3-Methyl-6-Nitroindazole CAS 6494-19-5 Ịdị ọcha>98.0% (HPLC)
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Aha Chemical | 3-Methyl-6-Nitroindazole |
Ụdị okwu | 3-Methyl-6-Nitro-1H-Indozole;6-Nitro-3-Methylindazole |
Nọmba CAS | 6494-19-5 |
Nọmba CAT | RF2682 |
Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
Usoro ihe omimi | C8H7N3O2 |
Ibu molekụla | 177.16 |
Ebe Na-agbaze | 184.0 ruo 188.0 ℃ |
Ebe esi nri | 384.9 ± 22.0 ℃ |
Njupụta | 1,437 |
Solubility | Chloroform (obere), methanol (obere) |
Ụdị | Ruifu Chemical |
Ihe | Nkọwapụta |
Ọdịdị | Edo na-acha odo odo ruo ọchịchịrị gbara ọchịchịrị ruo ntụ ntụ ka kristal |
Ụzọ ịdị ọcha / nyocha | > 98.0% (HPLC) |
Ebe Na-agbaze | 184.0 ruo 188.0 ℃ |
Ọnwụ na ihicha | <1.00% |
Mgbakọta adịghị ọcha | <2.00% |
Spectrum infrared | Dabara na Ọdịdị |
Ọnụ ego nke Proton NMR Spectrum | Dabara na Ọdịdị |
Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
Ojiji | Ndị na-emepụta ọgwụ na etiti;Pazopanib Hydrochloride Intermediate |
ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri
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Uru?Ogo kachasị elu, ọnụ ahịa dị ọnụ ala, ọrụ ọkachamara na nkwado teknụzụ, nnyefe ngwa ngwa.
OgoNkwenye?Usoro njikwa mma siri ike.Ngwá ọrụ ọkachamara maka nyocha gụnyere NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, wdg.
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MOQ?Enweghị MOQ.A na-anabata obere usoro.
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Synthesis omenala?Nwere ike ịnye ọrụ nhazi ahaziri iche ka ọ dabara mkpa nyocha gị nke ọma.
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3-Methyl-6-Nitroindazole (CAS: 6494-19-5) na-eji dị ka Pharmaceutical Intermediate.Enwere ike iji ya dị ka etiti Pazopanib Hydrochloride (CAS: 635702-64-6).Pazopanib Hydrochloride bụ onye GlaxoSmithKline mere nyocha wee mepụta ya, ọ bụ onye na-egbochi ọgbọ vaskụla ọnụ nke nwere ike igbochi ịlanarị etuto ahụ siri ike yana ọgbọ arịa ọbara ọhụrụ achọrọ.Ezubere ichekwa vaskụla endothelial growth factor receptor (VEGFR), ọ na-arụ ọrụ site na igbochi angiogenesis nke ọkọnọ ọbara etuto.Ọ dabara maka carcinoma cell renal dị elu (nchọpụta nke mkpụrụ ndụ kansa na tubules renal), sarcoma anụ ahụ dị nro (STS), ọrịa cancer ovary epithelial na ọgwụgwọ ọrịa cancer akpa ume na-abụghị obere cell (NSCLC).Nchịkwa nri na ọgwụ ọjọọ nke US (FDA) kwadoro na Ọktoba 19, 2009 na edepụtara Pazopanib Hydrochloride ( aha ahia Votrient ) , ọgwụgwọ ọgwụ nke isii akwadoro maka ọrịa kansa akụrụ kemgbe 2005.