Zoledronic Acid CAS 118072-93-8 Purity ≥99.7% API Hoobkas Zoo
Muab khoom nrog High Purity thiab ruaj khov zoo
Lub npe tshuaj: Zoledronic Acid
CAS: 118072-93-8 Nr
Muaj zog Farnesyl Diphosphate (FPP) Synthase Inhibitor
API High Quality, Commercial Production
| Tshuaj npe | Zoledronic Acid |
| Synonyms | ZOL 446, ZA, Zoledronate, CGP-4244, GP42446A, Zometa, Zomera;[1-Hydroxy-2-(1H-imidazol-1-yl)-ethylidene] bisphosphonic acid |
| CAS Nr | 118072-93-8 |
| CAT Number | RF-API 90 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale nce mus txog pua pua ntawm Kilograms |
| Molecular Formula | C5H10N2O7P2 |
| Molecular Luj | 272.09 Nws |
| Melting Point | 193.0 ~ 204.0 ℃ |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Dawb rau Off-White Crystalline Hmoov |
| Kev txheeb xyuas | IR Spectrum ntawm tus qauv sib raug raws li tus qauv siv |
| pH | 2.0 ~ 4.0 |
| Solubility | Sparingly Soluble nyob rau hauv 0.1N Sodium Hydroxide tov, me ntsis soluble nyob rau hauv dej thiab 0.1N Hydrochloric Acid, xyaum insoluble nyob rau hauv Ethanol |
| Yam khoom muaj feem | |
| Txhua tus neeg impurity | ≤0.10% |
| Tag nrho cov impurities | ≤ 0.30% |
| Poob rau ziab | 5.0% ~ 7.0%. |
| Chloride | ≤ 0.02% |
| Phosphite | ≤0.50% |
| Phosphate | ≤0.50% |
| Hnyav Hlau | ≤10ppm |
| Purity | ≥99.7% |
| Test Standard | Enterprise Standard |
| Kev siv | API, FPP Synthase Inhibitor, Hypercalcemia ntawm Malignancy (HCM) |
Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.
Zoledronic Acid (CAS 118072-93-8) yog ib qho muaj zog bisphophonate farnesyl diphosphate (FPP) synthase inhibitor (IC50 = 20 nM).Inhibits osteoclast-mediated pob txha resorption.Kuj inhibits Ras signaling thiab qog loj hlob, thiab induces apoptosis hauv pancreatic cancer hlwb.Reverses epithelial-mesenchymal kev hloov pauv thiab inhibits qog nqaij hlav qog noj ntshav ntawm lub mis ntawm kev ua haujlwm ntawm NF-κB.Zoledronic acid tau pom zoo los ntawm US FDA xyoo 2001 rau kev kho mob hypercalcemia ntawm malignancy, ib qho teeb meem metabolic uas tuaj yeem ua rau muaj kev phom sij rau lub neej.Hypercalcemia ntawm malignancy tuaj yeem tshwm sim txog li 50% ntawm cov neeg mob uas tau kuaj pom tias muaj mob qog noj ntshav siab, ntau yam myeloma, thiab mob qog noj ntshav tsis zoo.Qhov mob no tshwm sim thaum cov tshuaj moieties tsim los ntawm cov qog ua rau overstimulation ntawm osteoclasts.Thaum muaj kev nce hauv pob txha degradation, muaj kev tso tawm ntawm calcium rau hauv cov ntshav.Thaum cov piam thaj ntau ntawm calcium nce siab sai, lub raum tsis tuaj yeem tswj hwm qhov hnyav, thiab qhov tshwm sim hypercalcemia.Zoledronic acid zoo txo cov ntshav calcium ntau los ntawm inhibition ntawm pob txha resorption (inhibition ntawm osteoclastic kev ua si thiab induction ntawm osteoclast apoptosis).Tsis tas li ntawd, zoledronic acid tau pom zoo los ntawm US FDA rau kev kho mob ntawm ntau yam myeloma thiab pob txha metastases txuam nrog cov qog nqaij hlav qog nqaij hlav (xws li, prostrate thiab ntsws).
