(R)-(-)-3-Quinuclidinol CAS 25333-42-0 Purity ≥99.0% Chiral Purity ≥99.0%
Tshuaj npe | (R)-(-)-3-Quinuclidinol |
Synonyms | (R)-3-Quinuclinol |
CAS Nr | 25333-42-0 |
CAT Number | Qauv TSIS MUAJ: RF-CC117 |
Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
Molecular Formula | C7H13 Nr |
Molecular Luj | 127.18 Nws |
Hom | Ruifu Tshuaj |
Yam khoom | Specifications |
Qhov tshwm sim | Dawb los yog Off-White hmoov |
Kev txheeb xyuas RT (los ntawm GC) | Ua raws li tus qauv siv |
Melting Point | 212.0 ~ 224.0 ℃ |
Kev sib hloov tshwj xeeb [α]D20 | -40.0° ~ -48.0° |
Moisture (KF) | ≤0.50% |
Residue ntawm Ignition | ≤0.50% |
Purity | ≥99.0% |
Tag nrho cov impurities | ≤ 1.00% |
Chiral Purity | ≥99.0% |
Enantiomer | ≤ 1.00% |
Assay | 98.0% ~ 101.0% (ntawm Anhydrous Basis) |
Test Standard | Enterprise Standard |
Kev siv | Chiral compounds;Pharmaceutical Intermediates |
Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb & noo noo
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom thiab cov chaw muag khoom ntawm (R)-(-)-3-Quinuclidinol (CAS: 25333-42-0) nrog cov khoom zoo, dav siv hauv organic synthesis, synthesis ntawm kws tshuaj intermediates thiab Active Pharmaceutical Ingredient (API) synthesis.(R)-(-)-3-Quinuclidinol tuaj yeem siv los ua ib qho nruab nrab hauv kev sib txuas ntawm API (CAS: 242478-38-2).(CAS: 242478-38-2) yog ib qho tshuaj antimuscarinic uas yog siv los kho lub zais zis ntau dhau ua rau cov tsos mob ntawm zaus, ceev ceev, lossis incontinence.(CAS: 242478-38-2) yog M3 muscarinic receptor antagonist uas tau tsim thiab tsim tawm rau kev kho mob ntawm lub zais zis ntau dhau (pollakiuria) hauv Tebchaws Europe.M3 receptors tau cuam tshuam rau hauv neurally evoked smooth nqaij contractions ntawm lub zais zis, thiab M2 receptors kuj tau xav tias ua si lub luag hauj lwm vim lawv dominance nyob rau hauv lub detrusor nqaij.Lub synthesis ntawm solifenacin koom nrog kev npaj ntawm racemic 1-Phenyl-1,2,3,4-Tetrahydroisoquinoline los ntawm cyclization ntawm N-(2-Phenylethyl) benzamide, thiab tom qab cov tshuaj tiv thaiv nrog ethyl chloroformate thiab transesterification nrog (R)-3-Quinuclidinol .Chiral chromatography them rau qhov kev sib cais ntawm qhov xav tau diastereomer.Xwb, 1-Phenyl-1,2,3,4-Tetrahydroisoquinoline tuaj yeem raug kho qhov muag nrog (+)-Tartaric Acid ua ntej kev kho mob nrog ethyl chloroformate thiab tom qab transesterification.