Polymyxin B Sulfate CAS 1405-20-5 Assay Microbiological ≥6500 IU/mg Hoobkas
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom thiab cov chaw muag khoom ntawm Polymyxin B Sulfate (CAS: 1405-20-5) nrog cov khoom zoo.Peb tuaj yeem muab COA, xa khoom thoob ntiaj teb, me me thiab ntau ntau.Yog tias koj txaus siab rau Polymyxin B Sulfate,Please contact: alvin@ruifuchem.com
| Tshuaj npe | Polymyxin B Sulfate |
| Synonyms | Polymyxin B Sulfate ntsev;Aerosporin;Mastimyxin;PXNS;PMB;Poly-RX |
| Tshuag xwm txheej | Hauv Tshuag, Muaj Peev Xwm Ntau Lawm 10 Tons ib xyoos |
| CAS Nr | 1405-20-5 : kuv |
| Molecular Formula | C55H96N16O13 · 2H2SO4 |
| Molecular Luj | 1301.56 Nws |
| Melting Point | 217.0 ~ 220.0 ℃ (Lub Kaum Ob Hlis) |
| rhiab heev | Hygroscopic.Sensitive rau lub teeb thiab kub |
| Dej Solubility | Soluble hauv dej, 50 mg / mL.Me ntsis Soluble hauv Ethanol |
| COA & MSDS | Muaj |
| Qauv | Muaj |
| Hom | Ruifu Tshuaj |
| Cov khoom | Specifications | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb los yog Yuav luag nrog Crystalline Hmoov | Ua raws |
| Kev txheeb xyuas A. Lub sijhawm khaws cia ntawm qhov loj peaks los ntawm cov qauv kev daws teeb meem sib haum rau cov txheej txheem kev daws teeb meem, raws li tau txais hauv qhov kev sim rau muaj pes tsawg leeg ntawm Polymyxins. | Ua raws | |
| PH (2%) | 5.0 ~ 7.0 | 5.7 |
| PH (0.5%) | 5.0 ~ 7.5 hli | 5.5 |
| Sulfated tshauv | ≤ 0.75% |
|
| Kev sib hloov tshwj xeeb [α]20/D | -78.0° ~ -90.0°(C=2, H2O) (Calcd. on Anh. Tshuaj) | -85.0 ° |
| Sulfate | 15.5 ~ 17.5% | 16.65% |
| Poob rau ziab | ≤ 6.00% | 3.0% |
| Residue ntawm Ignition | ≤0.10% | 0.02% |
| Hnyav Hlau | ≤ 20ppm | ≤ 20ppm |
| Phenylalanine | 9.0 ~ 12.0% | 9.8% |
| Tag nrho Viabel Aerobic suav | ≤10cfu/g | ≤10cfu/g |
| Yam khoom muaj feem xyuam, HPLC |
|
|
| Tus kheej impurity | ≤ 3.0% | 2.723% |
| Tag nrho cov impurities | ≤ 17.0% | 16.223% |
| Kev ntsuam xyuas HPLC (ODB) | Cov txiaj ntsig ntawm Polymyxins B1, B2, B3 thiab B1-1: ≥80.0% | 86.6% |
| Polymyxin B3: ≤ 6.0% | 3.8% | |
| Polymyxin B1-1: ≤15.0% | 8.5% | |
| Assay, Microbiological (raws li yog) | ≥6500lU/mg | 8255 IU/mg |
| Particle Loj | ≥99.0% ≤30um los ntawm vol | Ua raws |
| ≥90.0% ≤25um los ntawm vol | ||
| ≥75.0% ≤20um los ntawm vol | ||
| ≥35.0% ≤10um los ntawm vol | ||
| Xaus | Cov khoom ua raws li USP42 |
|
Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Lub teeb rhiab heev.Khaws lub thawv kaw kom nruj thiab khaws cia rau hauv qhov chaw txias, qhuav (2 ~ 8 ℃) thiab lub tsev tso cua txias kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.Incompatible nrog muaj zog oxidizing neeg sawv cev.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
Hazard Symbols Xn - Ua phem
Risk Codes 22 - Ua phem yog tias nqos tau
Safety Description S22 - Tsis txhob ua pa plua plav.
S24/25 - Tsis txhob sib cuag nrog daim tawv nqaij thiab qhov muag.
UN IDs 3249
WGK Germany 3
RTECS TR1150000
FLUKA BRAND F CODE 3-8-10
HS Code 2941909099
Hazard Class 6.1(b)
Packing Group III
Polymyxin yog ib pawg ntawm cov tshuaj tua kab mob polypeptide uas tsim los ntawm Bacillus polymyxa (bacilluspolymyxa).Polymyxin B thiab E yog siv rau kev kho mob, thiab lawv cov sulfates feem ntau yog siv.Cov tshuaj tua kab mob spectrum thiab kev kho mob ntawm Polymyxin B Sulfate zoo ib yam li cov polymyxin E. Nws muaj inhibitory los yog bactericidal teebmeem ntawm gram-negative bacilli, xws li Escherichia coli, Pseudomonas aeruginosa, paracilli, Klebsiella pneumoniae, acidsisophilus,
Polymyxin Sulfate B zoo ib yam li polymyxin e, thiab muaj inhibitory lossis bactericidal teebmeem ntawm gram-negative bacilli, xws li e.coli, pseudomonas aeruginosa, paracilli, Klebsiella pneumoniae, acidophilus, bacilli pertussis thiab dysentery bacilli.Nws yog tsuas yog siv nyob rau hauv lub qhov txhab, urinary ib ntsuj av, qhov muag, pob ntseg, trachea thiab lwm qhov chaw ntawm tus kab mob tshwm sim los ntawm Pseudomonas aeruginosa thiab lwm yam Pseudomonas.Nws kuj tseem siv tau rau sepsis thiab peritonitis.Thiab cov kab mob hnyav tshwm sim los ntawm aminoglycosides, thib peb tiam cephalosporin-resistant kab mob, Pseudomonas aeruginosa los yog lwm yam kab mob rhiab heev, xws li bacteremia, endocarditis, mob ntsws, kab mob tom qab hlawv, thiab lwm yam.
1. Intravenous drip: cov neeg laus thiab cov menyuam yaus uas lub raum ua haujlwm li qub 1.5 ~ 2.5mg ib kilogram ntawm lub cev hnyav (feem ntau tsis tshaj 2.5mg ib kilogram ntawm lub cev hnyav) rau 1 hnub, muab faib ua 2 zaug, drip ib zaug txhua 12 teev.Txhua 50mg ntawm cov khoom no yog diluted nrog 500ml ntawm 5% qabzib tov thiab ces dripped.Cov menyuam mos uas muaj lub raum ua haujlwm tsis zoo tuaj yeem tiv taus 4mg ib kilogram ntawm lub cev hnyav rau 1 hnub.2. Kev txhaj tshuaj intramuscular: cov neeg laus thiab menyuam yaus: 2.5 ~ 3mg ib kilogram ntawm lub cev hnyav ntawm 1st, muab rau hauv batch, ib zaug txhua 4 ~ 6 teev.Cov menyuam mos tuaj yeem ncav cuag 4mg ib kilogram ntawm lub cev hnyav ib hnub thiab cov menyuam mos tuaj yeem ncav cuag 4.5mg ib kilogram ntawm lub cev hnyav.3. Kev txhaj tshuaj Intrathecal (rau Pseudomonas aeruginosa meningitis): 5mg ib milliliter ntawm cov tshuaj ua kua npaj nrog kev txhaj tshuaj sodium chloride.Cov neeg laus thiab menyuam yaus hnub nyoog qis dua 2 xyoos, 5mg txhua hnub, tom qab 3-4 hnub ntawm daim ntawv thov, hloov mus rau ib zaug txhua hnub, tsawg kawg 2 lub lis piam, kom txog rau thaum cov kab mob cerebrospinal tsis zoo, thiab cov ntsiab lus qab zib zoo li qub.Rau cov menyuam yaus hnub nyoog qis dua 2 xyoos, siv 2mg ib hnub ib zaug rau 3-4 hnub sib law liag (lossis 2.5mg ib zaug ib hnub), thiab tom qab ntawd siv 2.5mg ib zaug ib hnub kom txog thaum qhov kev kuaj ntawd zoo li qub.4. Qhov concentration ntawm qhov muag tee yog 1 ~ 2.5mg ib ml.
Tsis txhob sib xyaw nrog cov tshuaj uas ua rau lub raum puas, cov leeg pob txha so, cov tshuaj tua kab mob aminoglycoside, tshuaj loog uas muaj cov leeg nqaij so kom pom tseeb (xws li enflurane), thiab lwm yam, thiab quinine, magnesium, thiab lwm yam tsis tuaj yeem siv intravenously tib lub sijhawm.Polymyxin B sulfate yog ua ke nrog sulfonamides, rifampicin, semi-synthetic penicillin, thiab lwm yam, rau kev kho mob ntawm cov kab mob hnyav-resistant gram-negative kab mob, thiab cov nyhuv yog zoo dua li ntawm ib daim ntawv thov.
1, Cov poj niam cev xeeb tub thiab lactating poj niam, menyuam yaus, thiab cov neeg mob uas muaj lub raum tsis txaus muaj ntau dua.2. Cov khoom no muaj tshuaj lom heev thiab muaj cov nyhuv curative tsis zoo ntawm cov ntaub so ntswg sib sib zog nqus.Nws tsis yog thawj qhov kev xaiv rau kev kis kab mob.3. Kev txhaj tshuaj rau hauv cov hlab ntsha tuaj yeem ua rau ua pa nyuaj, uas feem ntau tsis siv.Yam tsawg kawg yog ib nrab ntawm cov koob tshuaj txhua hnub yuav tsum tau tso dej hauv cov hlab ntsha, tsis yog lub bolus ceev ib zaug, kom tsis txhob muaj cov kab mob neuromuscular.4. Nws yuav tsum tsis txhob ua ke nrog lwm cov tshuaj nrog nephrotoxicity lossis neuromuscular blockade kom tsis txhob muaj xwm txheej.
Kev tshawb fawb biochemical.Polymyxin B yog ib qho tshuaj tiv thaiv kab mob-gram-tsis zoo bacilli polypeptide tshuaj tua kab mob, uas tuaj yeem hloov cov qauv ntawm daim nyias nyias kom xau me me molecules thiab inhibit qhov kev loj hlob ntawm cov kab mob gram-tsis zoo.Nws muaj cov kab mob bactericidal ntawm Escherichia coli.Lipid A moieties khi rau cov kab mob lipopolysaccharides.Me me pores yog induced nyob rau hauv daim tawv nqaij txheej cell membrane.Hom kev ua: khi thiab cuam tshuam nrog permeability ntawm cytoplasmic membrane.Antibacterial spectrum: Cov kab mob Gram-negative.
Polymyxin B, sulfate.
Polymyxin B Sulfate [1405-20-5].
» Polymyxin B Sulfate yog sulfate ntsev ntawm ib hom polymyxin, ib yam khoom tsim los ntawm kev loj hlob ntawm Bacillus polymyxa (Prazmowski) Migula (Fam. Bacillaceae), los yog sib tov ntawm ob los yog ntau tshaj xws li ntsev.Nws muaj lub zog ntawm tsis pub tsawg dua 6000 Polymyxin B units ib mg, suav nrog lub hauv paus qhuav.
Ntim thiab khaws cia-Txuag hauv cov thawv nruj, lub teeb-tiv taus.
Labeling-Qhov twg ntim rau cov ntawv sau tshuaj, daim ntawv lo qhia cov naj npawb ntawm Polymyxin B Units nyob rau hauv lub thawv thiab ib milligram, tias nws tsis yog npaj rau kev tsim khoom siv, tias nws tsis muaj menyuam tsis taus, thiab nws lub zog tsis tuaj yeem paub tseeb ntev dua 60 hnub tom qab qhib.Qhov twg nws yog npaj los siv rau hauv kev npaj cov tshuaj txhaj tshuaj los yog lwm yam tshuaj tsis muaj menyuam, daim ntawv lo hais tias nws tsis muaj menyuam lossis yuav tsum tau ua haujlwm ntxiv thaum lub sijhawm npaj cov tshuaj txhaj lossis lwm yam tshuaj tsis muaj menyuam.
USP Reference cov qauv <11>-
USP Polymyxin B Sulfate RS
Kev txheeb xyuas-
A: Liquid Chromatographic Identification Test-
Txawb theem-Npaj sib tov ntawm 0.1 M tribasic sodium phosphate thiab acetonitrile (77:23), thiab kho nrog phosphoric acid rau pH ntawm 3.0.Ua kev hloov kho yog tias tsim nyog (saib System Suitability hauv Chromatography <621>.
Standard tov- Npaj ib qho kev daws ntawm USP Polymyxin B Sulfate RS nyob rau hauv Mobile theem muaj ib tug concentration ntawm txog 3.5 mg ib mL.Tiv thaiv cov tshuaj no los ntawm lub teeb.
Test solution-Npaj ib qho kev daws ntawm Polymyxin B Sulfate nyob rau hauv Mobile theem uas muaj ib tug concentration ntawm txog 3.5 mg ib mL.Tiv thaiv cov tshuaj no los ntawm lub teeb.
Chromatographic system (saib Chromatography <621>)-Cov kua chromatograph yog nruab nrog 212-nm detector thiab 4.6-mm × 25-cm kem uas muaj 5-µm packing L1.Tus nqi ntws yog li 1 mL ib feeb.
Cov txheej txheem-Kev txhaj tshuaj sib npaug (kwv yees li 10 µL) ntawm cov txheej txheem kev daws teeb meem thiab cov tshuaj ntsuam xyuas rau hauv chromatograph, thiab sau cov chromatograms.Cov chromatogram tau txais los ntawm Kev Ntsuas Kev Ntsuas sib raug zoo rau qhov tau txais los ntawm Cov Txheej Txheem Kev daws teeb meem, nthuav tawm lub ncov loj sib xws rau polymyxin B1 thiab peaks ntawm cov txheeb ze tuav lub sijhawm kwv yees li 0.5 (polymyxin B2) thiab 0.6 (polymyxin B3).
B: Dissolve 2 mg nyob rau hauv 5 mL dej, ntxiv 5 mL ntawm 2.5 N sodium hydroxide, sib tov, thiab ntxiv 5 tee ntawm cupric sulfate tov (1 ntawm 100), co tom qab sib ntxiv ntawm txhua tee: ib tug reddish violet xim yog tsim. .
C: Ib qho kev daws teeb meem (1 hauv 20) ua tau raws li qhov yuav tsum tau ua ntawm kev sim rau Sulfate <191>.
pH <791>: nruab nrab ntawm 5.0 thiab 7.5, hauv cov tshuaj muaj 5 mg ib mL.
Poob ntawm ziab <731>-Sry txog 100 mg, hnyav hnyav, hauv lub raj mis capillary-stoppered hauv lub tshuab nqus tsev ntawm 60 ℃ rau 3 teev: nws poob tsis ntau tshaj 7.0% ntawm nws qhov hnyav.
Cov ntsiab lus ntawm phenylalanine-Hloov txog 0.375 g ntawm Polymyxin B Sulfate, raug hnyav, mus rau 100-mL ntim ntim, yaj hauv thiab dilute nrog 0.1 N hydrochloric acid rau ntim, thiab sib tov.Ntsuas cov absorbances ntawm cov tshuaj no ntawm qhov maxima ntawm 264 nm (A264), 258 nm (A258), thiab 252 nm (A252), thiab absorbances ntawm 280 nm (A280) thiab 300 nm (A300).Xam cov feem pua ntawm phenylalanine hauv feem ntawm Polymyxin B Sulfate coj los ntawm cov mis:
(9.4787/W)(A258 - 0.5A252 + 0.5A264 - 1.84A280 + 0.8A300)
nyob rau hauv uas W yog qhov hnyav, nyob rau hauv g, ntawm Polymyxin B Sulfate noj: nws muaj nyob nruab nrab ntawm 9% thiab 12% ntawm phenylalanine, xam nyob rau hauv qhuav.
Lwm qhov yuav tsum tau ua- Yog tias muaj cov ntawv sau tshuaj, nws ua tau raws li qhov yuav tsum tau muaj rau Residue ntawm ignition nyob rau hauv Polymyxin B rau Txhaj.Qhov twg daim ntawv lo hais tias Polymyxin B Sulfate yog tsis muaj menyuam, nws ua tau raws li qhov yuav tsum tau rau Sterility Tests <71> thiab, qhov twg npaj rau txhaj tshuaj, rau Pyrogen nyob rau hauv Polymyxin B rau Txhaj.Qhov twg daim ntawv lo hais tias Polymyxin B Sulfate yuav tsum tau ua ntxiv thaum lub sij hawm npaj cov tshuaj txhaj tshuaj, nws ua tau raws li qhov yuav tsum tau rau Pyrogen nyob rau hauv Polymyxin B rau Txhaj.
Assay-Proceed with Polymyxin B Sulfate raws li qhia nyob rau hauv Antibiotics-Microbial Assays <81>.
