1-Methyl-3-Pyrrolidinol CAS 13220-33-2 Ịdị ọcha> 98.0% (GC)
Ruifu Chemical bụ onye na-emepụta 1-Methyl-3-Pyrrolidinol (3-Hydroxy-1-Methylpyrrolidine) (CAS: 13220-33-2) nwere oke mma.Ruifu Chemical nwere ike ịnye nnyefe zuru ụwa ọnụ, ọnụahịa asọmpi, ọrụ magburu onwe ya, obere na nnukwu ọnụọgụ dị.Ịzụta 1-Methyl-3-Pyrrolidinol,Please contact: alvin@ruifuchem.com
Aha Chemical | 1-Methyl-3-Pyrrolidinol |
Ụdị okwu | N-Methyl-3-Pyrrolidinol;3-Hydroxy-1-Methylpyrrolidine;N-Methyl-Pyrrolidin-3-ol;N-Methyl-Pyrrolidinyl mmanya;1-Methylpyrrolidin-3-ol |
Ọnọdụ Ahịa | Na ngwaahịa, Mmepụta Azụmahịa |
Nọmba CAS | 13220-33-2 |
Usoro ihe omimi | C5H11NO |
Ibu molekụla | 101.15 g / mol |
Ebe esi nri | 75 ℃/12 mmHg |
Ebe mgbari | 71 ℃ |
Njupụta | 0.921 g/ml na 25 ℃ (ọkụ) |
Ntụgharị ntụgharị n20/D | 1.464 (ọkụ) |
Mmetụta | Mmetụta ikuku, Hygroscopic |
Solubility | Soluble na Mmiri, Soluble na Mmanya, Ether na Benzene |
COA & MSDS | Dị |
Ihe atụ | Dị |
Mmalite | Shanghai, China |
Ụdị | Ruifu Chemical |
Ihe | Ụkpụrụ nyocha | Nsonaazụ |
Ọdịdị | Mmiri mmiri na-acha odo odo | Mmiri mmiri na-acha odo odo |
Mmiri nke Karl Fischer | <0.20% | 0.15% |
Ụzọ ịdị ọcha / nyocha | > 98.0% (GC) | 98.57% |
Njupụta (20 ℃) | 0.920-0.923 | Na-akwado |
Ntụgharị ntụgharị n20/D | 1.463-1.465 | Na-akwado |
Spectrum infrared | Nkwekọ na Structure | Na-akwado |
1H NMR Spectrum | Nkwekọ na Structure | Na-akwado |
Mmechi | A nwalela ngwaahịa a wee kwado nkọwa ndị enyere |
ngwugwu:Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Debe akpa ahụ nke ọma ma chekwaa n'ebe dị jụụ, kpọrọ nkụ (2 ~ 8 ℃) yana ụlọ nkwakọba ihe nke ọma na-esi na ihe ndị na-adabaghị adaba.Chebe site na ìhè na mmiri mmiri.
Mbupu:Jiri ikuku na-ebuga ụwa niile site na FedEx / DHL Express.Nye nnyefe ngwa ngwa na ntụkwasị obi.
Tinye 1,2,4-Butanetriol na glacial acetic acid na mmeghachi omume ite, kpalie na okpomọkụ ruo banyere 100 ℃, tinye akọrọ hydrogen chloride gas, na-emeghachi omume na 90 ~ 110 ℃ maka 30h, mgbe nnukwu ego nke hydrogen chloride malitere. na-apụta na gas ọdụ, a na-enyocha njedebe nke mmeghachi omume na hydrogen chloride kwụsịrị.Mgbe ọ dị jụụ, a na-ahapụ ihe ahụ, na-asa ya na ngwọta sodium carbonate zuru ezu, ma tinye ya n'okpuru nrụgide na-ebelata, na 120 ruo 135 ℃.(12.6 ruo 13. 3kPa) ntakiri, I .e., 1,4-Dichloro-2-Butanol mmanu mmanu, na-enye 50% ~ 60%.
Agbakwunyere cyclization ihe ngwọta mmiri nke 1,4-Dichloro-2-Butanol na Methylamine na ite cyclization, wee kpoo ọkụ ruo 120 ℃.N'okpuru kpo oku mechiri emechi, a na-akpalikwa mmeghachi omume maka 10h.Mgbe ọ dị jụụ, a gbakwụnye sodium hydroxide siri ike, ma kpochaa nnu inorganic nke nwere mmiri mmiri.The mmanụ oyi akwa e kewapụrụ na doro na agụụ distillation, na akụkụ nke 76-85 ℃.(2.1 kPa) anakọtara ka ọ bụrụ ngwaahịa emechara.Mwepụta nke akwa akwa mmiri na benzene na-ewepụtakwa akụkụ nke 1-Methyl-3-Pyrrolidinol.Mkpụrụ ahụ dị ihe dịka 60%.
3. Isi usoro:
3.1 Usoro mmeghachi omume dochie anya: jikwaa oge mmeghachi omume ma chọpụta njedebe mmeghachi omume
3.2 Vacuum distillation usoro nke 1,4-Dichloro-2-Butanol: akara agụụ ogo nke agụụ distillation na ntakiri okpomọkụ.
3.3 Usoro mmeghachi omume cyclization: njikwa mmeghachi omume okpomọkụ na oge
3.4 1-Methyl-3-Pyrrolidinol agụụ distillation usoro: akara agụụ ogo nke agụụ distillation na obere okpomọkụ okpomọkụ.
4. Isi njikwa mma:
Ogo akara akara 1: 1,2,4-Butanetriol raw material standard standard
Ebe njikwa mma 2: Ụkpụrụ njikwa njikwa etiti maka mmeghachi omume ịgba ígwè
Ebe njikwa mma 3: 1,4-Dichloro-2-Butanol ụkpụrụ dị n'etiti
Ebe njikwa mma 4: 1-Methyl-3-Pyrrolidinol gụchara ọkọlọtọ ngwaahịa ngwaahịa
Ọdịnaya Ọdịnaya: Were ngwaahịa a wee nwalee ya dịka usoro ikpebi mmiri siri dị (Usoro nke mbụ A nke mgbakwunye Ⅷ M, 2010 Edition of the People's Republic of China Pharmacopoeia).Ọdịnaya nke mmiri agaghị agafe 0.2%.
Njupụta nke ikwu: Njupụta nke ngwaahịa a (Ihe mgbakwunye VI A nke akụkụ II, mbipụta 2010) bụ 0.920 ~ 0.923
Ntụgharị ntugharị: Ndekọ ntugharị nke ngwaahịa a (Ihe mgbakwunye VI F nke akụkụ II nke mbipụta 2010) bụ 1.463 ~ 1.465
Mkpebi ọdịnaya: Ọdịnaya nke 1-Methyl-3-Pyrrolidinol ekwesịghị ịbụ ihe na-erughị 98.0% site na chromatography gas (Ihe mgbakwunye Ⅴ E, Nkebi II, mbipụta 2010).
Ogidi: Capillary na silica gbazere SPB-5, n'ime dayameta 0.32mm, ogologo 30m
T injector: 300 ℃
FID: 320 ℃
T kọlụm: 80 ℃ maka 5 nkeji, na 200 ℃ na 5 ℃ / min, mgbe ahụ na 200 ℃ maka 7 min.
Onye na-ebu: Helium na 1 ml / min
Oke nkewa: 100:1
Nri: 1 microliter
Ngwọta ule: igbari 200mg nke ihe nlele n'okpuru nyocha na 10ml nke methanol.Tinye 1 microliter.1μl gbabara n'ime chromatograph gas iji dekọọ chromatogram.A gbakọọ ọdịnaya nke 1-Methyl-3-Pyrrolidinol site na usoro nhazi oke mpaghara.
Kedu ka esi azụta?Biko kpọtụrụDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Synthesis omenala?Nwere ike ịnye ọrụ nhazi ahaziri iche ka ọ dabara mkpa nyocha gị nke ọma.
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A na-eji 1-Methyl-3-Pyrrolidinol (3-Hydroxy-1-Methylpyrrolidine) (CAS: 13220-33-2) mee ihe dị ka onye na-emepụta ihe na-emepụta ihe na-emepụta ihe na-emepụta ọgwụ na ụlọ ọrụ ọgwụ.
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