Diethylphosphonoacetic Asid CAS 3095-95-2 Pite > 99.5% (HPLC) Afatinib Dimaleate Faktori Entèmedyè
Ruifu Chimik Pwovizyon pou Entèmedyè nan Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino) acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Asid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Asid CAS 3095-95-2
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7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
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Non Chimik | Asid diethylphosphonoacetic |
Sinonim | 2-(Diethoxyphosphoryl) asid acetic;(Diethoxyphosphinyl) asid acetic;Diethyl Carboxymethylphosphonate;NSC 272281 |
Nimewo CAS | 3095-95-2 |
Nimewo CAT | RF-PI2024 |
Estati Stock | Nan Stock, Kapasite Pwodiksyon 30MT / Mwa |
Fòmil molekilè | (C2H5O)2P(O)CH2CO2H |
Pwa molekilè | 196.14 |
Pwen bouyi | 150℃/0.05 mmHg (limen) |
Dansite | 1.220 g/mL nan 25℃ (lit.) |
Endèks refraktif | n20/D 1.445 (lit.) |
Mak | Ruifu Chimik |
Atik | Espesifikasyon |
Aparans | Likid san koulè |
Idantifikasyon (HPLC) | Tan an retansyon nan pik prensipal la jwenn nan echantiyon an se nan 5% nan echantiyon referans la. |
Pite / Metòd analiz | >99.5% (HPLC) |
Enfrawouj Spectrum | Konfòm ak estrikti |
Spectre proton RMN | Konfòm ak estrikti |
Imidite (KF) | <0.50% |
Enpurte total | <0.50% |
Tès Creole | Enterprise Standard |
Itilizasyon | Entèmedyè nan Afatinib Dimaleate (CAS: 850140-73-7) |
Pake: Fliyò boutèy, 25kg / tanbou, oswa selon kondisyon kliyan an
Kondisyon Depo:Sere nan resipyan ki fèmen nan yon kote ki fre ak sèk;Pwoteje kont limyè ak imidite
Asid Diethylphosphonoacetic (CAS: 3095-95-2), Aji kòm yon nukleofil pou reyaksyon adisyon nukleofil pou sentèz epoksid alèn Reyaktif pou: syans estereoselectivite reyaksyon Staudinger;Fòmasyon enantioselectif nan dyol atravè epoksidasyon ak reyaksyon idratasyon;Reyaksyon Horner-Wadsworth-Emmons;Remote chelation kontwole Iland-Claisen reyajman;Reyaksyon Ugi-Dieckmann pou sentèz dérivés asid tetramik;Yo itilize pou fè entèmedyè fosfonoester pou reyaksyon HEW intramolekilè.Asid Diethylphosphonoacetic se yon entèmedyè nan Afatinib Dimaleate (CAS: 850140-73-7).Afatinib Dimaleate te apwouve pa US Food and Drug Administration (FDA) an 2013 pou tretman kansè nan poumon ki pa ti selil (NSCLC).Espesyalman, li te apwouve pou pasyan ki prezante timè NSCLC metastatik ki gen delesyon ekson reseptè faktè kwasans epidèm (EGFR) oswa mitasyon ekson 21.Afatinib Dimaleate se yon inibitè kovalan nan ErbB tirozin kinaz (tyk), ki downregulate ErbB siyal pa obligatwa irevokabl nan sit obligatwa EGFR tyk.