Afatinib Dimaleate Entèmedyè CAS 314771-76-1 Pite> 99.0% (HPLC) Faktori

Deskripsyon kout:

Non chimik: (S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine

CAS: 314771-76-1

Pite:> 99.0% (HPLC)

Aparans: Limyè jòn poud jòn

Entèmedyè nan Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

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Deskripsyon:

Ruifu Chimik Pwovizyon pou Entèmedyè nan Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino) acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Asid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Asid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-yon sèl CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Pwopriyete chimik:

Non Chimik	(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine
Sinonim	N4-(3-Chloro-4-Fluorophenyl)-7-[[(3S)-Tetrahydro-3-Furanyl]oxy] -4,6-Quinazolinediamine;Afatinib enpurte B;Afatinib-des (4-Dimethylamino-2-en-1-oxo)butil;Des(4-Dimethylamino-2-en-1-oxo)butil Afatinib
Nimewo CAS	314771-76-1
Nimewo CAT	RF-PI2028
Estati Stock	Nan stock, pwodiksyon kapasite 100MT/ane
Fòmil molekilè	C18H16ClFN4O2
Pwa molekilè	374.8
Pwen bouyi	559.0±50.0℃
Dansite	1.473±0.060 g/cm3
Mak	Ruifu Chimik

Espesifikasyon:

Atik	Espesifikasyon
Aparans	Limyè jòn poud jòn
Idantifikasyon	Tan Retansyon Prensipal Pik nan HPLC ta dwe koresponn ak estanda a
Pite / Metòd analiz	>99.0% (HPLC)
Pèt sou siye	<0.50%
Rezid sou ignisyon	<0.20%
Single enpurte	<0.50%
Enpurte total	<1.00%
Metal lou (tankou Pb)	≤20ppm
Tès Creole	Enterprise Standard
Itilizasyon	Entèmedyè nan Afatinib Dimaleate (CAS: 850140-73-7)

Pake & Depo:

Pake: Boutèy, sak papye aliminyòm, 25kg / tanbou katon, oswa selon kondisyon kliyan an

Kondisyon Depo:Sere nan resipyan ki fèmen nan yon kote ki fre ak sèk;Pwoteje kont limyè ak imidite

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Aplikasyon:

(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine (CAS: 314771-76-1) se yon entèmedyè nan Afatinib Dimaleate. (CAS: 850140-73-7).Afatinib se dezyèm jenerasyon ki pisan ak irevokabl doub inibitè nan reseptè faktè kwasans epidèm (EGFR) ak reseptè faktè kwasans epidèm imen 2 (HER2) tirozin kinaz, devlope pa Boehringer Ingelheim, Almay.Li kapab irevokabl anpeche aktivite tirozin kinaz la lè li sibi reyaksyon Michael ak gwoup thiol cysteine nan pozisyon 797 EGFR la.Fonksyon: 1. Tankou Lapatinib ak Neratinib, Afatinib se yon inhibitor pwoteyin kinaz ki tou irevokabl inibit reseptè faktè kwasans epidèm imen 2 (Her2) ak reseptè faktè kwasans epidèm (EGFR) kinaz.2. Afatinib pa sèlman aktif kont mitasyon EGFR ki vize pa TKI premye jenerasyon tankou erlotinib oswa gefitinib, men tou kont mitasyon tankou T790M ki pa sansib a terapi estanda sa yo.Akòz aktivite adisyonèl li kont Her2, yo ap envestige l pou kansè nan tete ak lòt kansè ki lakòz EGFR ak Her2.3. Afatinib se yon dwòg pou tretman premye liy pasyan ki gen diferan kalite metastatik (EGFR mitasyon pozitif) ki pa ti selil kansè nan poumon (NSCLC).Li aji kòm yon inibitè kovalan irevokabl nan reseptè tirozin kinas reseptè faktè kwasans epidèm (EGFR) ak erbB-2 (HER2).