N-Acetyl-L-Cysteine CAS 616-91-1 (Ac-Cys-OH; NAC) Assay 98.5 ~ 101.0% Hoobkas High Quality
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom thiab cov chaw muag khoom ntawm N-Acetyl-L-Cysteine (Ac-Cys-OH; NAC) (CAS: 616-91-1) nrog cov khoom zoo.Ruifu Chemical muab ntau cov amino acids thiab derivatives.Vim peb cov khoom zoo heev, tus nqi tsim nyog, peb tau txais lub koob npe zoo nrog rau kev ntseeg siab los ntawm peb cov neeg siv khoom hauv tsev thiab txawv teb chaws.Peb tuaj yeem muab COA, xa khoom thoob ntiaj teb, me me thiab ntau ntau.Yog tias koj txaus siab rau N-Acetyl-L-Cysteine,Please contact: alvin@ruifuchem.com
| Tshuaj npe | N-Acetyl-L-Cysteine |
| Synonyms | Ac-Cys-OH;Acetylcysteine ;NAC;LNAC;N-Acetylcysteine;N-Acetyl-3-Mercaptoalanine;Acetyl-Laevo-Cysteine |
| Tshuag xwm txheej | Hauv Tshuag, Muaj Peev Xwm Ntau Lawm 50 Tons ib Hlis |
| CAS Nr | 616-91-1 |
| Molecular Formula | C5H9NO3S |
| Molecular Luj | 163.19 Nws |
| Melting Point | 106.0 ~ 108.0 ℃ (lit.) |
| rhiab heev | Huab cua Sensitive |
| Dej Solubility | Soluble hauv dej, Yuav luag Transparency |
| Solubility | Soluble hauv Ethanol, Methanol, Cawv.Xyaum Insoluble hauv Ether |
| Cia Temp. | Muab ntim rau hauv Qhuav, Khaws ntawm Chav Kub |
| COA & MSDS | Muaj |
| Kev faib tawm | Amino Acids thiab Derivatives |
| Hom | Ruifu Tshuaj |
| Risk Statements | 36/37/38 - Kab mob rau qhov muag, ua pa thiab tawv nqaij. |
| Cov lus hais txog kev nyab xeeb | S22 - Tsis txhob nqus plua plav.S24/25 - Tsis txhob sib cuag nrog daim tawv nqaij thiab qhov muag. |
| WGK Germany | 3 |
| RTECS | HA1660000 |
| F | 10-23 |
| TSCA | Yog lawm |
| HS Code | 2922491990 ib |
| Cov khoom | Kev soj ntsuam Standards | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb Crystals lossis Crystalline Hmoov;Muaj zog acid saj | Ua raws |
| Kev txheeb xyuas | Infrared Absorption Spectrum yog tsim | Ua raws |
| Kev sib hloov tshwj xeeb [α]20/D | +21.3° to +27.0° (C = 5 in Phosphate Buffered Saline) | + 23.5 ° C |
| State of Solution (Kev xa tawm) | Ntshiab thiab tsis muaj xim ≥98.0% | 99.0% |
| Chloride (Cl) | ≤ 0.040% | <0.040% |
| Sulfate (SO4) | ≤ 0.030% | <0.030% |
| Ammonium (NH4) | ≤ 0.020% | <0.020% |
| Hlau (Fe) | ≤ 20ppm | <20 ppm |
| Heavy Metals (Pb) | ≤10ppm | <10ppm |
| Zinc (Zn) | ≤10ppm | <10ppm |
| Arsenic (As2O3) | ≤ 1.0ppm | <1.0ppm |
| Yam khoom muaj feem | (HPLC Method) | |
| L-Cystine | ≤0.50% | Ua raws |
| L-cysteine | ≤0.50% | Ua raws |
| N, N'-Diacetyl-L-Cystine | ≤0.50% | Ua raws |
| N, S-Diacetyl-L-Cysteine | ≤0.50% | Ua raws |
| Ib leeg Impurity | ≤0.50% | Ua raws |
| Tag nrho cov impurities | ≤0.50% | Ua raws |
| Poob rau ziab | ≤0.50% | 0.20% |
| Residue ntawm Ignition (Sulfated) | ≤ 0.20% | 0.05% |
| Assay | 98.5 mus rau 101.0% (nyob rau hauv Qhuav Basis) | 99.90% |
| Tus nqi pH | 2.0 txog 2.8 (1.0g hauv 100ml ntawm H2O) | 2.5 |
| Biochemical Toxicity | Hla | Hla |
| Volatile Organic Khoom | Hla | Hla |
| Endonuclease Detection | ≤0.1 EU / g | <0.1 EU/g |
| Xaus | Cov khoom no los ntawm Kev Tshawb Fawb Pom Zoo nrog Tus Qauv ntawm AJI97 | |
| Kev siv tseem ceeb | Amino Acids;Khoom noj khoom haus additives;Pharmaceutical Intermediates | |
Pob: Fluorinated Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, lossis raws li cov neeg siv khoom xav tau.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias, qhuav thiab cua tshuab kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
N-Acetyl-L-Cysteine (Ac-Cys-OH; NAC) (CAS: 616-91-1) AJI97 Test Method
N-Acetyl-L-Cysteine, thaum qhuav, muaj tsis tsawg tshaj li 98.5 feem pua thiab tsis ntau tshaj 101.0 feem pua ntawm N-Acetyl-L-Cysteine (C5H9NO3S).
Nqe lus piav qhia: Dawb crystals los yog crystalline hmoov, muaj zog acid saj.
Dawb soluble hauv dej, soluble hauv ethanol, xyaum insoluble hauv ether.
Solubility (H2O, g / 100g): 17 (20 ℃), 80 (40 ℃), 260 (60 ℃)
Kev txheeb xyuas: Sib piv cov infrared absorption spectrum ntawm cov qauv nrog cov qauv ntawm cov txheej txheem potassium bromide disc.
Kev sib hloov tshwj xeeb [α] 20 / D: Cov qauv qhuav, C = 8, phosphate buffer tov
State of Solution (Transmittance): 0.5g hauv 10ml ntawm H2O, spectrophotometer, 430nm, 10mm cell thickness.
Heavy Metals (Pb): 2.0g, (1), ref: 2.0ml ntawm Pb Std.(0.01 mg/ml)
Zinc (Zn): Atomic absorption method
Yam Khoom Siv: HPLC txoj kev
Poob rau ziab: Hauv lub tshuab nqus tsev, ntawm 70 ℃ rau 4 teev
Residue ntawm Ignition (Sulfated): AJI Test 13
Assay: Cov qauv qhuav, 200mg, 0.05mol / L I2 1ml = 16.320mg C5H9NO3S
pH: 1.0g hauv 100ml H2O
Pom zoo cia txwv thiab mob: khaws cia ntim ntim ntawm qhov kub thiab txias (1 xyoos).
N-Acetyl-L-Cysteine (Ac-Cys-OH; NAC) (CAS: 616-91-1) USP35 Test Method
DEFINITION
Acetylcysteine muaj NLT 98.0% thiab NMT 102.0% ntawm L-threonine (C5H9NO3S), suav ntawm lub hauv paus qhuav.
IDENTIFICATION
A. INFRARED ABSORPTION <197K>
QHIA
txheej txheem
Mobile theem: 6.8 g / L ntawm monobasic potassium phosphate.Kho nrog phosphoric acid rau pH ntawm 3.0.
Sodium metabisulfite daws: 0.5 mg / mL ntawm sodium metabisulfite hauv dej, npaj tshiab
Cov txheej txheem sab hauv: 5 mg / mL ntawm USP L-Phenylalanine RS hauv Sodium metabisulfite kua
Standard Tshuag tov: 10 mg / mL ntawm USP Acetylcysteine RS hauv Sodium metabisulfite kua
Standard tov: 0.5 mg / mL ntawm USP Acetylcysteine RS thiab 0.25 mg / mL ntawm USP L-Phenylalanine RS nyob rau hauv Sodium metabisulfite tov los ntawm Standard Tshuag tov thiab Internal standard tov
Piv txwv cov tshuaj: 10 mg / mL ntawm Acetylcysteine nyob rau hauv Sodium metabisulfite tov
Cov qauv tshuaj: 0.5 mg / mL ntawm Acetylcysteine thiab 0.25mg / mL ntawm USP L-Phenylalanine RS hauv Sodium metabisulfite tov los ntawm Cov Qauv Tshuag thiab Cov Qauv Txheej Txheem
Chromatographic system
(Saib Chromatography <621>, System Suitability.)
Qauv: LC
Detector: UV 214 nm
Kem: 3.9-mm × 30-cm;ntim L1
Tus nqi ntws: 1.5 mL / min
Kev txhaj tshuaj loj: 5 µL
Qhov system haum
[CEEB TOOM-Lub sij hawm tuav tus txheeb ze rau acetylcysteine thiab L-phenylalanine yog hais txog 0.5 thiab 1.0, feem.]
Suitability xav tau
Kev daws teeb meem: NLT 6 ntawm acetylcysteine thiab L-phenylalanine
Tus txheeb ze tus qauv sib txawv: NMT 2.0%
Kev tsom xam
Qauv: Cov qauv kev daws teeb meem thiab cov qauv kev daws teeb meem
Xam cov feem pua ntawm acetylcysteine (C5H9NO3S) hauv feem ntawm Acetylcysteine ntaus:
Result = (RU/RS) × (CS/CU) × 100
RU = peak teb ratio ntawm acetylcysteine rau L-phenylalanine los ntawm cov qauv tshuaj
RS = peak teb piv ntawm acetylcysteine rau L-phenylalanine los ntawm Standard tov
CS = concentration ntawm USP Acetylcysteine RS nyob rau hauv Standard tov (mg / mL)
CU = concentration ntawm acetylcysteine hauv cov qauv tshuaj (mg / mL)
Kev lees paub: 98.0% -102.0% ntawm lub hauv paus qhuav
IMPURITIES
RESIDUE ON IGNITION <281>: NMT 0.5%
HEAVY METALS, Method II <231>
[CAUTION-Kev saib xyuas kev noj qab haus huv vim tias qhov tawg tuaj yeem tshwm sim.]
Kev Ntsuam Xyuas: Hauv ib qho kev poob qis, ntub cov qauv nrog 2 mL ntawm nitric acid, thiab ua raws li tau hais tseg rau Kev Xeem Xeem.
Kev lees txais: NMT 10 ppm
TSEEM CEEB
OPTICAL ROTATION, Kev sib hloov tshwj xeeb <781S>
Tsis Siv Neeg: Sib tov 29.5 mL ntawm 1 N sodium hydroxide, 50 mL ntawm 1 M monobasic potassium phosphate, thiab dej txaus los ua 100 mL.Kho kom haum rau pH ntawm 7.0 ± 0.1 los ntawm kev ntxiv cov tshuaj ntxiv, raws li qhov tsim nyog.
Cov qauv tshuaj: Hauv 25-mL ntim ntim ntim, sib tov 1.25 g nrog 1 mL ntawm edetate disodium tov (1 hauv 100), ntxiv 7.5mL ntawm sodium hydroxide tov (1 hauv 25), thiab sib tov kom yaj.Dilute nrog Buffer rau ntim.
Kev lees txais: +21 ° txog +27 °
pH <791>: 2.0-2.8 hauv kev daws (1 hauv 100)
LOSS ON DRYING <731>: Qhuav ib qho qauv ntawm qhov siab ntawm li 50 hli ntawm mer cury ntawm 70 ° rau 4 h: nws poob NMT 1.0% ntawm nws qhov hnyav.
TSEEM CEEB
PACKAGING THIAB STORAGE: Khaws rau hauv cov thawv ntim nruj, thiab khaws cia ntawm chav tsev kub.
USP REFERENCE STANDARDS <11>
USP Acetylcysteine RS
USP L-Phenylalanine RS
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
Muaj nuj nqi & Kev siv N-Acetyl-L-Cysteine (Ac-Cys-OH; NAC) (CAS: 616-91-1) hmoov
1. N-Acetyl-L-Cysteine, tseem hu ua N-Acetylcysteine lossis Acetylcysteine (NAC), yog cov tshuaj siv tshuaj thiab cov khoom noj khoom haus siv feem ntau ua tus neeg sawv cev mucolytic thiab hauv kev tswj hwm ntawm paracetamol (acetaminophen) overdose.Lwm yam kev siv suav nrog sulfate repletion nyob rau hauv tej yam kev mob, xws li autism, qhov twg cysteine thiab lwm yam sulfur amino acids yuav depleted.
2. N-Acetyl-L-Cysteine yog ib qho derivative ntawm cysteine uas ib pawg acetyl txuas rau cov nitrogen atom.Cov tshuaj no yog muag raws li kev noj haus ntxiv uas feem ntau thov cov tshuaj antioxidant thiab lub siab tiv thaiv cov teebmeem.Nws yog siv los ua tshuaj hnoos vim tias nws rhuav tshem disulfide daim ntawv cog lus hauv cov hnoos qeev thiab liquefies nws, ua rau nws yooj yim rau hnoos.Nws tseem yog qhov kev txiav txim ntawm kev rhuav tshem cov ntawv cog lus disulfide uas ua rau nws muaj txiaj ntsig hauv kev ua kom nyias nyias nyias nyias nyias hauv cov neeg mob cystic thiab pulmonary fibrosis.
3. Acetylcysteine yog cov tshuaj mucolytic uas muaj cov nyhuv mucolytic muaj zog.Cov pab pawg sulfhydryl muaj nyob rau hauv cov molecule tuaj yeem rhuav tshem cov disulfide daim ntawv cog lus hauv glycoprotein polypeptide saw hauv cov hnoos qeev, yog li txo cov viscosity ntawm cov hnoos qeev, thiab ua rau cov hnoos qeev ua kua thiab hnoos yooj yim.Cov khoom no tuaj yeem rhuav tshem DNA fibers hauv purulent hnoos qeev, yog li nws tuaj yeem tsis tsuas yog yaj cov hnoos qeev dawb, tab sis kuj purulent hnoos qeev.Rau cov neeg mob uas cov expectorants feem ntau tsis zoo, cov khoom no tseem tuaj yeem ua tau zoo.
4. Nws yog siv los ua tshuaj yaj cov phlegm.Nws yog siv rau hauv kev tshawb fawb biochemical thiab tshuaj raws li tshuaj tua kab mob rau phlegm thiab acetaminophen lom.Biochemical reagent, tshuaj, cov khoom no yog siv raws li expectorant, hais tias phlegm yog yooj yim los ntxuav.
5. Cov kev mob tshwm sim feem ntau muaj xws li xeev siab thiab ntuav thaum noj los ntawm qhov ncauj.Tej zaum daim tawv nqaij tuaj yeem ua liab thiab khaus ntawm ob daim ntawv.Ib hom kab mob anaphylaxis kuj tshwm sim.Nws zoo nkaus li muaj kev nyab xeeb thaum cev xeeb tub.Rau kev noj tshuaj ntau dhau ntawm paracetamol, nws ua haujlwm los ntawm kev nce qib ntawm glutathione, ib qho antioxidant uas tuaj yeem ua rau cov tshuaj lom neeg puas tsuaj ntawm paracetamol.Thaum nqus tau, nws ua raws li mucolytic los ntawm kev txo qis ntawm cov hnoos qeev.
6. Acetylcysteine yog thawj zaug patented nyob rau hauv 1960 thiab tuaj mus rau kev kho mob nyob rau hauv 1968. Nws yog nyob rau hauv lub World Health Organization's List of Essential Medicines, uas teev cov tshuaj muaj kev nyab xeeb thiab zoo tshaj plaws uas yuav tsum tau nyob rau hauv ib tug noj qab haus huv system.Nws muaj raws li cov tshuaj generic thiab pheej yig.
7. N-Acetyl-L-Cysteine yog daim ntawv acetylated L-cysteine uas yog nqus tau zoo dua thiab siv tau.Nws kuj yog ib qho antioxidant uas pab tiv thaiv kab mob.N-Acetyl-l-Cysteine tau siv los ua lub siab tiv thaiv kab mob thiab ua rau cov kab mob ntsws thiab cov hnoos qeev.
8. N-Acetyl-L-Cysteine tuaj yeem txhawb cov qib glutathione hauv cov hlwb.
9. N-Acetyl-L-Cysteine yog ib qho tseem ceeb ntawm cov amino acids, ib qho ntawm peb tsuas yog sulfur-muaj cov amino acids, lwm tus yog taurine (uas tuaj yeem tsim los ntawm L-cysteine) thiab L-methionine los ntawm L-cysteine tuaj yeem ua tau. yuav tsim nyob rau hauv lub cev los ntawm ib tug ntau yam txheej txheem.
10. N-Acetyl-L-Cysteine tuaj yeem ua cov tshuaj tua kab mob antioxidant, tuaj yeem tiv thaiv kab mob siab, thiab tuaj yeem pab ua kom cov plaub hau tuab ntawm cov plaub hau uas twb muaj lawm yog noj tsis tu ncua.
11. Daim ntawv thov hauv kev kho mob Raws li tus neeg sawv cev ua pa, nws tuaj yeem siv los ua cov tshuaj tua kab mob phlegm drums.nws tuaj yeem kho bronchitis.Ntxiv mus, N-Acetyl-L-Cysteine tuaj yeem siv los ua tshuaj tua kab mob thaum muaj tshuaj lom acetaminophen.
12. Daim ntawv thov hauv cov tshuaj pleev ib ce N-Acetyl-L-Cysteine muaj cov txiaj ntsig zoo hauv kev tshem tawm cov pa dawb radicals thiab lwm yam oxides thiab qeeb cov txheej txheem kev laus, nws kuj tuaj yeem cuam tshuam cov melanin ntau lawm, thiab pab tshem tawm cov freckle ntawm daim tawv nqaij.
13. Daim ntawv thov hauv tsiaj pub N-Acetyl-L-Cysteine tuaj yeem siv los ua cov khoom noj ntxiv.
14. Tshuaj pleev ib ce tsuas yog siv rau kev zoo nkauj dej, perm kua, tshuaj pleev thaiv hnub tiv thaiv daim tawv nqaij.Nws muaj lub luag haujlwm los tiv thaiv kev laus laus.N-Acetyl-l-Cysteine tuaj yeem tiv thaiv thiab kho kev raug mob hluav taws xob zoo.N-acetyl Cysteine tuaj yeem tshem tawm cov tawv nqaij melanin nws tus kheej, hloov qhov xwm txheej ntawm daim tawv nqaij nws tus kheej, daim tawv nqaij ua kom dawb huv.
15. Khoom noj khoom haus ntxiv.Siv hauv khob cij, los txhawb kev tsim cov gluten thiab txhawb fermentation, pwm, tiv thaiv kev laus.Siv hauv cov kua txiv hmab txiv ntoo los tiv thaiv vitamin C los ntawm oxidizing thiab tiv thaiv cov kua txiv hmab txiv ntoo los ntawm cov xim av.
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