N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1 Purity > 99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

Lus piav qhia luv luv:

Lub npe tshuaj: N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine

CAS: 162012-67-1 Nr

Purity:> 99.0% (HPLC)

Cov tsos mob: Lub teeb daj rau daj hmoov

Intermediate of Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

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Product Detail

Yam khoom

Khoom cim npe

Nqe lus piav qhia:

Ruifu Chemical Supply Intermediates ntawm Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
Tom ntej: Dimethylamino Acetaldehyde Diethyl Acetal CAS 3616-56-6
Tom ntej: Trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-ib CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS Nr .: 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS Nr .: 314771-88-5

Chemical Properties:

Tshuaj npe	N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine
Synonyms	N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitro-4-Quinazolinamine;(3-Chloro-4-Fluorophenyl) (7-Fluoro-6-Nitroquinazolin-4-yl) amine;4-(3-Chloro-4-Fluoroanilino)-7-Fluoro-6-Nitroquinazoline;Afatinib Intermediate A
CAS Nr	162012-67-1
CAT Number	Tus Qauv Zauv: RF-PI2026
Tshuag xwm txheej	Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons
Molecular Formula	C14H7ClF2N4O2
Molecular Luj	336.68 ib
rhiab heev	Cua Sensitive, Thaum tshav kub kub Sensitive
Melting Point	242.0 ~ 244.0 ℃
Boiling Point	489 ℃
Qhov ntom	1.616 ib
Hom	Ruifu Tshuaj

Specifications:

Yam khoom	Specifications
Qhov tshwm sim	Lub teeb daj rau daj hmoov
Purity / Analysis Method	> 99.0% (HPLC)
Poob rau ziab	<0.50%
Residue ntawm Ignition	<0.20%
Yam khoom muaj feem
Tus kheej impurity	<0.50%
Tag nrho cov impurities	<1.00%
Hnyav Hlau	≤ 20ppm
Infrared Spectrum	Raws li tus qauv
Proton NMR Spectrum	Raws li tus qauv
Test Standard	Enterprise Standard
Kev siv	Intermediate of Afatinib Dimaleate (CAS: 850140-73-7)

Pob & Cia:

Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj

Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo

Qhov zoo:

FAQ:

Daim ntawv thov:

N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine (CAS: 162012-67-1) yog ib qho nruab nrab hauv kev sib xyaw ntawm Afatinib Dimaleate (CAS: 850140-73-7) .Afatinib Dimaleate yog ntsev daim ntawv ntawm Afatinib.Afatinib yog ib tiam thib ob, kev tswj hwm qhov ncauj, irreversible inhibitor ntawm ErbB tsev neeg ntawm tyrosine kinases.Mechanism of ActionAfatinib downregulates ErbB signaling by covalently binding to the kinase domains of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER) 2 thiab HER4, ua rau irreversible inhibition ntawm tyrosine kinase autophosphorylation;Nws kuj inhibits transphosphorylation ntawm HER3.Afatinib tau pom zoo raws li kev kho mob monotherapy rau kev kho mob ntawm EGFR tyrosine kinase inhibitor (TKI)-cov neeg laus uas tsis paub qab hau nrog cov neeg laus hauv zos lossis DefinitionChEBI: Cov ntsev ntsev tau los ntawm kev sib txuas afatinib nrog ob lub molar sib npaug ntawm cov txiv roj roj.Siv rau thawj kab kev kho mob ntawm cov neeg mob uas muaj metastatic uas tsis yog-me me ntawm lub ntsws cancer.