Pyrazinamide CAS 98-96-4 Purity > 99.0% (HPLC)
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Tshuaj npe | Pyrazinamide |
Synonyms | Pyrazinecarboxamide;Pyrazinoic Acid Amide |
CAS Nr | 98-96-4 ib |
CAT Number | Qauv TSIS MUAJ: RF-PI2156 |
Tshuag xwm txheej | Hauv Tshuag, Muaj Peev Xwm Ntau Lawm 20 Tons / Lub Hlis |
Molecular Formula | C5H5N3O |
Molecular Luj | 123.11 Nws |
Hom | Ruifu Tshuaj |
Yam khoom | Specifications |
Qhov tshwm sim | Dawb Crystalline hmoov |
Purity / Analysis Method | > 99.0% (HPLC) |
Purity / Analysis Method | 99.0 ~ 101.0% (Titration) |
Melting Point | 188.0 ~ 192.0 ℃ |
Dej (KF) | <0.50% |
Hnyav Hlau | ≤10ppm |
Sulfated tshauv | <0.10% |
Infrared Spectrum | Raws li tus qauv |
Solubility hauv H2O | Tsis muaj xim, ntshiab, 50 mg / mL hauv H2O Pass |
Ib leeg Impurity | <0.50% |
Tag nrho cov impurities | <1.00% |
Test Standard | USP 37 Txuj |
Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo
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Pyrazinamide (CAS: 98-96-4) yog ib hom tshuaj tiv thaiv tuberculosis thib ob.Nws muaj cov tshuaj tua kab mob zoo tiv thaiv tib neeg hom Mycobacterium tuberculosis nrog cov nyhuv bactericidal uas muaj zog tshaj plaws ntawm qhov pH tus nqi ntawm 5-5.5.Nws muaj kev pom zoo tshwj xeeb ntawm cov kab mob bactericidal tawm tsam Mycobacterium tuberculosis hauv cov kab mob phagocytic qeeb qeeb hauv ib puag ncig acidic.Tom qab pyrazinamide nkag mus rau hauv phagocytic hlwb thiab nkag mus rau hauv lub cev ntawm Mycobacterium tuberculosis, lactamases hauv vivo ua rau nws de-amidated, hloov mus rau pyrazine acid los ua cov tshuaj tua kab mob.Pyrazinamide tau tsim nyob rau xyoo 1952, thiab nws yog nitrogen-analog ntawm nicotinamide.Pyrazinamide yog siv kho raws li tus neeg sawv cev antitubercular.Pyrazinamide yog siv los tsim cov polymeric tooj liab complexes, tsim pyrazine carboxamide scaffolds pab tau raws li FXs inhibitors, thiab ua ib feem ntawm cov khoom siv mycobacteria ID.Nws yog siv los kawm txog kev tiv thaiv lub siab toxicity thiab mechanisms ntawm kev tiv thaiv.Pyrazinamide yog ib qho tseem ceeb ntawm cov tshuaj multidrug luv-term kho ntawm tuberculosis.Ua ke nrog isoniazid thiab rifampin, nws ua haujlwm tawm tsam cov kab mob hauv lub cev uas tuaj yeem ua rau rov ua dua.
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