Sorafenib Tosylate CAS 475207-59-1 Purity ≥99.0% (HPLC) API Hoobkas Zoo
Kev Lag Luam Kev Lag Luam Sorafenib Tosylate thiab Cov Neeg Nruab Nrab cuam tshuam:
Sorafenib Tosylate CAS: 475207-59-1
Sorafenib CAS: 284461-73-0
4-Chloro-N-Methyl-2-Pyridinecarboxamide CAS: 220000-87-3
4-(4-Aminophenoxy)-N-Methylpicolinamide CAS NO: 284462-37-9
4-Chloro-3-(Trifluoromethyl) phenyl Isocyanate CAS: 327-78-6
| Tshuaj npe | Sorafenib Tosylate |
| Synonyms | Nexavar;4-[4-[3-[4-Chloro-3-(Trifluoromethyl)phenyl]ureido]phenoxy]-N-Methylpicolinamide 4-Methylbenzenesulfonate;4-[4-[[4-Chloro-3-(Trifluoromethyl)phenyl]carbamamido]phenoxy]-N-Methyl-2-Pyridinecarboxamide 4-Methylbenzenesulfonate;BAY 43-9006 Tosylate |
| CAS Nr | 475207-59-1 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale nce mus txog pua pua ntawm Kilograms |
| Molecular Formula | C21H16ClF3N4O3.C7H8O3S |
| Molecular Luj | 637.03 ib |
| Melting Point | 225.0 txog 230.0 ℃ |
| rhiab heev | Cua Sensitive, Thaum tshav kub kub Sensitive |
| Solubility | Soluble hauv dej (<1 mg / ml) ntawm 25 ℃, DMSO (127 mg / ml) ntawm 25 ℃, thiab Ethanol (<1 mg / ml) ntawm 25 ℃ |
| Cov xwm txheej shipping | Txias & qhuav qhov chaw (2 ~ 8 ℃), Tiv thaiv los ntawm lub teeb |
| COA & MSDS | Muaj |
| Txee lub neej | 2 Xyoo yog khaws cia kom raug |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications | Cov txiaj ntsig |
| Qhov tshwm sim | Lub teeb daj lossis dawb hmoov | Ua raws |
| Purity / Analysis Method | ≥99.0% (HPLC) | 99.8% |
| Melting Point | 225.0 ~ 230.0 ℃ | Ua raws |
| Hnyav Hlau | ≤10ppm | <10ppm |
| Poob rau ziab | ≤0.50% | 0.12% |
| Residue ntawm Ignition | ≤ 0.20% | 0.10% |
| Ib qho Impurity | ≤0.50% | Ua raws |
| Tag nrho cov impurities | ≤0.50% | Ua raws |
| NMR Spectrum | Raws li tus qauv | Ua raws |
| Test Standard | Enterprise Standard | Ua raws |
| Kev siv | Sorafenib Tosylate (CAS: 475207-59-1) hauv kev kho RCC & HCC | |
Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv lub thawv kaw nruj nreem.Khaws rau hauv qhov chaw txias, qhuav (2 ~ 8 ℃) thiab lub tsev tso cua txias kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.
Risk Codes 36/37/38 - Irritating rau qhov muag, ua pa thiab tawv nqaij.
Kev Nyab Xeeb Kev Nyab Xeeb S28 - Tom qab sib cuag nrog daim tawv nqaij, ntxuav tam sim nrog xab npum-suds ntau.
S26 - Nyob rau hauv rooj plaub ntawm qhov muag, yaug tam sim ntawd nrog dej txaus thiab nrhiav kev kho mob.
Sorafenib Tosylate (CAS: 475207-59-1) yog ib yam tshiab ntawm ntau lub hom phiaj tshuaj tiv thaiv kab mob, tau tsim los ntawm German Bayer Pharmaceuticals, thiab nthuav tawm cov kev ua ub no nthuav dav hauv kev kuaj tsiaj ua ntej.Sorafenib muaj nyob rau hauv 200-mg ntsiav tshuaj rau kev tswj qhov ncauj thiab siv rau hauv kev kho mob ntawm RCC thiab HCC.Sorafenib Tosylate tuaj yeem cuam tshuam rau cov qog nqaij hlav thiab qog cov hlab ntsha.Nws muaj cov nyhuv antitumor ob npaug: nws tuaj yeem thaiv lub xov tooj ntawm tes teeb liab txoj hauv kev sib kho los ntawm RAF / MEK / ERK kom ncaj qha inhibit qog cell loj hlob, thaum tseem inhibiting VEGF thiab platelet derived growth factors (PDGF) receptors los tiv thaiv kev tsim cov qog ntshav tshiab. cov hlab ntsha, yog li indirectly inhibiting qog cell loj hlob.
Sorafenib Tosylate, lub npe lag luam Nexavar, nws yog thawj zaug tsim los ntawm Bayer Pharmaceuticals hauv Tebchaws Yelemees.Sorafenib Tosylate yog ib tug multi-kinase inhibitor uas yuav siv tau los kho cov kab mob xws li mob qog noj ntshav.Thaum Lub Kaum Ob Hlis 2005, nws tau pom zoo los ntawm US FDA ua cov tshuaj thawj zaug rau kev kho mob qog noj ntshav siab.Thaum Lub Yim Hli 2009, nws tau raug teev npe hauv Suav teb nrog kev pom zoo los ntawm Lub Xeev Lub Chaw Tswj Xyuas Khoom Noj thiab Tshuaj.
Sorafenib Tosylate yog tyrosine kinases (VEGFR thiab PDGFR) thiab RAF / MEK / ERK cascade inhibitors, ua haujlwm ib txhij ntawm Raf-1, wtBRAF thiab V599EBRAF, nrog IC50 ntawm 6 nM, 22 nM thiab 38 nM, feem.
Sorafenib Tosylate tuaj yeem cuam tshuam ntau yam kinases uas muaj nyob rau ntawm lub xovtooj ntawm tes thiab lub xovtooj ntawm tes, suav nrog RAF kinase, vascular endothelial growth factor-2 (VEGFR-2), vascular endothelial growth factor receptor-3 (VEGFR-3), platelet. -derived kev loj hlob receptor-β (PDGFR-β), KIT thiab FLT-3.Nws tuaj yeem pom tias sorafenib toluenesulfonate muaj ob txoj kev tiv thaiv qog.Ntawm ib sab, nws tuaj yeem cuam tshuam cov qog loj hlob ncaj qha los ntawm inhibiting RAF / MEK / ERK txoj kev taw qhia;Ntawm qhov tod tes, nws tuaj yeem cuam tshuam VEGFR thiab PDGFR.Thiab thaiv kev tsim ntawm qog neovascularization, indirectly inhibit qhov kev loj hlob ntawm qog hlwb.Sorafenib Tosylate yog tam sim no cov tshuaj zoo tshaj plaws rau kev kho mob qog noj ntshav siab los ntawm kev tswj hwm lub cev, thiab yuav zoo li yuav dhau los ua cov tshuaj tshiab rau kev kho tus kab mob no.
Sorafenib Tosylate ib hnub ib zaug kev tswj hwm qhov ncauj ntawm tib neeg qog nqaij hlav tsiaj hloov cov qauv qhia ntau yam kev tiv thaiv qog noj ntshav, suav nrog mob qog noj ntshav, tsis yog cell carcinoma, mob qog noj ntshav mis, melanoma, mob qog nqaij hlav pancreatic, leukemia thiab qog noj ntshav ntawm zes qe menyuam thiab nas lub raum cell carcinoma. qauv, RENCA qauv.
