Octreotide Acetate CAS 83150-76-9 Peptide Purity (HPLC) ≥98.0% API Zoo

Octreotide Acetate (Sandostatin) yog ib qho hluavtaws peptide analogue ntawm cov tshuaj hormone somatostatin, nws yog ib qho kev ua haujlwm ntev somatostatin analog qhia rau kev tswj cov tsos mob hauv acromegaly thiab gastroenteropancreatic qog.Lwm yam kev siv hauv kev tshawb nrhiav suav nrog ntshav qab zib, psoriasis thiab Alzheimer's kab mob.Octreotide Acetate (Sandostatin) yog ib qho hluavtaws peptide analogue ntawm cov tshuaj hormone somatostatin.Nws cov yeeb yam suav nrog inhibition ntawm pituitary secretion ntawm kev loj hlob hormone thiab inhibition ntawm pancreatic islet cell secretion ntawm insulin thiab glucagon.Tsis zoo li somatostatin, uas muaj plasma ib nrab-lub neej ntawm ob peb feeb, Octreotide muaj plasma tshem tawm ib nrab-lub neej ntawm 1 mus rau 2 teev.Excretion ntawm cov tshuaj feem ntau yog lub raum.Octreotide txo cov plab hnyuv motility thiab inhibits contraction ntawm lub gallbladder.

Cov tshuaj Peptide Novartis Sandostatin (Octreotide Acetate), yog ib qho khoom siv ntuj tsim somatostatin octapeptide derivatives, nws khaws cov tshuaj pharmacological zoo ib yam li somatostatin, thiab cov nyhuv yog kav ntev.Cov lus qhia rau Octreotide Acetate suav nrog acromegaly;Kev txo qis ntawm cov tsos mob thiab cov tsos mob cuam tshuam nrog kev ua haujlwm gastroenteropancreatic endocrine neoplasia;Thiab kev ua tau zoo hauv Carcinoid hlav nthuav tawm nrog carcinoid syndrome, VIP qog, thiab cov qog glucagon.Tsis tas li ntawd, Octreotide Acetate rau gastrinomas / Zollinger-Ellison syndrome (feem ntau yog ua ke nrog proton twj tso kua mis inhibitors los yog H2 receptor blockers), Insulinomas (kev tiv thaiv ua ntej ntawm hypoglycemia thiab kev saib xyuas ntawm cov ntshav qab zib ib txwm), qhov ua tau zoo ntawm kev loj hlob hormone tso tawm cov qog nqaij hlav. txog 50%.

Octreotide Acetate yog lub teb chaws pov hwm kev noj qab haus huv Class B tshuaj, uas yog ib tug hluavtaws ntuj octapeptide derivative ntawm somatostatin, piv nrog ntuj somatostatin, ib nrab-lub neej ntawm somatostatin yog obviously ntev thiab muaj tib lub pharmacological teebmeem, nrog rau inhibition ntawm kev loj hlob hormone muaj nuj nqi, inhibition. Kev ua haujlwm ntawm lub plab zom mov, pancreatic enzymes, glucagon thiab insulin secretion, thiab txo qis cov ntshav visceral, txo qis kev ua haujlwm ntawm lub plab.Piv nrog rau cov haiv neeg somatostatin, octreotide muaj ib nrab-lub neej ntev, muaj kev xaiv ntau dua rau inhibition ntawm kev loj hlob hormone secretion dua li inhibition ntawm insulin secretion, thiab tsis ua rau rebound hypersecretion ntawm cov tshuaj hormones.1, Kev tswj kev phais lossis kev kho hluav taws xob tsis tuaj yeem tswj tau tus kab mob txaus rau cov neeg mob acromegaly cov tsos mob thiab txo tus neeg mob qhov kev loj hlob hormone (GH) zoo li insulin-zoo li kev loj hlob ntawm -1 (1GF-1) plasma qib.Sandostatin kuj tseem siv tau los kho cov neeg mob acromegaly uas tsis tuaj yeem lossis tsis kam mus phais, lossis kho cov neeg mob acromegaly uas tseem tsis tau muaj kev kho hluav taws xob.2. Kev txo qis ntawm cov tsos mob cuam tshuam nrog kev ua haujlwm gastroenteropancreatic (GEP) cov qog endocrine xws li qog nqaij hlav carcinoid nrog carcinoid syndrome tshwm sim.Sandostatin tsis yog tshuaj tua kab mob thiab tsis kho cov neeg mob no.3, Tiv thaiv cov teeb meem tom qab phais mob pancreatic.4, Cov neeg mob siab cirrhosis nrog gastric-esophageal variceal los ntshav tshwm sim los ntawm kev kho mob xwm txheej ceev, hemostasis thiab tiv thaiv kev los ntshav, Sandostatin yuav tsum tau ua ke nrog endoscopic sclerotherapy thiab lwm yam kev kho tshwj xeeb.