(R)-(+)-2-Methyl-CBS-oxazaborolidine;(R)-Me-CBS Catalyst CAS 112022-83-0 Optical Purity ≥98.0%

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CBS Catalysts
(S)-(-)-2-Methyl-CBS-oxazaborolidine;(S)-Me-CBS Catalyst (ca. 1mol/L hauv Toluene);CAS: 112022-81-8 Nr
(R)-(+)-2-Methyl-CBS-oxazaborolidine;(R)-Me-CBS Catalyst (ca. 1mol/L hauv Toluene);CAS: 112022-83-0 Nr

CBS Catalyst
CBS catalyst lossis Corey-Bakshi-Shibata catalyst yog asymmetric catalyst muab los ntawm proline.Nws pom muaj ntau yam kev siv hauv cov tshuaj organic xws li CBS txo, Diels-Alder cov tshuaj tiv thaiv thiab (3+2) cycloadditions.Proline, ib txwm tshwm sim chiral compound, yog yooj yim thiab pheej yig muaj.Nws hloov nws lub stereocenter mus rau lub catalyst uas nyob rau hauv lem muaj peev xwm tsav ib tug organic tshuaj tiv thaiv xaiv rau ib tug ntawm ob ua tau enantiomers.Qhov kev xaiv no yog vim muaj steric strain nyob rau hauv lub xeev kev hloov pauv uas tsim rau ib qho enantiomer tab sis tsis yog rau lwm tus.

CBS Catalysts rau Asymmetric txo thiab Asymmetric Synthesis
CBS (Corey-Bakshi-Shibata) oxazaborolidine catalyst tau siv rau hauv kev txo qis ntawm prochiral ketones.Lwm daim ntawv thov suav nrog enantioselective synthesis ntawm α-hydroxy acids, α-amino acids, C2-symmetrical ferrocenyl diols, thiab propargyl alcohols.

(R)-(+)-2-Methyl-CBS-oxazaborolidine (ca. 1mol/L hauv Toluene) CAS: 112022-83-0 tuaj yeem siv los ua ib qho catalyst hauv asymmetric borane txo ntawm perfluoroalkyl ketones.Lwm daim ntawv thov muaj xws li enantioselective synthesis ntawm α-hydroxy acids, α-amino acids, C2 symmetrical ferrocenyl diols, thiab propargyl cawv.Nws kuj tseem siv rau hauv kev txo qis desymmetrizing ua rau (S)-4-hydroxycyclohexenone.Nws yog qhov tseem ceeb hauv kev tsim cov stereospecific motifs xws li α-hydroxy acids, α-amino acids, symmetrical ferrocenyl diols thiab propargyl alcohols.

(R)-(+)-2-Methyl-CBS-oxazaborolidine (ca. 1mol/L in Toluene) CAS: 112022-83-0 yog ib qho organoboron catalyst uas yog siv rau hauv cov organic synthesis.Cov catalyst no, tsim los ntawm Itsuno thiab Elias James Corey, yog tsim los ntawm cua sov (R)-(+)-2-(diphenylhydroxymethyl) pyrrolidine nrog rau trimethylboroxine los yog methylboronic acid.Nws yog ib qho cuab yeej zoo heev rau kev sib txuas ntawm cov cawv hauv siab enantiomeric piv.Feem ntau, 2-10 mol% ntawm cov catalyst no yog siv nrog borane-tetrahydrofuran (THF), borane-dimethylsulfide, borane-N, N-diethylaniline, los yog diborane raws li qhov chaw borane.Kev txo qis enantioselective siv chiral oxazaborolidine catalysts tau siv rau hauv kev sib txuas ntawm cov tshuaj lag luam xws li ezetimibe thiab aprepitant.