Posaconazole CAS 171228-49-2 API Hoobkas Triazole Antifungal Agent Siab Zoo
Factory Supply Posaconazole Related Intermediates, Commercial Production
Posaconazole CAS 171228-49-2
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Tshuaj npe | Posaconazole |
Synonyms | POS;SCH 56592;4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl] methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one |
CAS Nr | 171228-49-2 |
CAT Number | RF-API 77 |
Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale nce mus txog pua pua ntawm Kilograms |
Molecular Formula | C37H42F2N8O4 |
Molecular Luj | 700.78 ib |
Qhov ntom | 1.36 g / cm3 |
Solubility | Soluble hauv DMSO, Insoluble hauv dej |
Shipping Condition | Shipped nyob rau hauv ambient kub |
Hom | Ruifu Tshuaj |
Yam khoom | Specifications |
Qhov tshwm sim | Dawb rau Off-White Crystalline Hmoov |
Kev Taw Qhia A | IR: Infrared absorption spectrum ntawm cov khoom yuav tsum ua raws li cov khoom siv |
Kev Qhia B | HPLC Lub sijhawm khaws cia zoo ib yam li cov khoom siv |
Melting Point | 167.0 ~ 171.0 ℃ |
Kev sib hloov tshwj xeeb [a]20 | -24.0° ~ -28.0° (C = 1, CHCL3) |
Dej (KF) | ≤ 1.0% |
Residue ntawm Ignition | ≤0.10% |
Yam khoom muaj feem | |
TSI 909-24 | ≤ 0.20% |
Txhua tus neeg impurity | ≤0.10% |
Tag nrho cov impurities | ≤ 1.0% |
Residual Solvents | |
Methanol | ≤3000ppm |
Methyl tert-Butyl Ether | ≤5000ppm |
Isopropanol | ≤5000ppm |
Dimethyl Sulfoxide | ≤5000ppm |
Dichloromethane | ≤600ppm |
Assay | 98.0% ~ 102.0% (Xau ntawm lub hauv paus qhuav) |
Hnyav Hlau | ≤10ppm |
Isomer | Enantiomer ≤0.10% |
Txhua tus neeg impurity ≤0.10% | |
Tag nrho impurities ≤1.0% | |
Test Standard | Enterprise Standard;USP;BP;EP Txheem |
Kev siv | API, Triazole Antifungal Agent |
Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.
Posaconazole (CAS 171228-49-2), yog ib tug dav-spectrum, thib ob tiam, triazole compound nrog antifungal kev ua si, launched nyob rau hauv lub UK, yog tus tshiab tshaj plaws tswv cuab ntawm azole chav kawm ntawv ntawm cov tshuaj tua kab mob mus txog lub khw.Nws yog qhia rau kev kho mob thiab kev tiv thaiv ntawm ntau yam kab mob ntawm cov kab mob fungal, suav nrog aspergillosis, fusariosis, chromoblastomycosis, mycetoma, thiab coccidiomycosis hauv cov neeg mob uas tsis kam lees, lossis tsis kam lees, kev kho tus qauv nrog amphotericin B thiab / lossis itraconazole.Hauv Teb Chaws Asmeskas, nws tau pom zoo rau kev tiv thaiv kab mob ntawm tus kab mob Aspergillus thiab Candida hauv cov neeg mob hnub nyoog 13 xyoos uas muaj kev pheej hmoo siab ntawm kev tsim cov kab mob no vim yog kev tiv thaiv kab mob hnyav.Tsis tas li ntawd, nws tau pom zoo rau kev kho mob ntawm oropharyngeal candidiasis.Posaconazole muaj qhov nthuav dav ntawm kev ua haujlwm tshaj lwm cov tswv cuab ntawm azole antifungals.Ntxiv nrog rau kev ua haujlwm muaj zog tiv thaiv cov teeb meem ntawm aspergillosis thiab fluconazole-resistant Candida, nws qhia kev ua haujlwm tawm tsam Zygomycetes.Posaconazole yog ib qho tshuaj tua kab mob triazole muag hauv Tebchaws Meskas los ntawm Schering-Plough raws li lub npe lag luam Noxafil.