Olaparib AZD-2281 CAS 763113-22-0 Purity ≥99.0% API Hoobkas
High Purity, Kev lag luam ntau lawm
Olaparib thiab Related Intermediates:
Olaparib CAS 763113-22-0
2-Fluoro-5-Formylbenzonitrile CAS 218301-22-5
2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid CAS 763114-26-7
1- (Cyclopropylcarbonyl) Piperazine Hydrochloride CAS 1021298-67-8
Tom ntej: 3-Oxo-1,3-Dihydroisobenzofuran-1-Ylphosphonic Acid CAS 61260-15-9
| Tshuaj npe | Olaparib |
| Synonyms | ZD-2281;KU0059436;Lynparza;4-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-ib;1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazin |
| CAS Nr | 763113-22-0 |
| CAT Number | RF-API 103 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale nce mus txog pua pua ntawm Kilograms |
| Molecular Formula | C24H23FN4O3 |
| Molecular Luj | 434.46 ib |
| Solubility | Soluble hauv DMSO |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Dawb rau Off-White Powder |
| Kev txheeb xyuas los ntawm 1H NMR | Ua raws li tus qauv |
| LC-MS | Ua raws li tus qauv |
| Purity / Analysis Method | ≥99.0% (los ntawm LC-MS) |
| Moisture (KF) | ≤0.50% |
| Ib leeg Impurity | ≤0.50% |
| Tag nrho cov impurities | ≤ 1.0% |
| Heavy Metals (raws li Pb) | ≤ 20ppm |
| Test Standard | Enterprise Standard |
| Kev siv | API;PARP Inhibitor Cov |
Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard Nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo.
Olaparib (CAS: 763113-22-0), muaj zog thiab xaiv PARP-inhibitor.Thaum Lub Kaum Ob Hlis 19, 2014, FDA tau pom zoo tshiab tshuaj tiv thaiv kab mob qog noj ntshav Olaparib (Lynparza) rau kev kho mob monotherapy rau cov neeg mob ntawm cov qog nqaij hlav zes qe menyuam uas tau dhau los tsawg kawg 3 qhov kev kho mob los yog cov neeg mob xav tias BRCA hloov pauv.Nyob rau tib lub sijhawm, FDA pom zoo kom muaj nuj nqis thiab kev faib tawm ntawm cov khoom siv kuaj mob rau kev kuaj pom kev hloov pauv hauv BRCA1 thiab BRCA2, BRACAnalysis CDx.Olaparib yog thawj PARP inhibitor tshuaj uas tau pom zoo los ntawm FDA.Thaum Lub Ob Hlis 2, 2015, European Union Food and Drug Administration (EMA) kuj pom zoo Olaparib nkag mus rau hauv kev ua lag luam hauv 28 lub teb chaws ntawm European Union suav nrog Iceland, Liechtenstein thiab Norway.Tab sis cov lus qhia ntawm EMA thiab FDA pom zoo yog txawv me ntsis;yav dhau los yog rau BRCA noob kev hloov pauv, thiab tseem rau kev kho mob rau cov neeg mob ntawm kev mob qog noj ntshav ntawm zes qe menyuam uas tau txais platinum-muaj cov tshuaj khomob yav dhau los thiab nthuav tawm cov lus teb thiab raug rov ua dua.
