7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2 Pite > 99.0% (HPLC) Afatinib Dimaleate Faktori Entèmedyè
Ruifu Chimik Pwovizyon pou Entèmedyè nan Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino) acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Asid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Asid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-yon sèl CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5
Non Chimik | 7-Chloro-6-Nitro-4-Hydroxyquinazoline |
Sinonim | 7-Chloro-4-Idroksi-6-Nitroquinazoline;7-Kloro-6-Nitro-4-Quinazolinol;7-Kloro-6-Nitro-4-Quinazolinone;7-Kloro-6-Nitro-4 (3H)-Quinazolinone;7-Chloro-6-Nitro-3,4-Dihydroquinazolin-4-yon sèl;7-Chloro-6-Nitroquinazolin-4(3H)-yon sèl |
Nimewo CAS | 53449-14-2 |
Nimewo CAT | RF-PI2030 |
Estati Stock | Nan Stock, Pwodiksyon Echèl Jiska Tòn |
Fòmil molekilè | C8H4ClN3O3 |
Pwa molekilè | 225.59 |
Sansiblite | Chalè sansib |
Solibilite | Yon ti kras soluble nan Dimethylformamide |
Mak | Ruifu Chimik |
Atik | Espesifikasyon |
Aparans | Limyè jòn poud limyè mawon |
Idantifikasyon (HPLC) | Tan retansyon echantiyon an ta dwe matche ak estanda |
Pite / Metòd analiz | >99.0% (HPLC) |
Pwen k ap fonn | 300.0 ~ 303.0 ℃ |
Kontni dlo (KF) | <0.50% |
Rezid sou ignisyon | <0.30% |
Enpurte 1 | <0.50% (7-Chloro-4-Hydroxyquinazoline CAS: 31374-18-2) |
Enpurte 2 | <0.50% (5,7-Dichloro-4[1H]quinazolinone) |
Enpurte 3 | <1.00% (7-Chloro-8-Nitro-4[1H]quinazolinone) |
Lòt moun ki pa marye enpurte | <0.20% |
Enpurte total | <1.00% |
Metal lou (tankou Pb) | <20ppm |
Enfrawouj Spectrum | Konfòm ak estrikti |
Spectre proton RMN | Spectre proton RMN |
Tès Creole | Enterprise Standard |
Itilizasyon | Entèmedyè nan Afatinib, Afatinib Dimaleate |
Pake: Boutèy, sak papye aliminyòm, 25kg / tanbou katon, oswa selon kondisyon kliyan an
Kondisyon Depo:Sere nan resipyan ki fèmen nan yon kote ki fre ak sèk;Pwoteje kont limyè ak imidite
7-Chloro-6-Nitro-4-Hydroxyquinazoline (CAS: 53449-14-2) se yon entèmedyè nan Afatinib Dimaleate (CAS: 850140-73-7).Afatinib se yon fanmi irevokabl ErbB nan blockers ki siprime transmisyon enfòmasyon ak bloke gwo chemen ki enplike nan kwasans selil kansè ak divizyon.Paske mekanis transdiksyon enfòmasyon fanmi ErbB ka deklanche pa plizyè homodimer ak heterodimers, anpèchman similtane nan plizyè manm fanmi ErbB (tankou EGFR, HER2, ErbB3 ak ErbB4) ka efektivman entèwonp transdiksyon enfòmasyon en.Yo itilize afatinib pou trete yon sèten kalite kansè nan poumon (kansè nan poumon ki pa ti selil) ki gaye nan lòt pati nan kò a.Li fè pati yon klas nan dwòg ke yo rekonèt kòm inibitè kinaz.Li travay pa ralanti oswa sispann kwasans selil kansè yo.Li mare nan yon sèten pwoteyin (reseptè epidèm-EGFR) nan kèk timè.