cov impurities los ntawm txheej txheem 1 thiab 2	≤ 0.70%
Tag nrho cov impurities	≤ 1.0%
Assay (los ntawm HPLC)	98.0% ~ 102.0%.
Test Standard	Enterprise Standard
Kev siv	Selective Peptidomimetic HIV-1 Protease Inhibitor, KEVID-19 Cov Khoom Siv Tshawb Fawb

Pob & Cia:

Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.

Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.

Qhov zoo:

FAQ:

Daim ntawv thov:

Lopinavir (ABT-378) yog lub zog muaj zog, xaiv peptidomimetic inhibitor ntawm HIV-1 protease, nrog Kis ntawm 1.3 txog 3.6 pM rau cov tsiaj qus thiab mutant HIV protease.Lopinavir ua los ntawm kev ntes kev loj hlob ntawm HIV-1 yog li thaiv nws cov kab mob.Lopinavir is also a SARS-CoV 3CLpro inhibitor with IC50 of 14.2 μM.Lopinavir yog ib qho tshuaj tiv thaiv kab mob ntawm protease inhibitor chav kawm.Inhibition ntawm HIV-1 protease tiv thaiv cleavage ntawm tus kab mob polyprotein precursor thiab ua rau tso tawm ntawm tsis paub tab, tsis muaj kab mob virions.Ib feem ntawm kev kho ua ke los kho HIV/AIDS.Lopinavir, tus thib rau HIV protease inhibitor hauv chav kawm "navir", tau pib ua ke nrog ritonavir, lwm tus HIV protease inhibitor twb tau ua lag luam (Abbott, 1996);Cov txheej txheem qub no tau qhia ua Kaletra rau kev siv ua ke nrog nucleoside lossis non-nucleoside thim rov qab transcriptase inhibitors rau kev kho mob AIDS rau cov neeg laus thiab menyuam yaus.Lopinavir yog ib qho peptidomimetic compound nrog cov qauv txheej txheem zoo ib yam li ritonavir, ntawm cov pab pawg davhlau ya nyob twg, tshwj xeeb yog hloov pauv valine, tau qhia los ntawm cov txheej txheem peptide coupling.Lopinavir yog tus muaj zog sib tw inhibitor ntawm HIV-I protease uas muaj peev xwm tiv thaiv ritonavir-resistant mutations.Hauv ntau hom tsiaj, kev tshawb fawb pharmacokinetic nrog lub koom haum lopinavirlritonavir tau pom tias cov khoom me me ntawm lopinavir tau txhim kho tau zoo nyob rau hauv muaj ritonavir, hais txog Cmax thiab lub sijhawm ua haujlwm.