N(4)-Hydroxycytidine CAS 3258-02-4 EIDD-1931 NHC High Quality
Muab khoom nrog High Purity thiab ruaj khov zoo
Lub npe tshuaj: N(4)-Hydroxycytidine;EIDD-1931 (NHC)
CAS: 3258-02-4 Nr
Ib qho nquag metabolite ntawm Molnupiravir, cog lus rau COVID-19 inhibitor
| Tshuaj npe | N(4)-Hydroxycytidine |
| Synonyms | EIDD-1931 (NHC);β-D-N4-Hydroxycytidine |
| CAS Nr | 3258-02-4 : kuv |
| CAT Number | Qauv TSIS MUAJ: RF-PI309 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Kilograms |
| Molecular Formula | C9H13N3O6 |
| Molecular Luj | 259.22 Nws |
| Melting Point | 169.0 ~ 172.0 ℃ |
| Solubility | Soluble rau 100 mM hauv DMSO thiab rau 50 mM hauv dej |
| Qhov ntom | 1.93 ± 0.1g / cm3 |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Dawb rau Off-White Powder |
| NMR | Raws li tus qauv |
| Purity / Analysis Method | > 98% (HPLC) |
| Poob rau ziab | ≤ 1.0% |
| Ib leeg Impurity | ≤0.50% |
| Hnyav Hlau | ≤ 20ppm |
| Test Standard | Enterprise Standard |
| Kev siv | Ib qho kev ua haujlwm metabolite ntawm Molnupiravir (EIDD-2801), tus tiv thaiv COVID-19 |
Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.
N(4)-Hydroxycytidine (EIDD-1931, β-d-N4-hydroxycytidine, NHC, CAS 3258-02-4) yog ib qho active metabolite ntawm EIDD-2801, cog lus rau COVID-19 inhibitor.EIDD-1931 (NHC) muaj broad spectrum antiviral activity tiv thaiv ntau tus kab mob coronaviruses, suav nrog SARS-CoV-2, MERS-CoV, SARS-CoV, thiab muaj feem xyuam nrog zoonotic pawg 2b lossis 2c Bat-CoVs nrog nruab nrab IC50 ntawm 0.15 μM, as well as nce zog tiv thaiv tus kabmob coronavirus uas muaj kev hloov pauv mus rau nucleoside analog inhibitor remdesivir.Hauv cov nas kis mob SARS-CoV lossis MERS-CoV, ob qho tib si prophylactic thiab kho kev tswj hwm ntawm Molnupiravir (EIDD-2801), qhov ncauj bioavailable NHC-prodrug (β-D-N4-hydroxycytidine-5'-isopropyl ester), txhim kho pulmonary function. , thiab txo tus kab mob titer thiab lub cev hnyav.Kev txo qis MERS-CoV yields hauv vitro thiab hauv vivo tau cuam tshuam nrog nce kev hloov pauv hloov zaus hauv tus kab mob tab sis tsis yog tus tswv ntawm tes RNA, txhawb nqa lub tswv yim ntawm kev tuag mutagenesis hauv CoV.Lub zog ntawm NHC / EIDD-2801 tawm tsam ntau tus kabmob coronaviruses thiab qhov ncauj bioavailability qhia txog nws cov peev txheej uas muaj peev xwm ua tau zoo los tiv thaiv SARS-CoV-2 thiab lwm yam zoonotic coronaviruses yav tom ntej.
