Tenofovir Disoproxil Fumarate CAS 202138-50-9 Assay 98.0% ~ 102.0% API Hoobkas
Kev muag khoom lag luam Tenofovir Related Intermediates:
Tenofovir CAS: 147127-20-6
Tenofovir Disoproxil Fumarate CAS 202138-50-9
Tenofovir Alafenamide Hemifumarate CAS 1392275-56-7
Tom ntej: Chloromethyl Isopropyl Carbonate CAS 35180-01-9
Diethyl (p-Toluenesulfonyloxymethyl) phosphonate CAS 31618-90-3
(R)-(+)-Propylene Carbonate CAS 16606-55-6
(R)-9-(2-Hydroxypropyl)adenine CAS 14047-28-0
Diethyl (Hydroxymethyl) phosphonate CAS 3084-40-0
Adenine CAS 73-24-5
Tshuaj npe | Tenofovir Disoproxil Fumarate |
Synonyms | Tenofovir DF;Bis (POC)-PMPA Fumarate;GS4331 Fumarate |
CAS Nr | 202138-50-9 |
CAT Number | RF-API 106 |
Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
Molecular Formula | C23H34N5O14P |
Molecular Luj | 635.52 ib |
Melting Point | 113.0 txog 115.0 ℃ |
Hom | Ruifu Tshuaj |
Yam khoom | Specifications |
Qhov tshwm sim | Dawb los yog Yuav luag Dawb Hmoov |
Kev Taw Qhia A | IR Spectrum Conforms rau Reference Standard |
Kev Qhia B | Lub sijhawm khaws cia ntawm lub ncov loj los ntawm cov qauv kev daws teeb meem sib raug rau qhov kev daws teeb meem, raws li tau txais hauv qhov kev sim |
Assay | 98.0% ~ 102.0% (raws li anhydrous hauv paus) |
Dej | ≤ 1.0% |
Fumaric Acid | 17.5% ~ 19.0%. |
Residue ntawm Ignition | ≤ 0.20% |
Hnyav Hlau | ≤ 20ppm |
Chloromethyl Isopropyl Carbonate | ≤ 0.15% |
Yam khoom muaj feem | |
Tenofovir | ≤ 0.15% |
Adenine | ≤ 0.15% |
Tenofovir Isoproxi Monoester | ≤ 1.0% |
Tenofovir Disoproxil Ethyl Ester | ≤ 0.15% |
Tenofovir Isopropyl Isoproxil | ≤ 0.30% |
Tenofovir Disoproxil Carbamate | ≤ 0.15% |
Tenofovir Disproxil | ≤ 0.15% |
Ib qho Impurity | ≤0.10% |
Tag nrho cov impurities | ≤ 2.0% |
Test Standard | Enterprise Standard |
Kev siv | API |
Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo.
Tenofovir Disoproxil Fumarate (CAS: 202138-50-9), ib tug prodrug ntawm tenofovir (Lub npe lag luam: Viread) tsim los ntawm Gilead Sciences, yog ib hom ntawm nucleotide-analogues antiretroviral tshuaj, noj cov nyhuv los ntawm kev ua raws li cov reverse transcriptase inhibitors [nRTIs] , uas thaiv kev thim rov qab transcriptase, ib qho enzyme tseem ceeb rau kev tsim cov kab mob hauv cov neeg mob HIV.Nws yuav tsum raug sau tseg tias nws yog thawj nucleotide thim rov qab transcriptase inhibitor uas tau siv los kho tus kab mob HIV.Tenofovir Disoproxil Fumarate hloov mus rau tenofovir hauv vivo, uas yog acyclic nucleoside phosphonate [nucleotide] analog ntawm adenosine 5'-monophosphate.Nws feem ntau yog siv ua ke nrog lwm yam tshuaj.Cov tshuaj HIV tsis tuaj yeem kho HIV / AIDS, tab sis kev noj cov tshuaj HIV sib xyaw ua ke [hu ua kab mob HIV] txhua hnub tuaj yeem pab cov neeg mob HIV muaj sia nyob ntev, noj qab nyob zoo.Raws li FDA cov ntaub ntawv, tenofovir disoproxil fumarate kuj tuaj yeem yog rau kev kho mob ntawm tus kab mob siab B mob ntev [HBV] kab mob rau cov neeg laus thiab menyuam yaus hnub nyoog 12 xyoos thiab laus dua.