Vitamin E-TPGS (Tocofersolan) CAS 9002-96-4 D-α-Tocopherol ≥25.0%
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom ntawm Vitamin E-TPGS (Tocofersolan) (CAS: 9002-96-4) nrog cov khoom zoo.Ruifu Chemical tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, kev pabcuam zoo heev, me me thiab ntau ntau muaj.Yuav Vitamin E-TPGS,Please contact: alvin@ruifuchem.com
| Tshuaj npe | Vitamin E Polyethylene Glycol Succinate |
| Synonyms | Vitamin E-TPGS;TPGS;Tocofersolan;α-Tocopherol Polyethylene Glycol Succinate;D-α-Tocopherol Polyethylene Glycol 1000 Succinate;alpha-Tocopherol Polyethylene Glycol Succinate |
| Tshuag xwm txheej | Hauv Tshuag, Kev Lag Luam Loj |
| CAS Nr | 9002-96-4 |
| Molecular Formula | C33H54O5.(C2H4O)n |
| Melting Point | 34.0 ~ 38.0 ℃ |
| Qhov ntom | 1.01g / cm3 |
| rhiab heev | Huab cua Sensitive, Lub teeb rhiab heev, Moisture Sensitive |
| WGK Germany | 2 |
| Cia Temp. | Qhov chaw txias & qhuav (2 ~ 8 ℃) |
| COA & MSDS | Muaj |
| Qauv | Muaj |
| Tsev Neeg Tshuaj | Vitamin E Derivative |
| Hom | Ruifu Tshuaj |
| Cov khoom | Kev soj ntsuam Standards | Cov txiaj ntsig |
| Qhov tshwm sim | Tawm-dawb mus rau daj ntseg daj Waxy khoom | Ua raws |
| Kev txheeb xyuas (GC) | Lub sijhawm khaws cia ntawm lub ncov loj ntawm cov qauv kev daws teeb meem sib raug rau qhov kev daws teeb meem Standard | Ua raws |
| Melting Point | 34.0 ~ 38.0 ℃ | 36.0 ~ 36.6 ℃ |
| Assay D-alpha Tocopherol | ≥25.0% (C29H50O2) | 26.4% |
| Dawb Tocopherol | ≤ 1.5% | Ua raws |
| Kev sib hloov tshwj xeeb | ≥ + 24.0° | + 24.5 ° C |
| Solubility hauv dej | 20g Sample tuaj yeem yaj hauv 80ml Boiling Dej | Clear hauv 3 h |
| Acid nqi | ≤0.27ml (0.10 N Sodium Hydroxide) | 0,22ml ib |
| Heavy Metals (Pb) | ≤10ppm | <10ppm |
| Arsenic (As) | ≤1ppm | <1 ppm |
| Coj | ≤ 3ppm | <3 ppm |
| Mercury (Hg) | ≤ 0.1ppm | <0.010ppm |
| Residual Solvents | ||
| Ethyl Acetate | ≤ 50ppm | Tsis Pom |
| Ethanol | ≤ 50ppm | 23 ppm |
| Tag Nrho Phaj suav | ≤1000CFU / g | <10CFU/g |
| Yeasts thiab Pwm | ≤100CFU / g | <10CFU/g |
| Salmonella | Tsis zoo | Tsis zoo |
| Escherichia Coli | Tsis zoo | Tsis zoo |
| Psendomonas Aeruginosa | Tsis zoo | Tsis zoo |
| Staphylococcus Aureus | Tsis zoo | Tsis zoo |
| Infrared Spectrum | Raws li tus qauv | Ua raws |
| Xaus | Cov khoom tau raug kuaj & ua raws li cov lus qhia tshwj xeeb | |
Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv lub thawv kaw nruj nreem.Khaws rau hauv qhov chaw txias, qhuav (2 ~ 8 ℃) thiab lub tsev tso cua txias kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.
DEFINITION
Vitamin E Polyethylene Glycol Succinate yog ib qho kev sib tov tsim los ntawm esterification ntawm d-alpha tocopheryl acid succinate thiab polyethylene glycol.Cov ester sib tov muaj feem ntau ntawm mono-esterified polyethylene glycol thiab ib qho me me ntawm di-esterified polyethylene glycol.Nws muaj NLT 25.0% ntawm d-alpha tocopherol (C29H50O2).
IDENTIFICATION
• A. Gas Chromatographic Identification Test
Kev Ntsuam Xyuas: Ua raws li qhia hauv qhov kev xeem rau Cov Ntsiab Lus ntawm Alpha Tocopherol.
Kev lees txais cov txheej txheem: Lub sijhawm khaws cia ntawm lub ncov loj ntawm cov qauv kev daws teeb meem sib raug rau qhov kev daws teeb meem.
TXOJ CAI
• Cov ntsiab lus ntawm Alpha Tocopherol
Cov kuab tshuaj: 0.25 mL ntawm phenolphthalein TS hauv 1 L ntawm cawv
Cov txheej txheem sab hauv: 12 mg / mL ntawm ethyl arachidate hauv isooctane
Cov txheej txheem daws teeb meem: Hloov 32.5 mg ntawm USP Alpha Tocopherol RS mus rau cov tshuaj tiv thaiv tsim nyog.Ntxiv 2 mL ntawm pyridine thiab 0.5 mL ntawm N, O-bis (trimethylsilyl) trifluoroacetamide nrog 1% trimethylchlorosilane, thiab kub lub hwj ntawm 100 rau 10 min.Txias lub hwj, ntxiv 5.0 mL ntawm Internal standard tov tom qab 20 mL ntawm isooctane, thiab co.
Cov qauv kev daws teeb meem: Hloov kom muaj nuj nqis sib npaug rau 0.100-0.160 g ntawm Vitamin E Polyethylene Glycol Succinate molten ntawm 60 mus rau kab lis kev cai raj (txog 20 cm ntev thiab 2.5 cm inch) nruab nrog lub hau ntswj.Ntxiv 40-50 mg ntawm ascorbic acid thiab ob peb boiling chips, ua raws li 20 mL ntawm Solvent.[Ceeb Toom—Reflux cov tshuaj maj mam tsis muaj emission ntawm cov ntsiab lus.] Muab lub raj tso rau hauv ib lub qhov cub cua sov ntawm 100–150.Thaum cov qauv yog tag nrho yaj, ntxiv 0.25 g ntawm poov tshuaj hydroxide, thiab txuas ntxiv reflux rau 30 min.Tshem lub raj los ntawm tshav kub, thiab thaum cov ntsiab lus tseem kub, ntxiv 1-2 mL ntawm hydrochloric acid dropwise kom txog thaum cov xim liab ploj.[Ceev faj—Exothermic reaction.Cia cov kua qaub rau hauv qab ntawm lub raj kom tsis txhob txaws.] Txias lub raj, ces ntxuav ob sab ntawm lub raj nrog 20 mL dej.Ntxiv 5.0 mL ntawm Internal standard tov, hau, thiab co kom huv si sib tov.Cia lub raj kom sawv ntsug kom txog thaum ob txheej txheej sib txawv.Hloov 2.5-3.5 mL ntawm txheej sab sauv rau hauv cov tshuaj tiv thaiv tsim nyog, thiab ntxiv 2.0 mL ntawm pyridine tom qab 2.5 mL ntawm N, O-bis (trimethylsilyl) trifluoroacetamide nrog 1% trimethylchlorosilane.Kub lub hwj ntawm 100 rau 10 feeb.Txias, thiab tom qab ntawd ntxiv 12 mL ntawm isooctane.
Chromatographic system
(Saib Chromatography 621, System Suitability.)
Qauv: GC
Detector: Nplaim ionization
Kem: 0.25-mm × 15-m fused-silica capillary;coated nrog 0.25-µm zaj duab xis ntawm theem G27
Kub
Lub cev muaj zog: 280
NPE: 345
Kem: Saib Table 1.
Table 1
Qhov kub thiab txias (°) Qhov kub thiab txias (° / min) Qhov ntsuas kub kawg (°) Tuav lub sij hawm ntawm qhov ntsuas kub kawg (min)
260 20 340 1 ib
Carrier gas: Helium
Tus nqi ntws: 1.5 mL / min
Kev txhaj tshuaj loj: 1 µL
Kev txhaj tshuaj: Split ratio, 200: 1
Qhov system haum
Qauv: Standard tov
Suitability xav tau
Tailing yam: NMT 2.0 rau lub ncov alpha tocopherol
Tus txheeb ze tus qauv sib txawv: NMT 2.0% rau qhov piv ntawm alpha tocopherol ncov cheeb tsam mus rau sab hauv tus qauv ncov cheeb tsam
Kev tsom xam
Cov Qauv: Cov qauv kev daws teeb meem thiab cov qauv daws teeb meem
Xam cov feem pua ntawm d-alpha tocopherol (C29H50O2) hauv feem ntawm Vitamin E Polyethylene Glycol Succinate noj:
Result = (RU/RS) × (WS/WU) × 100
RU = Internal standard ratio (nruab thaj tsam ntawm alpha tocopherol / ncov cheeb tsam ntawm tus qauv sab hauv) los ntawm cov qauv tov
RS = Internal standard ratio (nruab thaj tsam ntawm alpha tocopherol / ncov cheeb tsam ntawm tus qauv sab hauv) los ntawm Standard tov
WS = qhov hnyav ntawm USP Alpha Tocopherol RS siv los npaj cov txheej txheem tshuaj (mg)
WU = qhov hnyav ntawm Vitamin E Polyethylene Glycol Succinate coj los npaj cov tshuaj (mg)
Kev lees txais: NLT 25.0%
TSEEM CEEB
• Optical Rotation, Specification Rotation 781S
[Ceeb toom-Qhov kev sim no txheeb xyuas d-alpha tocopherol tom qab saponification.]
Cov qauv kev daws teeb meem: Hloov 0.9 g ntawm Vitamin E Polyethylene Glycol Succinate, molten ntawm 60, mus rau ib lub raj uas haum nrog lub hau, thiab yaj hauv 10.0 mL cawv.Muab lub raj tso rau hauv ib qho thaiv cua sov ntawm 100-105.[Ceeb toom-Reflux cov tshuaj maj mam tsis muaj emission ntawm cov ntsiab lus.] Thaum tus qauv yog tag nrho yaj, ntxiv 2-3 pellets ntawm sodium hydroxide, thiab txuas ntxiv reflux rau 30 feeb ntxiv.Tshem lub raj los ntawm lub tshav kub, thiab thaum cov ntsiab lus tseem kub, neutralize siv phenolphthalein raws li qhov taw qhia los ntawm maj mam ntxiv 10 mL ntawm ib tug sib tov ntawm dej thiab hydrochloric acid (1: 1) kom txog thaum cov xim liab ploj.[Ceev faj-Exothermic tshuaj tiv thaiv.Cia cov kua qaub rau hauv lub raj sab hauv kom tsis txhob txaws.] Txias lub raj, hau, thiab co kom txog thaum cov khoom sib tov zoo.Ntxiv 25.0 mL ntawm heptane, hau, thiab co rau 1 min kom paub meej sib tov.Cia lub raj kom sawv ntsug kom txog thaum ob txheej txheej sib txawv.Hloov cov txheej saum toj kawg nkaus mus rau qhov huv huv, qhuav kab lis kev cai raj, tom qab ntawd ntxiv 10.0 mL dej rau cov tshuaj zoo.Cap, co, thiab cia cov khaubncaws sab nraud povtseg cais.Hloov cov txheej sab saud mus rau ib lub raj huv, qhuav.Ntxiv 10.0 mL ntawm poov tshuaj ferricyanide tov, npaj los ntawm dissolving 2 g ntawm poov tshuaj ferricyanide nyob rau hauv 10.0 mL ntawm 0.2 M sodium hydroxide, thiab hloov lub hau.Co lub zog rau 45 s, thiab cia cov khaubncaws sab nraud povtseg rau 30 feeb.Yog hais tias lub sab saum toj heptane txheej yog qhov tseeb, mus rau qhov ntsuas rau kev sib hloov tshwj xeeb;yog tias tsis meej, qhuav dhau anhydrous sodium sulfate ua ntej pib qhov kev xeem.[Ceeb toom-Siv cov txiaj ntsig ntawm qhov kev xeem rau Cov Ntsiab Lus ntawm Alpha Tocopherol los xam cov kev sib hloov tshwj xeeb.]
Kev lees txais: NLT + 24.0
• Solubility hauv dej
Qauv: 20 g ntawm melted Vitamin E Polyethylene Glycol Succinate
Kev tsom xam: Muab cov qauv tso rau hauv lub khob ntim rau ntawm lub tshuab nqus hlau nplaum.Tam sim ntawd ntxiv 80 mL ntawm boiling dej thaum stirring.Cia kom txias rau chav tsev kub nrog tas li stirring.
Kev lees txais cov qauv: Cov kev daws teeb meem yuav pom tseeb hauv 3 teev.
• Tus nqi Acid
Qauv: 1 g ntawm Vitamin E Polyethylene Glycol Succinate
Kev Ntsuam Xyuas: Dissolve tus qauv hauv 25 mL ntawm kev sib xyaw ntawm cawv thiab ether (1: 1) uas tau raug neutralized rau phenolphthalein nrog 0.1 N sodium hydroxide.Ntxiv 0.5 mL ntawm phenolphthalein TS, thiab titrate nrog 0.10 N sodium hydroxide kom txog thaum cov tshuaj tseem tshuav faintly liab tom qab co rau 30 s.
Kev lees paub: NMT 0.027 mEq / g, sib npaug rau NMT 0.27 mL ntawm 0.10 N sodium hydroxide
TSEEM CEEB
• Ntim thiab Cia: Khaws rau hauv cov thawv ntim nruj, thiab khaws cia tiv thaiv lub teeb.
• Labeling: Daim ntawv lo qhia txog cov ntsiab lus d-alpha tocopherol, qhia hauv mg/g.
• USP Reference Standards 11
USP Alpha Tocopherol RS
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
Vitamin E Polyethylene Glycol Succinate (Vitamin E-TPGS; TPGS; Tocofersolan) (CAS: 9002-96-4) yog cov khoom siv hluavtaws.Nws yog muaj raws li ib tug off-dawb mus rau daj ntseg daj waxy Khoom thiab yog xyaum tasteless.Chemically, nws yog ib qho kev sib xyaw uas muaj feem ntau ntawm monoesterified polyethylene glycol 1000, diesterified polyethylene glycol 1000, dawb polyethylene glycol 1000, thiab dawb tocopherol.
Vitamin E Polyethylene Glycol Succinate tau dav siv nyob rau hauv kev tshawb fawb tshuaj, raws li ib tug solubilizer, absorption txhawb, emulsifier, plasticizer thiab cab kuj ntawm dej-insoluble los yog rog soluble tshuaj xa system, xws li khoom dispersion, nqa mus rau lub ocular tshuaj xa, nqa mus rau intranasal. xa tshuaj, thiab lwm yam. Ua zaub mov additives.
Vitamin E Polyethylene Glycol Succinate yog dej-soluble derivative ntawm vitamin E, nws yog tsim los ntawm reacting pawg carboxyl ntawm vitamin E succinate nrog hydroxyl pawg ntawm polyethylene glycol.Vim tias nws muaj ob pawg vitamin E lipophilic thiab polyethylene glycol hydrophilic ntev saw, nws muaj cov khoom zoo surfactant thiab dej solubility, uas tuaj yeem ua rau kom nqus tau cov tshuaj insoluble hauv plab hnyuv, nce bioavailability.
Nyob rau hauv xyoo tas los no, ntau cov kev tshawb fawb tau pom tias TPGS tsis tsuas yog siv tau los ua cov tshuaj excipients, tab sis kuj muaj ntau yam ntxwv tshwj xeeb, raws li kev nqus tau zoo thiab cov tshuaj tiv thaiv ntau yam, TPGS tuaj yeem siv rau cov tshuaj, micelles, liposomes, TPGS-copolymer. cov neeg nqa khoom los txhim kho cov solubility, permeability thiab stability ntawm kev npaj, thiaj li mus cuag qeeb, tswj kev tso tawm thiab lub hom phiaj nyhuv, txhawb kev nqus ntawm cov tshuaj.
1. Pharmaceutical - Vitamin E-TPGS zoo heev rau kev nqus, bioavailability thiab kev ua tau zoo ntawm cov khoom xyaw tshuaj (APIs)
2. Khoom noj khoom haus - Vitamin E-TPGS yog siv los tsim cov tshuaj, tshwj xeeb tshaj yog cov tsim los txhim kho labsorption ntawm vitamin E thiab lwm yam lipophilic as-ham thiab nutraceuticals.
3. Khoom noj khoom haus thiab dej haus - Vitamin E-TPGS tuaj yeem ua haujlwm los txhawb cov khoom noj thiab dej haus, dej haus, dej thiab kua txiv hmab txiv ntoo.
4. Kev Kho Tus Kheej - Vitamin E-TPGS ua hauj lwm raws li ethanol dawb, hypoallergenic, tsis ua rau khaus emulsifier / excipient hauv kev saib xyuas tus kheej thiab daim ntawv thov kom zoo nkauj
5. Tsiaj Khoom Noj Khoom Haus - Vitamin E-TPGS muab cov vitamin E absorbable heev thiab bioavailable rau cov tsiaj uas tsis zoo nqus cov tshuaj vitamin E.
Vitamin E polyethylene glycol succinate yog ib qho esterified vitamin E (tocopherol) derivative feem ntau siv los ua solubilizer lossis emulsifying tus neeg saib xyuas vim nws cov khoom surfactant.Structurely, nws yog amphipathic thiab hydrophilic, tsis zoo li cov tocopherols, thiab yog li ntawd nws yog ib tug dej-soluble derivative uas yuav siv tau nyob rau hauv cov tshuaj formulations xws li tshuaj ntsiav, ntsiav tshuaj, kub-melt extrusion, microemulsions, tshuaj pleev ib ce, thiab parenterals.Ib qho ntawm cov ntawv thov tseem ceeb tshaj plaws yog nws siv los ua lub tsheb rau cov tshuaj lipid-based formulations.Nws kuj tseem siv tau los ua ib qhov chaw ntawm cov vitamin E. Vitamin E polyethylene glycol succinate tau ua tus cwj pwm ntawm kev hwm rau nws cov txheej txheem ntawm kev ua thiab kawm raws li Pglycoprotein inhibitor.
Vitamin E polyethylene glycol succinate yog incompatible nrog muaj zog acids thiab muaj zog alkalis.
GRAS teev.Muaj nyob rau hauv FDA Inactive Ingredients Database (ophthalmic solution or drops; oral capsules, solution, tablets; topical solution or drops).Muaj nyob rau hauv Canadian daim ntawv teev cov khoom uas tsis yog tshuaj.
