Pfizer tab tom nrhiav kev tso cai siv thaum muaj xwm txheej ceev los ntawm FDA rau nws cov tshiab Covid-19 tshuaj tiv thaiv kab mob Paxlovid.
Qhia Tshooj
Ntawm qhov heels ntawm Merck antiviral molnupiravir qhov kev pom zoo UK, Pfizer tau npaj kom tau txais nws tus kheej Covid-19 ntsiav tshuaj, Paxlovid, ntawm khw.Lub lim tiam no, Asmeskas cov kws tsim tshuaj tau nrhiav kev tso cai siv thaum muaj xwm txheej ceev los ntawm US Food and Drug Administration (FDA) rau nws cov neeg sib tw tshiab tshuaj tiv thaiv kab mob hauv cov tib neeg uas mob me-rau-nruab nrab Covid-19, uas muaj kev pheej hmoo siab dua mus pw hauv tsev kho mob lossis tuag.Pfizer kuj tseem muaj. pib cov txheej txheem nrhiav kev tswj xyuas kev tswj hwm hauv lwm lub tebchaws suav nrog UK, Australia, New Zealand thiab Kaus Lim Qab Teb, thiab npaj yuav ua cov ntawv thov ntxiv.Paxlovid ua haujlwm li cas?Paxlovid yog kev sib xyaw ua ke ntawm Pfizer qhov kev tshawb nrhiav tshuaj tiv thaiv kab mob PF-07321332 thiab cov koob tshuaj tsawg. ritonavir, ib qho tshuaj tiv thaiv kab mob ib txwm siv los kho HIV.Kev kho mob cuam tshuam qhov kev rov ua dua ntawm SARS-CoV-2 hauv lub cev los ntawm kev khi rau 3CL-zoo li protease, ib qho enzyme tseem ceeb rau tus kab mob kev ua haujlwm thiab kev tsim tawm.
Raws li kev soj ntsuam ib ntus, Paxlovid txo qis txoj kev pheej hmoo ntawm Covid-19-txuas mus pw hauv tsev kho mob lossis tuag los ntawm 89% hauv cov neeg uas tau txais kev kho mob tsis pub dhau peb hnub ntawm cov tsos mob tshwm sim.Cov tshuaj tau pom tias muaj txiaj ntsig zoo - tsuas yog 1% ntawm cov neeg mob uas tau txais Paxlovid tau pw hauv tsev kho mob txog hnub 28 piv rau 6.7% ntawm cov neeg koom nrog cov placebo- tias nws qhov kev sim Phase II / III tau xaus ntxov thiab kev tswj hwm kev xa mus rau FDA tau foob sai dua. xav tau.Ntxiv mus, thaum 10 tus neeg tuag tau tshaj tawm ntawm cov placebo caj npab, tsis muaj ib qho tshwm sim ntawm cov neeg koom uas tau txais Paxlovid.Zoo li molnupiravir, Paxlovid tau muab tshuaj rau qhov ncauj, txhais tau tias Covid-19 cov neeg mob tuaj yeem noj cov tshuaj hauv tsev thaum ntxov ntawm kev kis tus kabmob.Qhov kev cia siab yog tias cov tshuaj tiv thaiv kab mob tshiab zoo li cov los ntawm Merck thiab Pfizer yuav tso cai rau cov neeg mob me lossis nruab nrab ntawm tus mob coronavirus tau kho sai dua, tiv thaiv kev kis tus kab mob thiab pab kom tsis txhob muaj tsev kho mob dhau los.
Covid-19 kev sib tw tshuaj yeeb tshuajMerck's molnupiravir, thawj ntsiav tshuaj pom zoo rau Covid-19, tau tshaj tawm tias muaj peev xwm hloov pauv kev ua si txij li kev tshawb fawb pom tias nws txo qis kev mus pw hauv tsev kho mob thiab kev pheej hmoo tuag los ntawm ib puag ncig 50%.Tab sis qhov ntawd tsis tau txhais hais tias Pfizer's antiviral muab yuav tsis muaj ntug hauv khw.Kev soj ntsuam ib ntus ntawm molnupiravir qhov kev ua tau zoo yog qhov zoo, tab sis qhov kev pheej hmoo txo qis tshaj tawm los ntawm Pfizer qhia tias nws cov ntsiav tshuaj kuj tseem tuaj yeem ua pov thawj muaj txiaj ntsig zoo hauv tsoomfwv cov tub rog tiv thaiv tus kabmob kis thoob qhov txhia chaw. sib tw antiviral.Qee tus kws tshaj lij tau hais txog kev txhawj xeeb tias molnupiravir lub tswv yim ntawm kev tawm tsam Covid-19 - ua raws li RNA cov molecules los ua kom muaj kab mob sib kis - kuj tuaj yeem qhia txog kev hloov pauv tsis zoo hauv tib neeg DNA.Paxlovid, ib hom tshuaj tiv thaiv kab mob sib txawv hu ua protease inhibitor, tsis tau qhia tias tsis muaj "kev cuam tshuam DNA mutagenic", Pfizer tau hais.
Post lub sij hawm: Nov-19-2021