Methyl 2-Oxoindoline-6-Carboxylate CAS 14192-26-8 Pite > 99.0% (HPLC) Nintedanib Esylate Faktori Entèmedyè
Shanghai Ruifu Chemical Co, Ltd se dirijan manifakti ak founisè Methyl 2-Oxoindoline-6-Carboxylate (CAS: 14192-26-8) ak bon jan kalite segondè, pwodiksyon komèsyal yo.
Non Chimik | Methyl 2-Oxoindoline-6-Carboxylate |
Sinonim | 2-Oxoindoline-6-Carboxylic Asid Methyl Ester;Methyl Oxindole-6-carboxylate |
Nimewo CAS | 14192-26-8 |
Nimewo CAT | RF-PI1524 |
Estati Stock | Nan Stock, Pwodiksyon Echèl Jiska Tòn |
Fòmil molekilè | C10H9NO3 |
Pwa molekilè | 191.19 |
Pwen k ap fonn | 184.0 ~ 190.0 ℃ |
Mak | Ruifu Chimik |
Atik | Espesifikasyon |
Aparans | Limyè jòn poud mawon |
Spectre 1H RMN | Ki konsistan avèk estrikti |
Pite / Metòd analiz | >99.0% (HPLC) |
Pèt sou siye | <1.00% |
Enpurte total | <1.00% |
Tès Creole | Enterprise Standard |
Itilizasyon | Entèmedyè nan Nintedanib Esylate (CAS: 656247-18-6) |
Methyl 2-Oxoindoline-6-Carboxylate (CAS: 14192-26-8) wout sentetik
Pake: Boutèy, sache papye aliminyòm, 25kg / tanbou katon, oswa selon kondisyon kliyan an.
Kondisyon Depo:Sere nan resipyan ki fèmen nan yon kote ki fre ak sèk;Pwoteje kont limyè ak imidite.
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Methyl 2-Oxoindoline-6-Carboxylate (CAS: 14192-26-8) se yon entèmedyè ki itilize pou prepare Nintedanib Esylate (CAS: 656247-18-6).Nintedanib Esylate se yon inibitè ki pisan, oral trip angiokinase devlope pa Boehringer Ingelheim ki vize chemen proangiogenic ak pro-fibrotic medyatè pa reseptè faktè kwasans endothelial vaskilè, reseptè faktè kwasans fibroblast ak fanmi reseptè faktè kwasans ki sòti nan plakèt, osi byen ke Src ak Flt-3. kinaz.Nintedanib Esylate te apwouve pou tretman fibwoz poumon idiopatik (IPF), yon kondisyon kote poumon yo vin piti piti sikatris sou tan, pa US FDA a nan mwa Oktòb 2014 ak pa EMA a nan Janvye 2015. FDA a akòde nintedanib esylate rapid-track. , revizyon priyorite, pwodwi òfelen, ak deziyasyon zouti.Li te apwouve tou pa EMA nan Novanm 2014 pou tretman kansè nan poumon ki pa ti selil an konbinezon ak docetaxel apre premye liy chimyoterapi.
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