(R)-(-)-3-Pyrrolidinol Hydrochloride CAS 104706-47-0 Purity ≥99.7% (GC) Chiral Purity ≥99.7% Panipenem thiab Darifenacin hydrobromide Intermediate
Chaw tsim khoom muab khoom;High Purity thiab Competitive Nqe
Shanghai Ruifu Chemical Co., Ltd. Commercial Supply Chiral Compounds:
(R)-(-)-3-Pyrrolidinol Hydrochloride CAS: 104706-47-0
(S)-3-Hydroxypyrrolidine hydrochloride CAS: 122536-94-1
Intermediate ntawm Panipenem (CAS 87726-17-8) thiab Darifenacin hydrobromide (CAS 133099-07-7)
| Tshuaj npe | (R)-(-)-3-Pyrrolidinol Hydrochloride |
| Synonyms | (R)-(-)-3-Hydroxypyrrolidine Hydrochloride;(R)-(-)-3-Hydroxypyrrolidine-HCl |
| CAS Nr | 104706-47-0 |
| CAT Number | Qauv TSIS MUAJ: RF-CC102 |
| Purity / Analysis Method | ≥98.0% (GC) |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
| Molecular Formula | C4H10 NPO |
| Molecular Luj | 123.58 Nws |
| Melting Point | 107.0 ~ 111.0 ° C |
| Solubility hauv dej | Yuav luag Transparency |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Off-White to Pale Brown Crystalline Powder |
| Purity / Analysis Method | ≥99.7% (GC) |
| Chiral Purity | ≥99.7% yog |
| Residue ntawm Ignition | ≤0.50% |
| Kev sib hloov tshwj xeeb [α]D20 | -6.5 ° ~ -8.5 ° (C = 3.5 CH3OH) |
| Txhua tus neeg impurity | ≤ 0.20% |
| Tag nrho impurities | ≤ 0.30% |
| Test Standard | Enterprise Standard |
| Kev siv | Pharmaceutical Intermediates;Chiral Compounds |
Txoj kev tsom xam
Khoom siv: GC ntsuas (Shimadzu GC-2010)
Kem: DB-17 Agilent 30mX0.53mmX1.0μm
Pib qhov cub kub: 80 ℃
Lub sijhawm pib 2.0 min
Tus nqi 15 ℃ / min
Qhov kawg qhov cub kub: 250 ℃
Lub sijhawm kawg 20 min
Carrier gas Nitrogen
Hom Tsis tu ncua
Flow 5.0ml / min
Split ratio 10: 1
Injector kub: 250 ℃
Kev ntsuas kub: 300 ℃
Txhaj ntim 1.0μL
Kev ceev faj yuav tsum tau ua ua ntej kev tshuaj ntsuam:
1. Kab mob ntawm 240 ℃ rau yam tsawg 30 feeb.
2. Ntxuav lub syringe thiab ntxuav cov tshuaj txhaj tshuaj liner kom zoo kom tshem tawm cov kab mob ntawm kev soj ntsuam yav dhau los.
3. Ntxuav, qhuav thiab sau cov diluent nyob rau hauv lub syringe ntxuav vials.
Diluent npaj:
Npaj 2% w / v sodium hydroxide tov hauv dej.
Txuj kev npaj:
Nyhav txog 100mg ntawm (R)-3-hydroxyprrolidine hydrochloride tus qauv rau hauv ib lub vial, ntxiv 1mL ntawm diluent thiab yaj.
Kev npaj xeem:
Ntsuas txog 100mg ntawm cov qauv kuaj rau hauv ib lub vial, ntxiv 1mL ntawm diluent thiab yaj.Npaj nyob rau hauv duplicate.
Txheej txheem:
Txhaj npliag (diluent), kev npaj ua qauv thiab kev sim kev npaj siv saum toj no GC cov xwm txheej.Tsis quav ntsej lub ncov vim qhov khoob.Lub sijhawm khaws cia ntawm lub ncov vim yog (R)-3-hydroxyprrolidine yog li 5.0min.
Nco tseg:
Qhia qhov tshwm sim raws li qhov nruab nrab
Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom thiab cov chaw muag khoom ntawm (R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) nrog cov khoom zoo, dav siv hauv organic synthesis, synthesis ntawm kws tshuaj intermediates thiab Active Pharmaceutical Ingredient (API) synthesis.
(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) yog ib qho nruab nrab feem ntau nyob rau hauv cov synthesis ntawm Panipenem (CAS 87726-17-8) thiab Darifenacin hydrobromide (CAS 133099-07-7).
(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) yog ib qho chiral hydroxy derivative ntawm pyrrlodine siv los npaj cov tshuaj chiral niologically active compounds xws li muscarinic receptor antagonists thiab tshuaj tua kab mob.
Txoj kev ntawm Synthesis ntawm (R)-3-Hydroxypyrrolidine hydrochloride
(R)-4-chloro-3-hydroxybutanitrile tau reacted nrog trimethyl chlorosilane hauv dichloromethane hnyav kom tau txais (R)-4-chloro-3-trimethylsiloxy butanitrile.(R)-4-chloro-3-trimethylsiloxyebutylamine tom qab ntawd hydrogenated ntawm Pd/C catalyst.(R)-3-trimethylsiloxyepyrrolidine tau txais los ntawm sodium hydroxide nplhaib kaw kev kho.Thaum kawg, cov khoom (R)-3-hydroxypyrrolidine hydrochloride tau txais los ntawm kev kho mob hydrochloric acid thiab cov pab pawg tiv thaiv trimethylsilyl raug tshem tawm.
