Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2 API Zoo
Muab Vonoprasan Fumarate thiab Lwm Yam Nruab Nrab
5-(2-Fluorophenyl)pyrrole-3-Carboxaldehyde CAS 881674-56-2
Pyridine-3-Sulfonyl Chloride CAS 16133-25-8
Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2
| Tshuaj npe | Vonoprasan Fumarate |
| Synonyms | TSI-438 |
| CAS Nr | 1260141-27-2;881681-01-2 |
| CAT Number | RF-API 99 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale nce mus txog pua pua ntawm Kilograms |
| Molecular Formula | C21H20FN3O6S |
| Molecular Luj | 461.463 ib |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Dawb los yog Yuav luag Dawb Crystalline Hmoov |
| ID 1 H-NMR | Raws li tus qauv |
| Identification IR | IR Absorption spectrum ntawm tus qauv concordant nrog cov qauv siv |
| Kev txheeb xyuas HPLC | Lub sijhawm khaws cia ntawm tus qauv ua raws li tus qauv siv |
| Cov ntsiab lus dej | ≤0.50% |
| Residue ntawm Ignition | ≤ 0.20% |
| Heavy Metals (raws li Pb) | ≤ 20ppm |
| Yam khoom muaj feem | |
| impurity A | ≤ 0.20% |
| Impurity B | ≤ 0.15% |
| Cov impurity C | ≤ 0.15% |
| Lwm yam impurity | ≤0.10% |
| Tag nrho cov impurities | ≤ 1.0% |
| Residual Solvents | |
| Methanol | ≤ 0.30% |
| Ethanol | ≤0.50% |
| Ethyl Acetate | ≤0.50% |
| Assay / Analysis Method | 98.0% ~ 102.0% (los ntawm HPLC) |
| Test Standard | Enterprise Standard |
| Kev siv | API |
Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo.
Vonoprazan Fumurate (TAK-438) (CAS: 1260141-27-2; 881681-01-2), proton twj tso kua mis inhibitor (PPI), yog ib tug muaj zog thiab hais lus active poov tshuaj sib tw acid blocker (P-CAB), nrog antisecretory kev ua si.Vonoprazan Fumarate inhibits H +, K + -ATPase kev ua haujlwm hauv porcine gastric microsomes nrog IC50 ntawm 19 nM ntawm pH 6.5.Vonoprazan Fumarate (Takecab), nrhiav tau thiab tsim los ntawm Takeda thiab Otsuka, tau pom zoo los ntawm PMDA ntawm Nyiv thaum lub Kaum Ob Hlis 2014. Vonoprazan Fumarate feem ntau yog siv los kho tus kab mob helicobacter pylori, gastroesophageal reflux, peptic ulcer, duodenal ulcer, esophagitis, ulcer thiab lwm yam kab mob gastric acid.Cov khoom muaj zog, ntev inhibition ntawm gastric acid secretion.Ntawm cov tshuaj kho mob, Vonoprasan Fumarate muaj kev cuam tshuam me ntsis ntawm lwm cov enzymes thiab me ntsis cuam tshuam rau kev ua haujlwm ntawm lub cev ntawm lub cev.Nws muaj kev nyab xeeb thiab zam tau ntau dua.
