Methyl 2-Oxoindoline-6-Carboxylate CAS 14192-26-8 Purity > 99.0% (HPLC) Nintedanib Esylate Intermediate Factory
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom thiab cov chaw muag khoom ntawm Methyl 2-Oxoindoline-6-Carboxylate (CAS: 14192-26-8) nrog cov khoom zoo, kev lag luam ntau lawm.
Tshuaj npe | Methyl 2-Oxoindoline-6-Carboxylate |
Synonyms | 2-Oxoindoline-6-Carboxylic Acid Methyl Ester;Methyl Oxindole-6-Carboxylate |
CAS Nr | 14192-26-8 ib |
CAT Number | Qauv TSIS MUAJ: RF-PI1524 |
Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
Molecular Formula | C10H9NO3 |
Molecular Luj | 191.19 Nws |
Melting Point | 184.0 ~ 190.0 ℃ |
Hom | Ruifu Tshuaj |
Yam khoom | Specifications |
Qhov tshwm sim | Lub teeb daj rau xim av hmoov |
1 H NMR Spectrum | Raws li tus qauv |
Purity / Analysis Method | > 99.0% (HPLC) |
Poob rau ziab | <1.00% |
Tag nrho cov impurities | <1.00% |
Test Standard | Enterprise Standard |
Kev siv | Nintedanib Esylate (CAS: 656247-18-6) |
Methyl 2-Oxoindoline-6-Carboxylate (CAS: 14192-26-8) Synthetic Route
Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo.
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Methyl 2-Oxoindoline-6-Carboxylate (CAS: 14192-26-8) yog ib qho nruab nrab siv los npaj Nintedanib Esylate (CAS: 656247-18-6).Nintedanib Esylate yog ib qho muaj zog, qhov ncauj triple angiokinase inhibitor tsim los ntawm Boehringer Ingelheim uas lub hom phiaj proangiogenic thiab pro-fibrotic txoj kev kho los ntawm vascular endothelial kev loj hlob receptor, fibroblast kev loj hlob receptor thiab plateletderived kev loj hlob receptor tsev neeg, nrog rau Src thiab Flt-3. kinases.Nintedanib Esylate tau txais kev pom zoo rau kev kho mob ntawm idiopathic pulmonary fibrosis (IPF), ib qho mob uas lub ntsws ua kom muaj caws pliav nyob rau lub sijhawm, los ntawm US FDA thaum Lub Kaum Hli 2014 thiab los ntawm EMA thaum Lub Ib Hlis 2015. FDA tau tso cai nintedanib esylate nrawm nrawm. , kev tshuaj xyuas qhov tseem ceeb, cov khoom lag luam me nyuam ntsuag, thiab kev ua tiav cov npe.Nws kuj tau txais kev pom zoo los ntawm EMA thaum lub Kaum Ib Hlis 2014 rau kev kho mob ntawm cov qog nqaij hlav tsis me me hauv lub ntsws ua ke nrog docetaxel tom qab thawj kab tshuaj kho mob.
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