Ramelteon Intermediate 12 CAS 1053239-39-6 Purity > 98.0% (HPLC)
Cov Chaw Tsim Khoom Ua Lag Luam thiab Chaw Muag Khoom, Intermediates ntawm Ramelteon
Ramelteon (TAK-375) CAS 196597-26-9
2,3-Dihydrobenzofuran CAS 496-16-2
1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-one CAS 196597-78-1
Ramelteon Acrylonitrile CAS 196597-79-2
Despropionyl Ramelteon Hydrochloride CAS 196597-80-5
2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride CAS 1053239-39-6
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| Tshuaj npe | 2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl) ethanamine Hydrochloride |
| Synonyms | Ramelteon Intermediate 12;Ramelteon theem-2 impurity;1,6,7,8-Tetrahydro-2H-Indeno[5,4-B] Furan-8-Ethanamine Hydrochloride |
| CAS Nr | 1053239-39-6 |
| CAT Number | TIAB SA 2887 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
| Molecular Formula | C13H18 NPO |
| Molecular Luj | 239.74 ib |
| Melting Point | 165.0 ~ 167.0 ℃ |
| Qhov ntom | 1.058 ± 0.06 g / cm3 |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Dawb rau Off-White Solid Powder |
| Purity / Analysis Method | > 98.0% (HPLC) |
| Poob rau ziab | <1.00% |
| Ib leeg Impurity | <1.00% |
| Tag nrho cov impurities | <2.00% |
| 1 H NMR Spectrum | Raws li tus qauv |
| Test Standard | Enterprise Standard |
| Kev siv | Intermediate of Ramelteon (CAS: 196597-26-9) |
Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride (CAS: 1053239-39-6) yog ib qho nruab nrab ntawm Ramelteon (CAS: 196597- 26–9).Tsis zoo li feem ntau cov kev kho mob ntawm insomnia uas tsom rau GABA (g-aminobutyric acid) receptor complex, Ramelteon yog ib qho agonist ntawm melatonin receptor.Tshwj xeeb, nws muaj kev xaiv siab rau MT1 thiab MT2 subtypes, uas tau cuam tshuam rau kev saib xyuas ntawm circadian rhythms, dhau ntawm MT3 receptor lub luag haujlwm rau lwm yam melatonin zog.Nws tsis muaj kev sib raug zoo rau tsis yog GABA receptor complex tab sis kuj neurotransmitter, dopaminerigic, opiate, thiab benzodiazepine receptors qhia txog kev txhim kho kev ruaj ntseg profile tsis muaj kev tsim txom ntawm cov tshuaj hypnotic uas tsom cov receptors.Raws li xws li, Ramelteon tsis yog cov tshuaj teem sijhawm.Lub hauv paus metabolites suav nrog hydroxylation thiab oxidation rau carbonyl hom nrog cov metabolites thib ob uas ua los ntawm glucuronidation.Txij li thaum CYP1A2 yog cov isozyme loj koom nrog hauv cov metabolism hauv lub siab ntawm Ramelteon, nws yuav tsum tsis txhob noj nrog CYP1A2 inhibitors muaj zog, xws li fluvoxamine.Kev sib koom ua ke nrog ketoconazole (ib CYP3A4 inhibitor) lossis fluconazole (lub zog CYP2C9 inhibitor) ua rau muaj kev nce ntxiv hauv AUC thiab Cmax, tab sis cov metabolism hauv qhov dav thiab qhov sib txawv ntawm cov ntshav plasma ntau ntawm Ramelteon tau txwv tsis pub hloov pauv koob tshuaj.Lub pob ntxig, txawm li cas los xij, ceeb toom cov neeg mob txog kev sib koom ua ke nrog cov muaj zog CYP3A4 thiab CYP2C9 inhibitors.Raws li qhov tshwm sim ntawm kev sim tshuaj, qhov pom zoo koob tshuaj ntawm Ramelteon yog 8mg noj nyob rau hauv 30 min ntawm kev mus pw.Ntxiv nrog rau kev ceev faj ntawm kev sib koom ua ke nrog CYP inhibitors, nws yuav tsum tsis txhob siv rau hauv cov neeg mob uas muaj lub siab tsis zoo.Cov xwm txheej tsis zoo, pom hauv 5% ntawm cov neeg mob hauv kev tshawb fawb soj ntsuam, yog somnolence, kiv taub hau, xeev siab, nkees, mob taub hau, thiab insomnia.
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