Hydroxypropyl-β-Cyclodextrin CAS 128446-35-5 (HP-β-CD) Pharmaceutical Excipients

Short Description:

Chemical Name: Hydroxypropyl-β-Cyclodextrin

Synonyms: Cyclodextrin HPB; HPBCD; HP-β-CD

CAS: 128446-35-5

White or Almost White Amorphous or Crystalline Powder

Contact: Dr. Alvin Huang

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E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

Description:

Ruifu Chemical is the leading manufacturer of Hydroxypropyl-β-Cyclodextrin (HPBCD; HP-β-CD) (CAS: 128446-35-5) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Hydroxypropyl-β-Cyclodextrin, Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name	Hydroxypropyl-β-Cyclodextrin
Synonyms	Cyclodextrin HPB; Hydroxypropyl-Beta-Cyclodextrin; (2-Hydroxypropyl)-β-Cyclodextrin; (2-Hydroxypropyl)-beta-Cyclodextrin; beta-Hydroxypropylcyclodextrin; HBC; HPBCD; HP-β-CD
Stock Status	In Stock, Commercial Production
CAS Number	128446-35-5
Molecular Formula	C63H112O42
Molecular Weight	1541.54 g/mol
Melting Point	262.0~269.0℃
Density	1.05
Specific Rotation [a]20/D	+120° to +135° (C=1, H2O)
Water Solubility	Soluble in Water
COA & MSDS	Available
Free Sample	Available
Origin	Shanghai, China
Brand	Ruifu Chemical

Specifications:

Items	Specifications	Results
Appearance	White Powder, Insipid, Innocent	Conforms
IR Spectrum	Same Absorption Bands with USP Hydroxypropyl Betadex RS	Conforms
pH	5.0~7.5	6.57
Clarity of Solution	Clear and Colorless Solution	Conforms
Loss on Drying	≤10.0%	3.5%
Residue on Ignition	≤0.20%	0.09%
Heavy Metals	≤20ppm	<10ppm
Chloride	≤0.05%	<0.05%
Molar Substitution	0.4~1.5	0.63
Conductivity	10% (w/v) Water Solution ≤200μS/cm	154µS/cm
Degree of Substitution	2.8~10.5	5.3
Residue Betadex	≤1.50%	0.12%
Propylene Glycol	≤2.50%	0.29%
Propylene Oxide	≤1ppm	<1ppm
Any Other Single Impurity	≤0.25%	<0.25%
Sum of Other Impurities	≤1.00% (Excluding Betadex and Propylen Glycol)	0.51%
TAMC	≤1000cfu/g	30cfu/g
TYMC	≤100cfu/g	10cfu/g
Escherichia Coli	Not Detectable	Conforms
Salmonella	Absent	Absent
Bacterial Endotoxins	<10IU/g	<10IU/g
Conclusion	Tested and Complies with the Standard USP35

Package/Storage/Shipping:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Protect from light and moisture. Incompatible with strong oxidizing agents.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

128446-35-5 - Risk and Safety:

Safety Description	24/25 - Avoid contact with skin and eyes.
WGK Germany	3
RTECS	GU2293332
HS Code	3505100000

128446-35-5 - Uses:

Hydroxypropyl-β-Cyclodextrin (HPBCD; HP-β-CD) (CAS: 128446-35-5) is a widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with HP-β-CD. Enteric coating, sustained release formulations, buccal and transdermal drug delivery.
Hydroxypropyl-β-Cyclodextrin, a hydroxyalkyl derivative, finds application as a formulation vehicle that is used to enhance the solubility of the drugs in aqueous solutions for the successful delivery of medical agents to biological systems. It is generally employed as a substitute for α-, β- and γ-Cyclodextrins.

128446-35-5 - Pharmaceutical Applications:

Hydroxypropyl betadex has been widely investigated in pharmaceutics and has principally been used as a solubilizer for hydrophobic molecules in oral liquids,oral solids, parenterals, pressurized metered dose inhalers, dry powder inhalers, and topical formulations. It has also been shown to act as a stabilizer during processing and storage of formulations. Hydroxypropyl betadex inclusion complexes have been reported to show mechanical properties distinct from the pure materials. The reported advantage of hydroxypropyl betadex over unsubstituted b-cyclodextrin is its greater water solubility.

128446-35-5 - Function:

1. Solubilization and solubilization, make insoluble drugs dissolve, improve the solubility of active components of oily drugs, target drug delivery and protect the effectiveness of drug ingredients.
2. Improve the bioavailability of the drug, increase the curative effect of the drug or reduce the dosage.
3. Adjust or control the release rate of drugs to reduce the side effects.
4. Cover up the bad smell.

128446-35-5 - Application:

1) In pharmaceutical field,
1. Hydroxypropyl Beta Cyclodextrin can increase the solubility of the medicine and biological availability, also add up the good effect and decrease the dose.
2. HP-β-CD can control or adjust the reactive speed, lower the drug toxicity and enhance the stability of drugs.
3. An ideal injection solubilizer and drug excipients because of lower surface activity and hemolytic activity, no muscle irritation.
4. HP-β-CD is not only be used in oral drugs, injection, mucosal drug delivery system, transdermal drug delivery system, lipotropy targeting drug carrier, but also can be used as protein protective agent and stabilizer.
5. To improve organoleptic properties of bitter or unpleasant actives.
2) In food field,
1. HP-β-CD can prevent evaporation of volatile substances maintaining the stability of its nutrients, get rid of the terrible smell and can significantly enhance the effects of emulsification with the combined use of food emulsifiers.
2. HP-β-CD can also make preservative of food release slowly, raise the effect of anti-corrosion and extend the shelf life of food.
3) In Cosmetics Industry
1. In the cosmetics raw materials used as stabilizer, emulsifier, solubilizer etc.
2. HP-β-CD can reduce stimulation to skin, and enhance the stability of the effective components
3. HP-β-CD can reduce or mask bad odor of nutrition molecular.
4. Prevent nutrient composition of volatile, oxidation, increase the infusibility, essence, perfume water-soluble and Keep the fragrance slow release and lasting.