Trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7 Purity > 98.0% (HPLC) Afatinib Dimaleate Intermediate

Lus piav qhia luv luv:

Trans-4-Dimethylaminocrotonic Acid Hydrochloride

CAS: 848133-35-7 Nr

Purity:> 98.0% (HPLC)

Tshwm Sim: Dawb rau Yuav luag Dawb Hmoov

Intermediate of Afatinib Dimaleate (CAS: 850140-73-7)

Hu rau: Dr. Alvin Huang

Txawb/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Product Detail

Yam khoom

Khoom cim npe

Nqe lus piav qhia:

Ruifu Chemical Supply Intermediates ntawm Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
Tom ntej: Dimethylamino Acetaldehyde Diethyl Acetal CAS 3616-56-6
Tom ntej: Trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-ib CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS Nr .: 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS Nr .: 314771-88-5

Chemical Properties:

Tshuaj npe	Trans-4-Dimethylaminocrotonic Acid Hydrochloride
Synonyms	trans 4-Dimethylaminocrotonic Acid HCl;(E)-4-(Dimethylamino)-2-Butenoic Acid Hydrochloride;(E)-4-Dimethylaminocrotonic Acid Hydrochloride;(2E)-4-(Dimethylamino)tab sis-2-Enoic Acid Hydrochloride;Afatinib int-2
CAS Nr	848133-35-7
Tshuag xwm txheej	Hauv Tshuag, Kev Lag Luam Loj
Molecular Formula	C6H12ClNO2
Molecular Luj	165.62 ib
rhiab heev	Hygroscopic.Moisture Sensitive
Melting Point	160.0 txog 164.0 ℃
Solubility	DMSO (me ntsis), Methanol (me ntsis), Dej (me ntsis)
COA & MSDS	Muaj
Keeb kwm	Shanghai, Suav
Hom	Ruifu Tshuaj

Specifications:

Yam khoom	Specifications
Qhov tshwm sim	Dawb rau Yuav luag Dawb Hmoov
Purity / Analysis Method	> 98.0% (HPLC)
Purity / Analysis Method	> 98.0% (NMR)
Moisture (KF)	<0.50%
Residue ntawm Ignition	<0.20%
Ib leeg Impurity	<0.50%
Heavy Metals (raws li Pb)	<20 ppm
Infrared Spectrum	Raws li tus qauv
1 H NMR Spectrum	Proton NMR Spectrum
Test Standard	Enterprise Standard
Kev siv	Intermediate ntawm Afatinib, Afatinib Dimaleate

Pob & Cia:

Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.

Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo.

Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.

Chromatographic Purity:

Khoom siv: Agilent 1200 HPLC HPLC chromatograph, DAD detector.
Kem: Agilent XDB-C18,250 * 4.6mm, 5μm
Txawb theem: B: 1.95g sodium octane sulfonate + 8ml phosphoric acid + 5ml triethylamine + 500ml dej
C: acetonitrile
Kev npaj ntawm kev sib xyaw mobile theem: noj 400ml B tov thiab 100ml acetonitrile, sib tov kom huv si thiab sib npaug, thiab tso cov kua hauv ib theem.
Tus nqi ntws: 0.5ml / min54bar
Kem kub: 25 ℃
Lub wavelength: 210nm
Cov qauv kev daws teeb meem: txawb theem tau siv los ua hnyav, cov qauv khoom: 0.0040g / 2ml, qauv loj 2.0μl.

Qhov zoo:

FAQ:

Daim ntawv thov:

trans-4-Dimethylaminocrotonic Acid Hydrochloride (CAS: 848133-35-7) yog ib qho reagent siv los npaj tyrosine kinase inhibiting antitumor agents.trans-4-Dimethylaminocrotonic Acid Hydrochloride tuaj yeem siv los ua ib qho nruab nrab ntawm Afatinib (CAS: 439081-18-2), Afatinib Dimaleate (CAS: 850140-73-7), Neratinib (CAS: 698387-09-6).Afatinib yog ib qho tshuaj pom zoo rau kev kho mob uas tsis yog mob ntsws me me (NSCLC), tsim los ntawm Boehringer Ingelheim.Nws ua raws li angiokinase inhibitor.Zoo li Lapatinib thiab Neratinib, Afatinib yog tyrosine kinase inhibitor (TKI) uas tseem cuam tshuam tsis zoo rau tib neeg epidermal kev loj hlob receptor 2 (Her2) thiab epidermal growth factor receptor (EGFR) kinases.Afatinib tsis tsuas yog tawm tsam EGFRKev hloov pauv tau tsom los ntawm thawj tiam TKIs likeerlotinib lossis gefitinib, tab sis kuj tawm tsam cov tsis nkag siab rau cov qauv kev kho no.Vim tias nws cov haujlwm ntxiv tawm tsam Her2, nws tau raug tshuaj xyuas mob qog noj ntshav nrog rau lwm yam EGFR thiab Her2 uas tau tsav cov qog noj ntshav.Neratinib tsim los ntawm US Wyeth tuam txhab yog ib qho irreversible epidermal loj hlob yam receptor (EGFR) inhibitor.Nws yog ntau lub hom phiaj ntawm cov molecule tyrosine kinase inhibitors rau HER 2 thiab HER1 tom qab Lapatinib, thiab yog ib qho irreversible ErbB receptor tyrosine kinase inhibitor.Neratinib tuaj yeem xaiv inhibit HER-1 thiab HER-2 ntawm EGFR tsev neeg (IC50 yog 92 nmol / L thiab 59 nmol / L, feem).Kev tshawb fawb soj ntsuam tau pom tias Neratinib tau siv tshuaj kho mob tseem ceeb ntawm cov qog nqaij hlav qog nqaij hlav tsis me me, mob qog noj ntshav, thiab mob qog noj ntshav.Theem Ⅱ kev sim tshuaj ntsuam xyuas tau qhia tias Neratinib tau pom tias muaj txiaj ntsig zoo thiab ua siab ntev rau HER-2 cov neeg mob zoo nrog mob qog noj ntshav siab uas tau txais lossis tsis kho Trastuzumab.Theem Ⅲ kev kuaj mob qog noj ntshav mis tau ua tiav thaum lub Cuaj Hlis 2014.