Tacrolimus FK-506 Fujimycin CAS 104987-11-3 API Hoobkas High Purity
Chaw tsim tshuaj paus nrog High Purity thiab ruaj khov zoo
Lub npe tshuaj: Tacrolimus
Lub ntsiab lus: FK-506;Fujimycin
CAS: 104987-11-3 Nr
API, Siab Zoo, Kev Lag Luam Ntau Lawm
Tshuaj npe | Tacrolimus |
Synonyms | FK-506;Fujimycin |
CAS Nr | 104987-11-3 |
CAT Number | RF-API 46 |
Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
Molecular Formula | C44H69NO12 |
Molecular Luj | 804.02 ib |
Hom | Ruifu Tshuaj |
Yam khoom | Specifications |
Qhov tshwm sim | Tawm-dawb los yog daj daj daj hmoov zoo, tsis muaj ntxhiab tsw, tshwj xeeb qab zib |
Kev txheeb xyuas | Yuav tsum muaj kev pom zoo |
Qhov tseeb | Ua raws li tus qauv |
pH | 5.0 ~ 6.0 |
Chloride | ≤ 0.014% |
Sulfate | ≤ 0.029% |
Heavy Metals (Pb) | ≤10ppm |
Arsenic | ≤ 0.0002% |
Moisture (KF) | ≤8.0% |
Residue ntawm Ignition | 18.0% ~ 22.0%. |
Assay | ≥72.0% (HPLC, ntawm lub hauv paus qhuav) |
Test Standard | Enterprise Standard |
Kev siv | API |
Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.
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Tacrolimus (tseem FK-506 los yog Fujimycin) yog ib qho tshuaj tiv thaiv kab mob uas nws lub ntsiab siv yog tom qab hloov cov khoom nruab nrog los txo cov kev ua haujlwm ntawm tus neeg mob lub cev tiv thaiv kab mob thiab yog li muaj kev pheej hmoo ntawm kev tsis lees paub lub cev.Nws kuj yog siv rau hauv cov tshuaj pleev ib ce nyob rau hauv kev kho mob ntawm atopic dermatitis, hnyav refractory uveitis tom qab hloov pob txha pob txha, thiab cov tawv nqaij mob vitiligo.Tacrolimus yog thawj zaug muab rho tawm los ntawm fermentation broth ntawm Streptomyces tsukuba, av microbe pom nyob rau hauv Tsukuba, Nyiv.Lub npe tacrolimus yog muab los ntawm kev noj 't' rau Tsukuba, lub npe ntawm lub roob uas cov qauv av tau muab rho tawm, 'acrol' rau macrolide thiab 'imus' rau kev tiv thaiv kab mob.Txawm hais tias cov txheej txheem tsis cuam tshuam rau cyclosporin, tacrolimus qhia tau hais tias zoo ib yam ntawm cov tshuaj tiv thaiv kab mob rau tus neeg sawv cev ntawm qib cellular thiab molecular.Cov kev tshawb fawb pib qhia tau hais tias tacrolimus yog ib qho tshuaj tiv thaiv kab mob muaj zog, uas qhia txog kwv yees li 100-fold ntau dua hauv vitro potency tshaj cyclosporin hauv inhibiting T cell activation.Tom qab hauv vivo cov kev tshawb fawb tau pom tias tacrolimus ua tau zoo ob qho tib si hauv kev tiv thaiv tus kheej thiab kev sim kab mob autoimmune, thiab tiv thaiv allograft thiab xenograft tsis lees paub hauv cov tsiaj qauv ntawm kev hloov pauv hauv nruab nrog cev.Thaum pib, tacrolimus tau siv rau kev tiv thaiv kab mob ntawm cov neeg mob uas tau txais kev hloov pauv ntawm allograft kom txwv tsis pub lawv tsis lees txais lawv cov grafts tshiab.Tsis ntev, txawm li cas los xij, los ntawm cov txiaj ntsig ntawm kev tshawb fawb zoo, nws tau pom tias tacrolimus tuaj yeem ua rau muaj txiaj ntsig zoo hauv cov tawv nqaij tsis zoo hauv qee tus neeg mob uas tau hloov pauv.Qhov kev tshawb pom ntawm tacrolimus tau ua rau muaj kev nkag siab ntau dua ntawm daim tawv nqaij pathology, piv txwv li atopic dermatitis.Tom qab ntawd, lwm yam kev siv tshuaj pleev ib ce ntawm tacrolimus tau tshaj tawm thiab kev siv tus neeg sawv cev no hauv dermatology yog maj mam nthuav dav.
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