Remdesivir GS-5734 CAS 1809249-37-3 COVID-19 API Zoo
Chaw tsim tshuaj paus kev lag luam muab Remdesivir thiab cuam tshuam nrog cov khoom zoo
Remdesivir CAS 1809249-37-3
2-Ethyl-1-butanol CAS 97-95-0
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4-Nitrophenol CAS 100-02-7
2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate CAS 1911578-98-7
N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-Alanine 2-ethylbutyl ester CAS 1354823-36-1
(S)-2-Ethylbutyl 2-Aminopropanoate Hydrochloride CAS 946511-97-3
Remdesivir Metabolite (GS-441524) CAS 1191237-69-0
Remdesivir N-2 Intermediate CAS 1191237-80-5
Tom ntej: 2,3,5-Tri-O-benzyl-D-ribonolactone CAS 55094-52-5
7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine CAS 937046-98-5
Pyrrolo[1,2-F][1,2,4]Triazin-4-Amine CAS 159326-68-8
4-Amino-7-iodopyrrolo[2,1-f][1,2,4]triazine CAS 1770840-43-1
Tshuaj npe | Remdesivir |
Synonyms | GS-5734;2-ethylbutyl ((S)-((((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano 3,4-dihydroxytetrahydrofuran-2-yl)methoxy) (phenoxy) phosphoryl) -L-alaninate |
CAS Nr | 1809249-37-3 |
CAT Number | RF-API 96 |
Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale nce mus txog pua pua ntawm Kilograms |
Molecular Formula | C27H35N6O8P |
Molecular Luj | 602.58 ib |
Qhov ntom | 1.47 ± 0.1g / cm3 |
Hom | Ruifu Tshuaj |
Yam khoom | Specifications |
Qhov tshwm sim | Dawb rau Off-White Solid Powder |
Kev Taw Qhia A | IR: Infrared absorption spectrum ntawm cov khoom yuav tsum ua raws li cov khoom siv |
Kev Qhia B | HPLC Lub sijhawm khaws cia zoo ib yam li cov khoom siv |
Kev sib hloov tshwj xeeb | -19.0 ° ~ -22.0 ° C |
Solubility | Soluble hauv Methanol, Sparingly Soluble hauv Ethanol, Me ntsis Soluble hauv Acetonitrile, Xyaum Insoluble hauv dej |
Yam khoom muaj feem | |
Txhua tus neeg impurity | ≤0.10% |
Tag nrho cov impurities | ≤ 1.0% |
RD-3.1 | ≤0.10% |
RD-C | ≤0.10% |
RD-D | ≤0.10% |
RD-E | ≤0.10% |
RP-Isomer | ≤0.10% |
Nitrophenol | ≤0.10% |
Residual Solvents | |
Methanol Dichloride | ≤6000ppm |
Acetone | ≤5000ppm |
Isopropyl cawv | ≤5000ppm |
Cov tshuaj acetonitrile | ≤410ppm |
Dichloromethane | ≤600ppm |
Methyl tert Butyl Ether hmoov | ≤5000ppm |
Ethyl Acetate | ≤5000ppm |
Tetrahydrofuran | ≤720ppm |
n-Heptane | ≤5000ppm |
Assay | 98.0% ~ 102.0% (Xau ntawm lub hauv paus qhuav) |
Tag nrho Aerobic suav | |
Cov kab mob aerobic | ≤100cfu / g |
Poov thiab Pwm | ≤10cfu/g |
E. Coil | Tsis zoo |
Cov kab mob endotoxin | ≤1.0EU |
Hnyav Hlau | ≤ 20ppm |
Test Standard | Enterprise Standard |
Kev siv | API, COVID-19 |
Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.
Remdesivir (CAS 1809249-37-3), muag raws li lub npe Veklury, yog cov tshuaj tiv thaiv kab mob dav dav tsim los ntawm lub tuam txhab biopharmaceutical Gilead Sciences.Nws yog siv los ntawm kev txhaj tshuaj rau hauv cov hlab ntsha.Thaum lub sij hawm tus kab mob COVID-19 muaj thoob qhov txhia chaw, remdesivir tau pom zoo los yog tso cai siv thaum muaj xwm ceev los kho COVID-19 nyob ib ncig ntawm 50 lub teb chaws.Hloov kho cov lus qhia los ntawm Lub Koom Haum Saib Xyuas Kev Noj Qab Haus Huv Hauv Ntiaj Teb thaum Lub Kaum Ib Hlis 2020 suav nrog cov lus pom zoo rau kev siv Remdesivir rau kev kho mob ntawm COVID-19.Remdesivir yog thawj zaug tsim los kho kab mob siab C, thiab tom qab ntawd tau tshawb fawb txog tus kab mob Ebola thiab Marburg tus kab mob ua ntej tau kawm raws li kev kho mob tom qab kis rau COVID-19.Cov kev mob tshwm sim feem ntau hauv cov neeg tuaj yeem noj qab haus huv yog nce qib ntshav ntawm daim siab enzymes (ib qho cim qhia ntawm lub siab teeb meem).Cov kev mob tshwm sim feem ntau hauv cov neeg muaj COVID-19 yog xeev siab.Cov kev mob tshwm sim tuaj yeem muaj xws li daim siab mob thiab cov tshuaj tiv thaiv kab mob ntsig txog xeev siab, ntshav siab, thiab tawm hws.Remdesivir yog ib qho tshuaj uas tsim los tso cai rau kev xa tawm hauv lub cev ntawm GS-441524 monophosphate thiab tom qab biotransformation rau GS-441524 triphosphate, ribonucleotide analogue inhibitor ntawm viral RNA polymerase.