Rapamycin Sirolimus RAPA CAS 53123-88-9 Assay ≥98.5% API Hoobkas High Purity
Chaw tsim tshuaj paus nrog High Purity thiab ruaj khov zoo
Lub npe tshuaj: Rapamycin;Sirolimus;RAPA
CAS: 53123-88-9 Nr
Macrolide Immunosuppressive Agent
API High Quality, Commercial Production
Tshuaj npe | Rapamycin |
Synonyms | Sirolimus;RAPA;TIAB SA - 22989 |
CAS Nr | 53123-88-9 |
CAT Number | RF-API 59 |
Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale nce mus txog pua pua ntawm Kilograms |
Molecular Formula | C51H79NO13 |
Molecular Luj | 9 14.19 |
Melting Point | 183.0 ~ 185.0 ℃ |
Hom | Ruifu Tshuaj |
Yam khoom | Specifications |
Qhov tshwm sim | Dawb los yog Off-White Crystalline Hmoov |
Kev Taw Qhia A | IR spectrum ntawm poov tshuaj bromide npaj ntawm cov qauv qhia maxima ntawm tib lub wavelengths raws li qhov zoo sib xws ntawm kev npaj hauv tsev siv tus qauv |
Kev Qhia B | UV spectrum ntawm 95% ethanol npaj ntawm cov qauv nthuav tawm maxima ntawm 267nm, 277nm, 288nm raws li qhov kev npaj zoo sib xws ntawm cov qauv siv hauv tsev |
Kev txheeb xyuas C | Lub sijhawm khaws cia ntawm qhov siab tshaj plaws rau cov trans-thiab cis-stereoisomers hauv chromatogram ntawm kev tshuaj ntsuam kev npaj sib raug rau qhov hauv chromatogram ntawm tus qauv npaj, raws li tau txais hauv qhov kev xeem. |
Kev hloov kho qhov muag | -147.0° ~ -157.0° |
Poob rau ziab | ≤0.50% |
Residue ntawm Ignition | ≤ 0.20% |
Hnyav Hlau | ≤ 20ppm |
Tus kheej impurity | ≤ 1.5% |
Tag nrho cov impurities | ≤2.0% (tsis suav Cis-Stereoisomer ntawm Sirolimus) |
Cis-Stereoisomer ntawm Sirolimus | ≤ 5.0% |
Residual Solvents | |
Ethanol | ≤5000ppm |
Ethyl Acetate | ≤5000ppm |
Cyclhexane | ≤5000ppm |
Acetone | ≤5000ppm |
Diethyl Ether | ≤5000ppm |
Assay | ≥98.5% (Xam cov trans- thiab cis-stereoisomer ntawm sirolimus ntawm lub hauv paus tsis txaus ntseeg) |
Test Standard | Suav Pharmacopoeia (CP);Enterprise Standard |
Kev siv | Active Pharmaceutical Ingredients (API) |
Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.
Rapamycin (Sirolimus; AY 22989) yog ib qho autophagy activator, ib daim ntawv tshiab ntawm macrolide immunosuppressive tus neeg saib xyuas nrog zoo curative teebmeem, tsis tshua muaj toxicity, thiab tsis muaj nephrotoxicity.Nws tuaj yeem siv los tswj kev tiv thaiv kab mob hauv lub cev (tshwj xeeb tshaj yog nyob rau hauv lub raum hloov pauv) kom txo qis kev tiv thaiv kab mob tom qab kev phais mob.