Pregabalin CAS 148553-50-8 Purity > 99.0% (HPLC) Antiepileptic API
Chaw tsim tshuaj paus nrog High Purity thiab Commercial Production
Lub npe tshuaj: PregabalinCAS: 148553-50-8 Nr
Pregabalin yog ib hom tshuaj tiv thaiv kab mob thib ob (AED)
Tshuaj npe | Pregabalin |
Synonyms | (S)-3-(Aminomethyl)-5-Methylhexanoic Acid;PD-144723;PIB 144723;CI 1008;CI-1008;Lyrica |
CAS Nr | 148553-50-8 |
CAT Number | RF-API 57 |
Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
Molecular Formula | C8H17NO2 |
Molecular Luj | 159.23 Nws |
Melting Point | 194.0 ~ 196.0 ℃ |
Solubility hauv dej | Xyaum Insoluble hauv dej |
Solubility | Heev me ntsis Soluble nyob rau hauv Ethanol |
Shipping Condition | Nyob rau hauv Ambient Kub |
Hom | Ruifu Tshuaj |
Yam khoom | Specifications |
Qhov tshwm sim | Dawb rau Off-White Crystalline Hmoov |
Kev txheeb xyuas | IR: Zoo ib yam li Cov Khoom Siv |
Kev sib hloov tshwj xeeb | +10.0 ° ~ + 13.0 ° C = 1, Dej) |
Poob rau ziab | <0.50% |
Sulfated tshauv | <0.10% |
Yam khoom muaj feem | Qhov tsis zoo A <0.15% |
Unspecified Impurities Eluting Ua ntej Pregabalin (test A) <0.10% | |
Unspecified Impurities Eluting Tom qab Pregabalin (test B) <0.10% | |
Tag nrho rau kev xeem A thiab B <0.50% | |
Purity Los ntawm HPLC R-Isomer | <0.15% |
Heavy Metals (raws li Pb) | <10ppm |
Chlorides (Cl) | <0.05% |
Residual Solvents | |
Isopropyl cawv | <5000ppm |
Ethyl Acetate | <5000ppm |
Tetrahydrofuran | <250ppm |
Isopropyl Ether hmoov | <500ppm |
Ethanol | <1000ppm |
Purity / Analysis Method | > 99.0% (HPLC ntawm qhuav hauv paus) |
Test Standard | Enterprise Standard |
Kev siv | Antiepileptic Drug API |
Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb & noo noo
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Pregabalin yog ib hom tshuaj antiepileptic thib ob (AED) paub nrog lub npe ntawm Lyrica (Pfizer, Tadworth) hauv UK thiab Asmeskas, muaj γ-amino butyric acid qauv ntawm nws cov qauv molecular, uas muaj cov nyhuv anticonvulsant, thiab yog ntse tsim los ntawm lub tuam txhab Pfizer rau kev kho mob ntawm peripheral neuropathic mob, los yog adjuvant kev kho mob ntawm ib feem qaug dab peg.Pregabalin yog tshuaj Anticonvulsant thiab antiepileptic tshuaj siv los kho mob qaug dab peg, mob neuropathic, fibromyalgia, thiab kev ntxhov siab dav dav.Nws siv rau kev qaug dab peg yog raws li kev kho mob ntxiv rau kev qaug dab peg ib nrab nrog lossis tsis muaj kev cuam tshuam rau cov neeg laus.Thaum Lub Kaum Ob Hlis 2008, US Food and Drug Administration (FDA) tau pom zoo pregabalin (lub npe lag luam "Lyrica") rau kev kho mob ntshav qab zib peripheral neuropathic mob (DPN) thiab postherpetic neuralgia (PHN) uas yog ob qho tib si feem ntau cov mob neuropathic.Pregabalin muaj ib qho kev pom zoo thiab siv dav rau kev kho mob ntawm kev ntxhov siab.Ob peb randomized, ob-dig muag, placebocontrolled trials pom tias pregabalin yog ib qho kev kho mob zoo rau cov neeg mob uas muaj kev ntxhov siab vim thiab kev ntxhov siab vim kev sib raug zoo.koob tshuaj titration Epilepsy-adjunctive therapy: 25 mg bd rau 7 hnub, yuav tsum tau nce 50 mg txhua 7 hnub;ib txwm saib xyuas 300 mg txhua hnub, muab faib ua 2 lossis 3 koob tshuaj (max. 600 mg txhua hnub, muab faib ua 2 lossis 3 koob).Kev ntxhov siab dav dav: 150 mg txhua hnub, muab faib ua 2 lossis 3 koob, rau 7 hnub, yuav tsum tau nce ntxiv 150 mg txhua 7 hnub (max. 600 mg txhua hnub, muab faib ua 2 lossis 3 koob).Yog tias txwv tsis pub pregabalin, nws raug nquahu kom taper dhau tsawg kawg 1 lub lis piam kom tsis txhob tshem tawm sai.Ceeb toom Cov neeg mob uas muaj tej yam mob uas yuav ua rau encephalopathy.Cov neeg mob uas mob congestive plawv tsis ua hauj lwm.
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