Tom ntej: Tolvaptan CAS 150683-30-0 API Purity > 99.0% (HPLC)
Chaw tsim tshuaj paus Supply Tolvaptan thiab Related Intermediates:
Tolvaptan CAS 150683-30-0
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one CAS 160129-45-3
o-Toluoyl Chloride CAS 933-88-0
Tom ntej: 4-Amino-2-Methylbenzoic Acid CAS 2486-75-1
Tom ntej: 2-Methyl-4-Nitrobenzoic Acid CAS 1975-51-5
| Lub npe | Tolvaptan |
| Tshuaj npe | N-[4-(9-chloro-6-hydroxy-2-azabicyclo[5.4.0]undeca-8,10,12-triene-2-carbonyl)-3-methyl-phenyl]-2-methyl-benzamide |
| CAS Nr | 150683-30-0 |
| CAT Number | RF-API 101 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
| Molecular Formula | C26H25ClN2O3 |
| Molecular Luj | 448.94 ib |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Dawb rau Off-White Crystalline Hmoov |
| Cov txheej txheem qhia | IR, HPLC |
| Solubility | Soluble nyob rau hauv Benzyl Cawv thiab Methanol tab sis xyaum Insoluble hauv dej thiab Hexane |
| Purity / Analysis Method | > 99.0% (HPLC) |
| Melting Point | 219.0 ~ 222.0 ℃ |
| Poob rau ziab | <0.50% |
| Residue ntawm Ignition | <0.10% |
| Ib leeg Impurity | <0.50% |
| Tag nrho cov impurities | <1.00% |
| Hnyav Hlau | ≤ 20ppm |
| Residual Solvents | Ua raws li Specification |
| Test Standard | Enterprise Standard |
| Kev siv | API;Pharmaceutical Intermediates |
Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo
Tolvaptan (CAS: 150683-30-0), tseem hu ua OPC-41061, yog ib qho kev xaiv, kev sib tw arginine vasopressin receptor 2 antagonist siv los kho hyponatremia (cov ntshav qis qis) cuam tshuam nrog lub plawv tsis ua hauj lwm, cirrhosis, thiab cov tsos mob ntawm Cov tshuaj tiv thaiv kab mob tsis tsim nyog (SIADH).Otsuka Pharmaceutical muaj ntawv tso cai tolvaptan nyob rau hauv lub npe lag luam Samsca tom qab FDA pom zoo cov tshuaj nyob rau lub Tsib Hlis 2009. Tolvaptan kuj tau pom tias muaj txiaj ntsig tiv thaiv kab mob polycystic raum.Hauv kev sim xyoo 2004, tolvaptan tau muab tshuaj nrog cov tshuaj diuretics tau sau tseg kom ua kom cov kua dej ntau ntxiv thiab txhim kho cov ntshav sodium hauv cov neeg mob plawv tsis ua haujlwm yam tsis muaj kev phiv xws li hypotension (tsis tshua muaj ntshav siab) lossis hypokalemia (cov ntshav qis ntawm cov poov tshuaj).Cov tshuaj kuj pom tias tsis muaj kev cuam tshuam rau lub raum ua haujlwm.
![7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one CAS 160129-45-3 Tolvaptan Intermediate](https://www.ruifuchemical.com/uploads/7-Chloro-1234-tetrahydrobenzobazepin-5-one-CAS-160129-45-3-300x300.jpg)
