Losartan Potassium CAS 124750-99-8 API Hoobkas Antihypertensive High Purity
Muab Losartan Potassium thiab lwm yam Intermediates nrog Zoo Siab
Losartan Potassium CAS 124750-99-8
2-Butyl-4-Chloro-5-Formylimidazole (BCFI) CAS 83857-96-9
| Tshuaj npe | Losartan Potassium |
| Synonyms | pom 753;Cozaar;2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]imidazole-5-methanol Potassium ntsev |
| CAS Nr | 124750-99-8 |
| CAT Number | RF-API 98 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
| Molecular Formula | C22H22ClKN6O |
| Molecular Luj | 461.01 Nws |
| Melting Point | 263.0 ~ 265.0 ℃ |
| Solubility | Dawb soluble hauv dej thiab hauv Methanol, me ntsis soluble hauv acetonitrile. |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Dawb los yog Yuav luag Dawb Crystalline Hmoov |
| Kev Taw Qhia A | Infrared Absorption: Yuav tsum Zoo ib yam li Cov Qauv Siv |
| Kev Qhia B | Ultraviolet absorption: Yuav tsum Zoo ib yam li Cov Qauv Siv |
| Test rau Potassium | Yuav tsum muaj qhov zoo |
| Cov ntsiab lus dej (KF) | ≤0.50% |
| Hnyav Hlau | ≤10ppm |
| Yam khoom (HPLC) | |
| Txhua tus neeg impurity | ≤ 0.20% |
| Tag nrho cov impurities | ≤0.50% |
| Residual Solvents (GC) | |
| Cyclhexane | ≤0.10% |
| Isopropyl cawv | ≤ 0.20% |
| Assay/Analysis Method | 98.5 ~ 101.0% (HPLC, xam raws li anhydrous, hnyav-dawb hauv paus) |
| N-Nitrosodimethylamine | ≤ 0.177ppm (NDEA) |
| N-Nitrosodimethylamine | ≤0.640ppm (NDMS) |
| Particle Loj | 90% Tsawg dua 38 Microns |
| Txee lub neej | 24 Lub Hlis |
| Test Standard | Enterprise Standard |
| Kev siv | API, Angiotensin II Receptor Antagonist Antihypertensive |
Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.
Losartan Potassium yog thawj lub zog thiab xaiv tsis yog peptide angiotensin II receptor type 1 (AT1) antagonist qhia rau lub lag luam raws li ib hnub ib hnub ntawm qhov ncauj antihypertensive.Qhov concentration uas inhibits 50% ntawm kev khi ntawm angiotensin II (IC50) yog 20 nM.Losartan (40 μM) cuam tshuam rau ISC tab sis tiv thaiv cov nyhuv ntawm ANGII ntawm ISC.Losartan txo qis Ang II-mediated cell proliferation hauv endometrial cancer hlwb.Kev sib xyaw ua ke ntawm losartan thiab anti-miR-155 muaj cov nyhuv antiproliferative ntau dua piv rau txhua yam tshuaj ib leeg.Nws yog metabolized los tsim 5-carboxylic acid metabolite (EXP3174) thiab tau tshaj tawm kom txo cov ntshav siab.Tam sim no nws tab tom tshawb nrhiav los ua qhov kev kho mob zoo rau COVID-19 rau nws lub peev xwm los txo qis lossis txo qis cov tsos mob ntawm COVID-19.
1. Rau kev kho mob ntshav siab tseem ceeb, nws tuaj yeem siv ib leeg lossis ua ke nrog lwm cov tshuaj tiv thaiv hypertensive (xws li diuretics).2. Rau kev kho mob plawv tsis ua hauj lwm, nws tuaj yeem siv ib leeg lossis ua ke nrog cov tshuaj cardiotonic lossis diuretic Chemicalbook.3. Tiv thaiv kev mob stroke hauv cov neeg mob ntshav siab thiab sab laug ventricular hypertrophy.4. Nws yog siv los ua kom qeeb kev loj hlob ntawm nephropathy nyob rau hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus cuam tshuam nrog nephropathy thiab kub siab.
